A quasi-static nonlinear analysis for assessing the fire resistance of 3d frames exploiting time-dependent yield surface

In this work an automatic procedure for evaluating the axial force-biaxial bending yield surface of reinforced concrete sections in fire is proposed. It provides an accurate time-dependent expression of the yield condition by a section analysis carried out once and for all, accounting for the strength reduction of the materials, which is a function of the fire duration. The equilibrium state of 3D frames with such yield conditions, once discretized using beam finite elements, is formulated as a nonlinear vectorial equation defining a curve in the hyperspace of the discrete variables and the fire duration. A generalized path-following strategy is proposed for tracing this curve and evaluating, if it exists, the limit fire duration, that is the time of exposure which leads to structural collapse. Compared to the previous proposals on the topic, which are limited to local sectional checks, this work is the first to present a global analysis for assessing the fire resistance of 3D frames, providing a time history of the fire event and taking account of the stress redistribution. Numerical examples are given to illustrate and validate the proposal

Quality of life in patients with moderate to severe ulcerative colitis and the impact of treatment: A narrative review.

As a chronic inflammatory disease, ulcerative colitis has significant negative impact on the quality of life (QoL) of patients. Since the disease affects many aspects of QoL, comprising multiple domains, treatments that induce and maintain remission can provide benefits beyond hard clinical endpoints. Effective treatment of ulcerative colitis can restore QoL and return it to normal or near normal levels. Biological therapies have shown consistent improvement in the QoL of patients with ulcerative colitis during the induction phase, with benefits that are generally maintained in the long-term. Current medical treatment options broadly comprise aminosalicylates, corticosteroids, thiopurines, and calcineurin inhibitors, as well as biologic therapies. Conventional therapies do not always adequately control disease in a sizeable portion of patients, while anti-TNF antibodies are associated with several issues such as contraindications, intolerance, primary non-response, and loss of response in some patients. JAK inhibitors have been associated with clinical improvements in disease manifestations and long-term improvement in QoL outcomes. However, additional studies are needed to better understand the comparative effects of different treatments on QoL and patient preferences for therapy. Herein, the available evidence is reviewed regarding the impact of various treatments on QoL in patients with moderate to severe ulcerative colitis

Separating the North and South Pacific Meridional Modes Contributions to ENSO and Tropical Decadal Variability

North and South Pacific Meridional Modes (NPMM and SPMM) are known precursors of El Niño–Southern Oscillation (ENSO) and Tropical Pacific decadal variability (TPDV). However, the relative importance of these precursors and the timescale on which they impact the tropics remain unclear. Using a 30-member ensemble of the Community Earth System Model as the control climate, we generate two additional members where the NPMM and SPMM are selectively suppressed. We find that both meridional modes energize the tropical variance independently on different timescales. The absence of NPMM leads to a significant reduction of the tropical interannual variability (~35%), while the absence of the SPMM has no appreciable impact on ENSO but significantly reduces the TPDV (~30%). While the relative importance of the NPMM and SPMM may be model dependent, the stochastic atmospheric variability in the extratropics that energizes the meridional modes emerges as a key source of TPDV

Are health literacy and lifestyle of undergraduates related to the educational field? An italian survey

