Prospectus, April 30, 1997

https://spark.parkland.edu/prospectus_1997/1014/thumbnail.jp

Prospectus, December 8, 1993

https://spark.parkland.edu/prospectus_1993/1019/thumbnail.jp

Prospectus, October 13, 1993

https://spark.parkland.edu/prospectus_1993/1015/thumbnail.jp

Prospectus, November 10, 1993

https://spark.parkland.edu/prospectus_1993/1017/thumbnail.jp

Prospectus, September 29, 1993

https://spark.parkland.edu/prospectus_1993/1014/thumbnail.jp

Comparative effectiveness of drugs used to constrict the patent ductus arteriosus: a secondary analysis of the PDA-TOLERATE trial (NCT01958320).

ObjectiveTo evaluate the effectiveness of drugs used to constrict patent ductus arteriosus (PDA) in newborns < 28 weeks.MethodsWe performed a secondary analysis of the multi-center PDA-TOLERATE trial (NCT01958320). Infants with moderate-to-large PDAs were randomized 1:1 at 8.1 ± 2.1 days to either Drug treatment (n = 104) or Conservative management (n = 98). Drug treatments were assigned by center rather than within center (acetaminophen: 5 centers, 27 infants; ibuprofen: 7 centers, 38 infants; indomethacin: 7 centers, 39 infants).ResultsIndomethacin produced the greatest constriction (compared with spontaneous constriction during Conservative management): RR (95% CI) = 3.21 (2.05-5.01)), followed by ibuprofen = 2.03 (1.05-3.91), and acetaminophen = 1.33 (0.55-3.24). The initial rate of acetaminophen-induced constriction was 27%. Infants with persistent moderate-to-large PDA after acetaminophen were treated with indomethacin. The final rate of constriction after acetaminophen ± indomethacin was 60% (similar to the rate in infants receiving indomethacin-alone (62%)).ConclusionIndomethacin was more effective than acetaminophen in producing ductus constriction

Prospectus, December 9, 1991

https://spark.parkland.edu/prospectus_1991/1018/thumbnail.jp