157 research outputs found
Classical and quantum decay of one dimensional finite wells with oscillating walls
To study the time decay laws (tdl) of quasibounded hamiltonian systems we
have considered two finite potential wells with oscillating walls filled by non
interacting particles. We show that the tdl can be qualitatively different for
different movement of the oscillating wall at classical level according to the
characteristic of trapped periodic orbits. However, the quantum dynamics do not
show such differences.Comment: RevTeX, 15 pages, 14 PostScript figures, submitted to Phys. Rev.
Chaotic dynamics of cold atoms in far-off-resonant donut beam
We describe the classical two dimensinal nonlinear dynamics of cold atoms in
far-off-resonant donut beams. We show that there chaotic dynamics exists for
charge greater than unity, when the intensity of the beam is periodically
modulated. The two dimensional distributions of atoms in plane for
charge two are simulated. We show that the atoms will acumulate on several ring
regions when the system enters to regime of global chaos.Comment: 8 pages, 8 figure
A mechanical model of normal and anomalous diffusion
The overdamped dynamics of a charged particle driven by an uniform electric
field through a random sequence of scatterers in one dimension is investigated.
Analytic expressions of the mean velocity and of the velocity power spectrum
are presented. These show that above a threshold value of the field normal
diffusion is superimposed to ballistic motion. The diffusion constant can be
given explicitly. At the threshold field the transition between conduction and
localization is accompanied by an anomalous diffusion. Our results exemplify
that, even in the absence of time-dependent stochastic forces, a purely
mechanical model equipped with a quenched disorder can exhibit normal as well
as anomalous diffusion, the latter emerging as a critical property.Comment: 16 pages, no figure
Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways
Background
Recent advances in single-cell techniques have provided the opportunity to finely dissect cellular heterogeneity within populations previously defined by “bulk” assays and to uncover rare cell types. In human hematopoiesis, megakaryocytes and erythroid cells differentiate from a shared precursor, the megakaryocyte-erythroid progenitor (MEP), which remains poorly defined.
Results
To clarify the cellular pathway in erythro-megakaryocyte differentiation, we correlate the surface immunophenotype, transcriptional profile, and differentiation potential of individual MEP cells. Highly purified, single MEP cells were analyzed using index fluorescence-activated cell sorting and parallel targeted transcriptional profiling of the same cells was performed using a specifically designed panel of genes. Differentiation potential was tested in novel, single-cell differentiation assays. Our results demonstrate that immunophenotypic MEP comprise three distinct subpopulations: “Pre-MEP,” enriched for erythroid/megakaryocyte progenitors but with residual myeloid differentiation capacity; “E-MEP,” strongly biased towards erythroid differentiation; and “MK-MEP,” a previously undescribed, rare population of cells that are bipotent but primarily generate megakaryocytic progeny. Therefore, conventionally defined MEP are a mixed population, as a minority give rise to mixed-lineage colonies while the majority of cells are transcriptionally primed to generate exclusively single-lineage output.
Conclusions
Our study clarifies the cellular hierarchy in human megakaryocyte/erythroid lineage commitment and highlights the importance of using a combination of single-cell approaches to dissect cellular heterogeneity and identify rare cell types within a population. We present a novel immunophenotyping strategy that enables the prospective identification of specific intermediate progenitor populations in erythro-megakaryopoiesis, allowing for in-depth study of disorders including inherited cytopenias, myeloproliferative disorders, and erythromegakaryocytic leukemias
Strong and weak chaos in weakly nonintegrable many-body Hamiltonian systems
We study properties of chaos in generic one-dimensional nonlinear Hamiltonian
lattices comprised of weakly coupled nonlinear oscillators, by numerical
simulations of continuous-time systems and symplectic maps. For small coupling,
the measure of chaos is found to be proportional to the coupling strength and
lattice length, with the typical maximal Lyapunov exponent being proportional
to the square root of coupling. This strong chaos appears as a result of
triplet resonances between nearby modes. In addition to strong chaos we observe
a weakly chaotic component having much smaller Lyapunov exponent, the measure
of which drops approximately as a square of the coupling strength down to
smallest couplings we were able to reach. We argue that this weak chaos is
linked to the regime of fast Arnold diffusion discussed by Chirikov and
Vecheslavov. In disordered lattices of large size we find a subdiffusive
spreading of initially localized wave packets over larger and larger number of
modes. The relations between the exponent of this spreading and the exponent in
the dependence of the fast Arnold diffusion on coupling strength are analyzed.
