40 research outputs found
Enabling the Development and Deployment of Next Generation Point-of-Care Diagnostics
<p>Enabling the Development and Deployment of Next Generation Point-of-Care Diagnostics</p
Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression
Over the past decade, it has become clear that mammalian genomes encode thousands of long non-coding RNAs (lncRNAs), many of which are now implicated in diverse biological processes. Recent work studying the molecular mechanisms of several key examples — including Xist, which orchestrates X chromosome inactivation — has provided new insights into how lncRNAs can control cellular functions by acting in the nucleus. Here we discuss emerging mechanistic insights into how lncRNAs can regulate gene expression by coordinating regulatory proteins, localizing to target loci and shaping three-dimensional (3D) nuclear organization. We explore these principles to highlight biological challenges in gene regulation, in which lncRNAs are well-suited to perform roles that cannot be carried out by DNA elements or protein regulators alone, such as acting as spatial amplifiers of regulatory signals in the nucleus
Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression
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Identification and Management of Cardiometabolic Risk after Spinal Cord Injury
Comparison of coronary artery calcification scores and National Cholesterol Education Program guidelines for coronary heart disease risk assessment and treatment paradigms in individuals with chronic traumatic spinal cord injury
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Identification and Management of Cardiometabolic Risk after Spinal Cord Injury: Clinical Practice Guideline for Health Care Providers
Supernova triggers for end:Devonian extinctions
The Late Devonian was a protracted period of low speciation resulting in
biodiversity decline, culminating in extinction events near the
Devonian-Carboniferous boundary. Recent evidence indicates that the final
extinction event may have coincided with a dramatic drop in stratospheric
ozone, possibly due to a global temperature rise. Here we study an alternative
possible cause for the postulated ozone drop: a nearby supernova explosion that
could inflict damage by accelerating cosmic rays that can deliver ionizing
radiation for up to kyr. We therefore propose that the end-Devonian
extinctions were triggered by supernova explosions at pc, somewhat
beyond the "kill distance" that would have precipitated a full mass extinction.
Such nearby supernovae are likely due to core-collapses of massive stars; these
are concentrated in the thin Galactic disk where the Sun resides. Detecting
either of the long-lived radioisotopes Sm-146 or Pu-244 in one or more
end-Devonian extinction strata would confirm a supernova origin, point to the
core-collapse explosion of a massive star, and probe supernova nucleosythesis.
Other possible tests of the supernova hypothesis are discussed.Comment: 3 pages, no figures. Matches published version. Creative Commons CC
BY-NC-ND licens