End-to-End Learning in Optical Fiber Communications: Experimental Demonstration and Future Trends

Fiber-optic auto-encoders are demonstrated on an intensity modulation/direct detection testbed, outperforming state-of-the-art signal processing. Algorithms for end-to-end optimization using experimentally collected data are discussed. The end-to-end learning framework is extended for performing optimization of the symbol distribution in probabilistically-shaped coherent systems

When should cardiovascular prevention begin? The importance of antenatal, perinatal and primordial prevention

Cardiovascular diseases represent a major health problem, being one of the leading causes of morbidity and mortality worldwide. Therefore, in this scenario, cardiovascular prevention plays an essential role although it is difficult to establish when promoting and implementing preventive strategies. However, there is growing evidence that prevention should start even before birth, during pregnancy, aiming to avoid the onset of cardiovascular risk factors, since events that occur early in life have a great impact on the cardiovascular risk profile of an adult. The two pillars of this early preventive strategy are nutrition and physical exercise, together with prevention of cardio-metabolic diseases during pregnancy. This review attempts to gather the growing evidence of the benefits of antenatal, perinatal and primordial prevention, discussing also the possibility to reverse or to mitigate the cardiovascular profile developed in the initial stages of life. This could pave the way for future research, investigating the optimal time and duration of these preventing measures, their duration and maintenance in adulthood, and the most effective interventions according to the different age and guiding in the next years, the best clinical practice and the political strategies to cope with cardiovascular disease

Enhanced superchannel transmission using phase conjugation

We demonstrate polarisation insensitive dual-band optical phase conjugation for multiple 400Gbit/s optical superchannels using a Raman amplified transmission link with a realistic span length of 75km. The resultant increase in transmission distance is confirmed analytically

MEDICAL AND SOCIAL CHARACTERISTICS OF WOMEN OF YOUNG REPRODUCTIVE AGE AFTER HYSTERECTOMY

Background. In many countries, hysterectomy is one of the most frequently performed surgical procedures.The objective of our analysis was to assess the social and medical characteristics of young reproductive-age patients who underwent hysterectomy.Materials and methods. A retrospective study involved 140 women aged 18–35 years (median age 29.4 ± 4.7 years) who underwent emergency or elective hysterectomy in the hospitals of Zabaykalsky Krai for a period of 5 years (January 1, 2013, to December 31, 2017).Results. 51.4 % of patients were housewives; 52.9 % were single; 55.7 % had bad habits (smoking, alcohol consumption). These women had a high incidence of socially significant infections: HIV – 3.6 %, active forms of tuberculosis – 1.5 %. 89.3 % of hysterectomies were emergent and 10.7 % were elective (p = 0.0001; OR = 69.4; 95% CI 32.6–148.1). The indications for the emergency hysterectomy were uterine myoma (80 %) and cervical or ovarian cancer (20 %). The obstetrical complications were the main indications for the emergency surgery: placenta abruption – 24.0 %; placenta previa – 20.8 % (placenta increta and/or percreta – 16.8 %; massive antenatal bleeding – 4.0 %); postpartum hemorrhage after vaginal delivery and caesarean section 19.2 %; septic and/or hemorrhagic shock in early miscarriages (from 8 to 19 weeks of gestation) 15.2 %. Mortality was registered in case of emergency hysterectomy only (4.3 %). Half of the deaths (50 %) occurred in cases of complicated miscarriages.Conclusion. To preserve the reproductive potential of young women of reproductive age, it is necessary to increase their social and cultural level, and responsibility for their own health and gender behavior

Using the past to constrain the future: how the palaeorecord can improve estimates of global warming

Climate sensitivity is defined as the change in global mean equilibrium temperature after a doubling of atmospheric CO2 concentration and provides a simple measure of global warming. An early estimate of climate sensitivity, 1.5-4.5{\deg}C, has changed little subsequently, including the latest assessment by the Intergovernmental Panel on Climate Change. The persistence of such large uncertainties in this simple measure casts doubt on our understanding of the mechanisms of climate change and our ability to predict the response of the climate system to future perturbations. This has motivated continued attempts to constrain the range with climate data, alone or in conjunction with models. The majority of studies use data from the instrumental period (post-1850) but recent work has made use of information about the large climate changes experienced in the geological past. In this review, we first outline approaches that estimate climate sensitivity using instrumental climate observations and then summarise attempts to use the record of climate change on geological timescales. We examine the limitations of these studies and suggest ways in which the power of the palaeoclimate record could be better used to reduce uncertainties in our predictions of climate sensitivity.Comment: The final, definitive version of this paper has been published in Progress in Physical Geography, 31(5), 2007 by SAGE Publications Ltd, All rights reserved. \c{opyright} 2007 Edwards, Crucifix and Harriso

Disease awareness campaigns in printed and online media in Latvia : Cross-sectional study on consistency with WHO ethical criteria for medicinal drug promotion and European standards