We also trace parallels between the slow spreading of chaos and deterministic
rheology.Comment: 15 pages, 14 figure
Linear Field Dependence of the Normal-State In-Plane Magnetoresistance of Sr2RuO4
The transverse and longitudinal in-plane magnetoresistances in the normal
state of superconducting Sr2RuO4 single crystals have been measured. At low
temperatures, both of them were found to be positive with a linear
magnetic-field dependence above a threshold field, a result not expected from
electronic band theory. We argue that such behavior is a manifestation of a
novel coherent state characterized by a spin pseudo gap in the quasi-particle
excitation spectrum in Sr2RuO4.Comment: 4 pages + 5 figure
Characteristics of Quantum-Classical Correspondence for Two Interacting Spins
The conditions of quantum-classical correspondence for a system of two
interacting spins are investigated. Differences between quantum expectation
values and classical Liouville averages are examined for both regular and
chaotic dynamics well beyond the short-time regime of narrow states. We find
that quantum-classical differences initially grow exponentially with a
characteristic exponent consistently larger than the largest Lyapunov exponent.
We provide numerical evidence that the time of the break between the quantum
and classical predictions scales as log(), where is
a characteristic system action. However, this log break-time rule applies only
while the quantum-classical deviations are smaller than order hbar. We find
that the quantum observables remain well approximated by classical Liouville
averages over long times even for the chaotic motions of a few
degree-of-freedom system. To obtain this correspondence it is not necessary to
introduce the decoherence effects of a many degree-of-freedom environment.Comment: New introduction, accepted in Phys Rev A (May 2001 issue), 12 latex
figures, 3 ps figure
Nonintegrable Interaction of Ion-Acoustic and Electromagnetic Waves in a Plasma
In this paper we re-examine the one-dimensional interaction of
electromagnetic and ion acoustic waves in a plasma. Our model is similar to one
solved by Rao et al. (Phys. Fluids, vol. 26, 2488 (1983)) under a number of
analytical approximations. Here we perform a numerical investigation to examine
the stability of the model. We find that for slightly over dense plasmas, the
propagation of stable solitary modes can occur in an adiabatic regime where the
ion acoustic electric field potential is enslaved to the electromagnetic field
of a laser. But if the laser intensity or plasma density increases or the laser
frequency decreases, the adiabatic regime loses stability via a transition to
chaos. New asymptotic states are attained when the adiabatic regime no longer
exists. In these new states, the plasma becomes rarefied, and the laser field
tends to behave like a vacuum field.Comment: 19 pages, REVTeX, 6 ps figures, accepted for publication in Phys.
Rev.
Multiple Transitions to Chaos in a Damped Parametrically Forced Pendulum
We study bifurcations associated with stability of the lowest stationary
point (SP) of a damped parametrically forced pendulum by varying
(the natural frequency of the pendulum) and (the amplitude of the external
driving force). As is increased, the SP will restabilize after its
instability, destabilize again, and so {\it ad infinitum} for any given
. Its destabilizations (restabilizations) occur via alternating
supercritical (subcritical) period-doubling bifurcations (PDB's) and pitchfork
bifurcations, except the first destabilization at which a supercritical or
subcritical bifurcation takes place depending on the value of . For
each case of the supercritical destabilizations, an infinite sequence of PDB's
follows and leads to chaos. Consequently, an infinite series of period-doubling
transitions to chaos appears with increasing . The critical behaviors at the
transition points are also discussed.Comment: 20 pages + 7 figures (available upon request), RevTex 3.
Pattern formation and localization in the forced-damped FPU lattice
We study spatial pattern formation and energy localization in the dynamics of
an anharmonic chain with quadratic and quartic intersite potential subject to
an optical, sinusoidally oscillating field and a weak damping. The
zone-boundary mode is stable and locked to the driving field below a critical
forcing that we determine analytically using an approximate model which
describes mode interactions. Above such a forcing, a standing modulated wave
forms for driving frequencies below the band-edge, while a ``multibreather''
state develops at higher frequencies. Of the former, we give an explicit
approximate analytical expression which compares well with numerical data. At
higher forcing space-time chaotic patterns are observed.Comment: submitted to Phys.Rev.
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