1,029 research outputs found
Porting Decision Tree Algorithms to Multicore using FastFlow
The whole computer hardware industry embraced multicores. For these machines,
the extreme optimisation of sequential algorithms is no longer sufficient to
squeeze the real machine power, which can be only exploited via thread-level
parallelism. Decision tree algorithms exhibit natural concurrency that makes
them suitable to be parallelised. This paper presents an approach for
easy-yet-efficient porting of an implementation of the C4.5 algorithm on
multicores. The parallel porting requires minimal changes to the original
sequential code, and it is able to exploit up to 7X speedup on an Intel
dual-quad core machine.Comment: 18 pages + cove
Scaling limit of virtual states of triatomic systems
For a system with three identical atoms, the dependence of the wave
virtual state energy on the weakly bound dimer and trimer binding energies is
calculated in a form of a universal scaling function. The scaling function is
obtained from a renormalizable three-body model with a pairwise Dirac-delta
interaction. It was also discussed the threshold condition for the appearance
of the trimer virtual state.Comment: 9 pages, 3 figure
Follow-up plasma apolipoprotein E levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) cohort
Introduction: Alzheimer's disease (AD) is a growing socioeconomic problem worldwide. Early diagnosis and prevention of this devastating disease have become a research priority. Consequently, the identification of clinically significant and sensitive blood biomarkers for its early detection is very important. Apolipoprotein E (APOE) is a well-known and established genetic risk factor for late-onset AD; however, the impact of the protein level on AD risk is unclear. We assessed the utility of plasma ApoE protein as a potential biomarker of AD in the large, well-characterised Australian Imaging, Biomarkers and Lifestyle Study of Ageing (AIBL) cohort.
Methods: Total plasma ApoE levels were measured at 18-month follow-up using a commercial bead-based enzyme-linked immunosorbent assay: the Luminex xMAP human apolipoprotein kit. ApoE levels were then analysed between clinical classifications (healthy controls, mild cognitive impairment (MCI) and AD) and correlated with the data available from the AIBL cohort, including but not limited to APOE genotype and cerebral amyloid burden.
Results: A significant decrease in ApoE levels was found in the AD group compared with the healthy controls. These results validate previously published ApoE protein levels at baseline obtained using different methodology. ApoE protein levels were also significantly affected, depending on APOE genotypes, with ε2/ε2 having the highest protein levels and ε4/ε4 having the lowest. Plasma ApoE levels were significantly negatively correlated with cerebral amyloid burden as measured by neuroimaging.
Conclusions: ApoE is decreased in individuals with AD compared with healthy controls at 18-month follow-up, and this trend is consistent with our results published at baseline. The influence of APOE genotype and sex on the protein levels are also explored. It is clear that ApoE is a strong player in the aetiology of this disease at both the protein and genetic levels
Transcriptomic analyses reveal differential gene expression of immune and cell death pathways in the brains of mice infected with West Nile virus and chikungunya virus
West Nile virus (WNV) and chikungunya virus (CHIKV) are arboviruses that are constantly (re-)emerging and expanding their territory. Both viruses often cause a mild form of disease, but severe forms of the disease can consist of neurological symptoms, most often observed in the elderly and young children, respectively, for which the mechanisms are poorly understood. To further elucidate the mechanisms responsible for end-stage WNV and CHIKV neuroinvasive disease, we used transcriptomics to compare the induction of effector pathways in the brain during the early and late stage of disease in young mice. In addition to the more commonly described cell death pathways such as apoptosis and autophagy, we also found evidence for the differential expression of pyroptosis and necroptosis cell death markers during both WNV and CHIKV neuroinvasive disease. In contrast, no evidence of cell dysfunction was observed, indicating that cell death may be the most important mechanism of disease. Interestingly, there was overlap when comparing immune markers involved in neuroinvasive disease to those seen in neurodegenerative diseases. Nonetheless, further validation studies are needed to determine the activation and involvement of these effector pathways at the end stage of disease. Furthermore, evidence for a strong inflammatory response was found in mice infected with WNV and CHIKV. The transcriptomics profile measured in mice with WNV and CHIKV neuroinvasive disease in our study showed strong overlap with the mRNA profile described in the literature for other viral neuroinvasive diseases. More studies are warranted to decipher the role of cell inflammation and cell death in viral neuroinvasive disease and whether common mechanisms are active in both neurodegenerative and brain infectious diseases
A prospective comparison of UK and Malaysian patients with irritable bowel syndrome in secondary care
Background
The prevalence of irritable bowel syndrome (IBS) is now known to be similar in various geographical regions, but there has been no study directly comparing characteristics of patients with IBS between populations.
Aims
To evaluate clinical and psychological differences between adults with IBS seen in secondary care in the United Kingdom (UK) and Malaysia.
Methods
Age- and sex-matched patients with IBS from a single centre in the UK (Leeds) and two centres in Malaysia (Kuala Lumpur and Kota Bharu), who fulfilled Rome III criteria, were recruited prospectively. Demographic characteristics and gastrointestinal and psychological symptoms were compared between both groups.
Results
A total of 266 (133 UK and 133 Malaysian) age- and sex-matched patients with Rome III IBS were recruited (mean age: 45.1 years Malaysia, vs. 46.5 years UK; 57.9% female). UK patients were more likely to consume alcohol than Malaysian patients (54.1% vs. 10.5%, p < 0.001). Compared with Malaysian patients, UK patients had more frequent abdominal pain, abdominal bloating, meal-related symptoms (p < 0.001 for all), higher symptom scores (mean 268.0 vs 166.0; p < 0.001), greater limitation of activities due to IBS (p = 0.007) and were more likely to report abnormal anxiety scores (p < 0.001). Higher perceived stress (mean 21.3 vs. 19.1, p = 0.014) and gastrointestinal symptom-specific anxiety scores (mean 50.8 vs. 43.0, p < 0.001) were also observed in UK patients. Finally, UK patients had higher somatoform symptom-reporting scores (mean 8.9 vs. 6.9, p < 0.001).
Conclusions
IBS is more severe and is associated with a higher level of psychological symptoms in the UK compared with Malaysian patients in secondary care
Universality in the Three-Body Problem for 4He Atoms
The two-body scattering length a for 4He atoms is much larger than their
effective range r_s. As a consequence, low-energy few-body observables have
universal characteristics that are independent of the interaction potential.
Universality implies that, up to corrections suppressed by r_s/a, all
low-energy three-body observables are determined by a and a three-body
parameter \Lambda_*. We give simple expressions in terms of a and \Lambda_* for
the trimer binding energy equation, the atom-dimer scattering phase shifts, and
the rate for three-body recombination at threshold. We determine \Lambda_* for
several 4He potentials from the calculated binding energy of the excited state
of the trimer and use it to obtain the universality predictions for the other
low-energy observables. We also use the calculated values for one potential to
estimate the effective range corrections for the other potentials.Comment: 23 pages, revtex4, 6 ps figures, references added, universal
expressions update
The ^4He trimer as an Efimov system
We review the results obtained in the last four decades which demonstrate the
Efimov nature of the He three-atomic system.Comment: Review article for a special issue of the Few-Body Systems journal
devoted to Efimov physic
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