Background: Health literacy (HL) is a fundamental ability to successfully deal with health and illness issues. This study aimed to assess HL among undergraduates from healthcare and non-healthcare degree courses of two Italian universities and the association between their HL, lifestyles, and BMI assumed as health outcome. Methods: The Health Literacy Assessment Tool (HLAT-8) and the Newest Vital Sign (NVS) were used to assess health literacy dimensions. Demographic and anthropometric data, adherence to Mediterranean diet (MD), physical activity levels, and smoking habits were assessed in the enrolled sample to highlight possible associations. Results: A total sample of 806 undergraduates (46% males, mean age 21.01 ± 1.78 years) was recruited. Higher HL scores were found among healthcare rather than non-healthcare students (28.7 ± 4.5 vs. 26.7 ± 4.2 for HLAT-8 and 4.9 ± 1.5 vs. 3.9 ± 1.8 for NVS, p < 0.01). However, healthcare undergraduates were more likely to report unhealthy behaviors. Body Mass Index (BMI) was associated with literacy and numeracy skills only in non-healthcare undergraduates. Significant associations were found between HL scores and adherence to MD in both groups. In the regression analysis, educational field and MD were shown to be predictors of HL scores. Conclusions: Attending a healthcare related degree course was associated with higher HL scores but not with healthy behaviors. This issue should be addressed considering the role that healthcare professionals may have in educating patients towards a healthy lifestyle. Adherence to MD seems to be related to higher HL scores

Non Gaussian extrema counts for CMB maps

In the context of the geometrical analysis of weakly non Gaussian CMB maps, the 2D differential extrema counts as functions of the excursion set threshold is derived from the full moments expansion of the joint probability distribution of an isotropic random field, its gradient and invariants of the Hessian. Analytic expressions for these counts are given to second order in the non Gaussian correction, while a Monte Carlo method to compute them to arbitrary order is presented. Matching count statistics to these estimators is illustrated on fiducial non-Gaussian "Planck" data.Comment: 4 pages, 1 figur

Vaccinations in patients with inflammatory bowel disease.

Treatment of inflammatory bowel disease (IBD) frequently requires administration of immunosuppressive therapies, which increases susceptibility to a number of infectious pathogens. However, many infections can be prevented by correct and appropriate utilization of vaccinations. While several guidelines have been published on vaccination schedules in patients with IBD, vaccination rates remain suboptimal and even lower than those in the general population. This is due to many factors including poor awareness of the importance of vaccines by gastroenterologists and general practitioners as well as potential prejudices of patients regarding the safety and benefits of vaccines. With the aim of increasing awareness about the key role of immunization in the management of patients with IBD, the present review examines the existing literature relating to the main vaccinations and their application in these patients. We also summarize current evidence in order to provide clinicians with an easy source of reference for the principal recommendations for prevention of infectious diseases in patients with IBD. In addition, the recommendations about traveling for IBD patients are briefly explored. Lastly, since it is important for gastroenterologists to be aware of recommendations on vaccination, we recommend implementing educational programs to ensure compliance with current guidelines

Observational constraints on patch inflation in noncommutative spacetime

We study constraints on a number of patch inflationary models in noncommutative spacetime using a compilation of recent high-precision observational data. In particular, the four-dimensional General Relativistic (GR) case, the Randall-Sundrum (RS) and Gauss-Bonnet (GB) braneworld scenarios are investigated by extending previous commutative analyses to the infrared limit of a maximally symmetric realization of the stringy uncertainty principle. The effect of spacetime noncommutativity modifies the standard consistency relation between the tensor spectral index and the tensor-to-scalar ratio. We perform likelihood analyses in terms of inflationary observables using new consistency relations and confront them with large-field inflationary models with potential V \propto \vp^p in two classes of noncommutative scenarios. We find a number of interesting results: (i) the quartic potential (p=4) is rescued from marginal rejection in the class 2 GR case, and (ii) steep inflation driven by an exponential potential (p \to \infty) is allowed in the class 1 RS case. Spacetime noncommutativity can lead to blue-tilted scalar and tensor spectra even for monomial potentials, thus opening up a possibility to explain the loss of power observed in the cosmic microwave background anisotropies. We also explore patch inflation with a Dirac-Born-Infeld tachyon field and explicitly show that the associated likelihood analysis is equivalent to the one in the ordinary scalar field case by using horizon-flow parameters. It turns out that tachyon inflation is compatible with observations in all patch cosmologies even for large p.Comment: 16 pages, 11 figures; v2: updated references, minor corrections to match the Phys. Rev. D versio