The issue of contamination by synthetic resins in radiocarbon dating: the case of a painting by Ambrogio Lorenzetti

Abstract Nowadays, the most common products used in restoration are of synthetic origin. Being these resins obtained from fossil oil, they are devoid of 14C. Therefore, a not complete removal from the sample to be dated can be the cause of a consistent apparent ageing of the dated artworks. A chemical pre-treatment is required in order to clean the samples before the measurements. At INFN-LABEC laboratory in Florence, a new procedure based on the use of an extraction with chloroform as solvent was tested. In this paper, the radiocarbon measurements made on a restored polyptyc by Ambrogio Lorenzetti are presented

Oral Immunotherapy for Food-Allergic Children: A Pro-Con Debate.

The prevalence of food allergy has increased in recent years, especially in children. Allergen avoidance, and drugs in case of an allergic reaction, remains the standard of care in food allergy. Nevertheless, increasing attention has been given to the possibility to treat food allergy, through immunotherapy, particularly oral immunotherapy (OIT). Several OIT protocols and clinical trials have been published. Most of them focus on children allergic to milk, egg, or peanut, although recent studies developed protocols for other foods, such as wheat and different nuts. OIT efficacy in randomized controlled trials is usually evaluated as the possibility for patients to achieve desensitization through the consumption of an increasing amount of a food allergen, while the issue of a possible long-term sustained unresponsiveness has not been completely addressed. Here, we evaluated current pediatric OIT knowledge, focusing on the results of clinical trials and current guidelines. Specifically, we wanted to highlight what is known in terms of OIT efficacy and effectiveness, safety, and impact on quality of life. For each aspect, we reported the pros and the cons, inferable from published literature. In conclusion, even though many protocols, reviews and meta-analysis have been published on this topic, pediatric OIT remains a controversial therapy and no definitive generalized conclusion may be drawn so far. It should be an option provided by specialized teams, when both patients and their families are prone to adhere to the proposed protocol. Efficacy, long-term effectiveness, possible role of adjuvant therapies, risk of severe reactions including anaphylaxis or eosinophilic esophagitis, and impact on the quality of life of both children and caregivers are all aspects that should be discussed before starting OIT. Future studies are needed to provide firm clinical and scientific evidence, which should also consider patient reported outcomes.post-print6382 K

Grociana piccola: a rare example of Republican military fortifications in Italy

Recent investigations at Grociana piccola, a site in northeastern Italy consisting of two sub-rectangular fortifications, offer the rare opportunity to investigate Early Roman military architecture outside the Iberian peninsula. Excavations have revealed an inner rubble masonry rampart dated to the 2nd c. BCE by associated pottery, mainly amphora remains. This date suggests that the fortification was in use during the first Roman conquest and/or later campaigns of the 2nd c. BCE, providing one of the earliest and smallest examples of a military fort. The fort's ramparts were built using the same building technique as much larger 2nd-c. BCE military camps. Another trench uncovered the northeastern corner of the outer rampart and a probable tower or artillery platform which can be connected to a temporary camp built during the mid-1st c. BCE