64 research outputs found
First Passage Time Densities in Non-Markovian Models with Subthreshold Oscillations
Motivated by the dynamics of resonant neurons we consider a differentiable,
non-Markovian random process and particularly the time after which it
will reach a certain level . The probability density of this first passage
time is expressed as infinite series of integrals over joint probability
densities of and its velocity . Approximating higher order terms
of this series through the lower order ones leads to closed expressions in the
cases of vanishing and moderate correlations between subsequent crossings of
. For a linear oscillator driven by white or coloured Gaussian noise,
which models a resonant neuron, we show that these approximations reproduce the
complex structures of the first passage time densities characteristic for the
underdamped dynamics, where Markovian approximations (giving monotonous first
passage time distribution) fail
Ultrafast 3d spin-echo acquisition improves gadolinium-enhanced mri signal contrast enhancement
Long scan times of 3D volumetric MR acquisitions usually necessitate ultrafast in vivo gradient-echo acquisitions, which are intrinsically susceptible to magnetic field inhomogeneities. This is especially problematic for contrast-enhanced (CE)-MRI applications, where non-negligible T 2 & z.ast; effect of contrast agent deteriorates the positive signal contrast and limits the available range of MR acquisition parameters and injection doses. To overcome these shortcomings without degrading temporal resolution, ultrafast spin-echo acquisitions were implemented. Specifically, a multiplicative acceleration factor from multiple spin echoes (??32) and compressed sensing (CS) sampling (??8) allowed highly-accelerated 3D Multiple-Modulation- Multiple-Echo (MMME) acquisition. At the same time, the CE-MRI of kidney with Gd-DOTA showed significantly improved signal enhancement for CS-MMME acquisitions (??7) over that of corresponding FLASH acquisitions (??2). Increased positive contrast enhancement and highly accelerated acquisition of extended volume with reduced RF irradiations will be beneficial for oncological and nephrological applications, in which the accurate in vivo 3D quantification of contrast agent concentration is necessary with high temporal resolution.open0
New Clathrin-Based Nanoplatforms for Magnetic Resonance Imaging
Background: Magnetic Resonance Imaging (MRI) has high spatial resolution, but low sensitivity for visualization of molecular targets in the central nervous system (CNS). Our goal was to develop a new MRI method with the potential for non-invasive molecular brain imaging. We herein introduce new bio-nanotechnology approaches for designing CNS contrast media based on the ubiquitous clathrin cell protein. Methodology/Principal Findings: The first approach utilizes three-legged clathrin triskelia modified to carry 81 gadolinium chelates. The second approach uses clathrin cages self-assembled from triskelia and designed to carry 432 gadolinium chelates. Clathrin triskelia and cages were characterized by size, structure, protein concentration, and chelate and gadolinium contents. Relaxivity was evaluated at 0.47 T. A series of studies were conducted to ascertain whether fluorescent-tagged clathrin nanoplatforms could cross the blood brain barriers (BBB) unaided following intranasal, intravenous, and intraperitoneal routes of administration. Clathrin nanoparticles can be constituted as triskelia (18.5 nm in size), and as cages assembled from them (55 nm). The mean chelate: clathrin heavy chain molar ratio was 27.0464.8: 1 fo
BODY FAT DISTRIBUTION, DYSLIPIDEMIA, BLOOD PRESSURE AND EFFECTS OF SMOKING IN GERMAN VERSUS TURKISH MEN AND WOMEN
All-trans Geranylgeranyl Acetate and Geranylgeraniol, Recruitment Pheromone Components in the Dufour Gland of the Ponerine Ant Ectatomma ruidumPheromones, 100 [1]
Response to “Right Analysis—Wrong Conclusion: Obese Youth With Higher BP Are at Risk for Target Organ Damage”
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