Funding Information: Teresa Leonardo Alves declares no conflicts of interest. She has worked in the past for not-for-profit organizations which have advocated against the relaxation of the direct-to-consumer advertising ban in the European Union, namely Prescrire (2012–2016) and Health Action International (2006–2011). Elita Poplavska is a board member of not-for-profit organizations - Health Projects for Latvia and Health Action International (which aim to promote rational use of medicines and reduce influence of pharmaceutical advertisement). Signe Mezinska is a board member of not-for-profit organizations - Health Projects for Latvia and Health Action International (which aim to promote rational use of medicines and reduce influence of pharmaceutical advertisement). Ieva Salmane-Kulikovska declares no conflicts of interest. Liga Andersone declares no conflicts of interest. Aukje Mantel-Teeuwisse is the Managing Director of the WHO Collaborating Centre for Pharmaceutical Policy & Regulation, which receives no direct funding or donations from private parties, including the pharmaceutical industry. Research funding from public-private partnerships, e.g. IMI, Lygature (https://www.lygature.org), is accepted under the condition that no company-specific product or company-related study is conducted. The Centre has received unrestricted research funding from public sources, e.g. Netherlands Organisation for Health Research and Development (ZonMW), Zorg Instituut Nederland (ZIN), the Dutch Medicines Evaluation Board (MEB), and the Dutch Ministry of Health. Barbara Mintzes has acted as an expert witness on behalf of plaintiffs in a Canadian class action suit on cardiovascular risks of testosterone therapy. Publisher Copyright: © 2018 The Author(s).Background: European legislation prohibits direct-to-consumer advertising of prescription medicines, but allows drug manufacturers to provide information to the public on health and diseases. Our aim was to measure the frequency of disease awareness campaigns in Latvian media and assess their compliance with international and European standards. Methods: Materials on health/disease and treatments were collected between April and September 2015 from 12 newspapers and magazines and six online portals. Disease awareness campaigns were assessed using a previously developed instrument based on the WHO Ethical Criteria for Medicinal Drug promotion and European standards (EU law and pharmaceutical industry self-regulatory guidelines). Collected materials were used to examine the information provided on medical conditions and their diagnosis and treatment. The inter-rater reliability was calculated. Results: We collected 263 materials from print (n = 149) and online media (n = 114); 94 were news items and 169 were disease-awareness advertisements. Cancer, cardiovascular problems, allergies and respiratory diseases were common topics. Of the 157 campaigns assessed, non-compliance was identified in 149 cases (inter-rater reliability 90%), mainly due to misleading or incomplete information, lack of balance and the absence of a listed author/sponsor. Six disease awareness campaigns directly mentioned a pharmaceutical product by brand name and other four included the logo or name of a manufacturer, referred to a condition and indirectly mentioned a treatment, all in contravention with European law. Conclusions: The compliance of disease awareness campaigns in Latvian media with international and European standards is low. This raises concerns about the nature of information being conveyed. Through lack of balance, missing sponsorship information, and misleading or incomplete information, these campaigns could contribute to inaccurate self-diagnosis and generate demand among those who might not need medical treatment.publishersversionPeer reviewe

4 Tb/s Transmission Reach Enhancement Using 10 x 400 Gb/s Super-Channels and Polarization Insensitive Dual Band Optical Phase Conjugation

In this paper, we experimentally demonstrate the benefit of polarization insensitive dual-band optical phase conjugation for up to ten 400 Gb/s optical super-channels using a Raman amplified transmission link with a realistic span length of 75 km. We demonstrate that the resultant increase in transmission distance may be predicted analytically if the detrimental impacts of power asymmetry and polarization mode dispersion are taken into account

Calcified Algae for Tissue Engineering.

This book presents the latest advances in marine structures and related biomaterials for applications in both soft- and hard-tissue engineering, as well as controlled drug delivery

Comparison of the structure of the plasma-facing surface and tritium accumulation in beryllium tiles from JET ILW campaigns 2011-2012 and 2013-2014

In this study, beryllium tiles from Joint European Torus (JET) vacuum vessel wall were analysed and compared regarding their position in the vacuum vessel and differences in the exploitation conditions during two campaigns of ITER-Like-Wall (ILW) in 2011–2012 (ILW1) and 2013–2014 (ILW2) Tritium content in beryllium samples were assessed. Two methods were used to measure tritium content in the samples – dissolution under controlled conditions and tritium thermal desorption. Prior to desorption and dissolution experiments, scanning electron microscopy and energy dispersive x-ray spectroscopy were used to study structure and chemical composition of plasma-facing-surfaces of the beryllium samples. Experimental results revealed that tritium content in the samples is in range of 2·10$^{11}$–2·10$^{13}$ tritium atoms per square centimetre of the surface area with its highest content in the samples from the outer wall of the vacuum vessel (up to 1.9·10$^{13}$ atoms/cm$^{2}$ in ILW1 campaign and 2.4·10$^{13}$ atoms/cm$^{2}$ in ILW2). The lowest content of tritium was found in the upper part of the vacuum vessel (2.0·10$^{12}$ atoms/cm$^{2}$ and 2.0·10$^{11}$ atoms/cm$^{2}$ in ILW1 and ILW2, respectively). Results obtained from scanning electron microscopy has shown that surface morphology is different within single tile, however if to compare two campaigns main tendencies remains similar

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery