[Virgen de la Salud] [Material gráfico] / Larrosa g.o

Inscripción: "N.A S.A DE LA SALUD venerada en el lugar de Chiribella "Páez. Repertorio, 1160-

Notes on Hanyu da cidian

The use of composite materials has increased steadily during the past two decades, particularly for aerospace, underwater and automotive structures. This is largely because many composite materials exhibit high strength-to-weight and stifihess-to-weight ratios, which make them ideally suited for use in weight-sensitive structures. The elastic properties of composite materials may be significantly different in specimens manufactured under the same general specifications and the bulk material properties may be different from those of the lamina. The elastic properties degrade as a result of aging, environmental and other effects (e.g., matrix cracking) resulting in overstress and eventual failure of the material. The elastic properties determine the performance of the material and it is necessary to assure the conformance of these properties with design requirements. Conventional destructive techniques for determining the elastic stiffness constants can be costly and often inaccurate. This is particularly true for the through-the-thickness properties. Nondestructive determination of these properties offers a better alternative for material characterization and for assuring structural performance

El que pestañea, pierde : pieza de costumbres andaluzas en verso

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Ghrelin and adiponectin in patients with Cushing's disease before and after successful transsphenoidal surgery

BACKGROUND: Ghrelin, an endogenous ligand of the GH secretagogue receptor that exerts orexigenic activity, is negatively correlated with body mass index (BMI) and insulin resistance. Conversely, low levels of adiponectin (ApN), a circulating adipocytokine with antidiabetic, antiatherogenic and anti-inflammatory properties, have been found in several insulin-resistant conditions. Although Cushing's syndrome causes several metabolic and hormonal changes leading to insulin resistance and central obesity, few data concerning the impact of glucocorticoid excess on ghrelin and ApN levels are so far available. DESIGN: We evaluated ghrelin and ApN levels in 14 women (age +/- SE 39.5 +/- 3.9 years, BMI +/- SE 25.8 +/- 1.4 kg/m2) with Cushing's disease (CD) at baseline and after successful transsphenoidal surgery (TSS) and in 14 age- and BMI-matched healthy women. RESULTS: Despite similar levels of fasting glucose, insulin, homeostatic model assessment-estimated insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI) values, patients with CD had ghrelin levels lower than controls (117.8 +/- 21.5 vs. 269.6 +/- 51.4 pmol/l, P < 0.01), and ghrelin levels did not correlate with ACTH, cortisol, androgen and GH levels. Patients and controls showed similar ApN levels (11.1 +/- 1.6 vs. 11.5 +/- 2.0 mg/l), which correlated negatively with insulin, HOMA-IR and BMI and positively with QUICKI and high density lipoprotein (HDL)-cholesterol only in controls. At 10.2 +/- 0.7 months after successful TSS, patients showed a significant increase in ghrelin levels compared to pretreatment values (342.5 +/- 25.6 vs. 117.8 +/- 21.5 pmol/l, P < 0.005) along with significant modifications in BMI, insulin, HOMA-IR and HDL-cholesterol and no change in ApN levels. In two patients tested on days 2-4 after TSS, no modification in ghrelin and ApN levels was observed, despite a dramatic reduction in cortisol levels. CONCLUSION: Cortisol excess did not directly affect ghrelin and ApN levels in patients with CD. The observation that ghrelin levels were low during the active phase of CD and increased after recovery suggests that glucocorticoids may influence ghrelin levels indirectly by modulating adiposity and metabolic signals over the long term