Novel legacy A-C cable with the capability of predicting abnormal charging

This disclosure describes techniques to monitor the operation of a USB type C connector to prevent damage to charging ports and/or connected devices. The operating temperature of a USB type C connector is monitored by the use of a negative temperature coefficient thermistor (NTC) positioned close to the USB connector. Voltage across the NTC falling below a threshold indicates high temperature and causes the system to disconnect the connector from the power supply. In addition to over temperature protection, if the power supply falls below a threshold, the described system disconnects the connector from the power supply

Fast battery-charging architecture

The disclosure describes a power-efficient, low-footprint, and fast battery charger based on a hybrid of the charge pump and the three-level chargers. The charger is low cost, reduces thermal dissipation, increases battery-charging speed, and is compatible with wired and wireless charging

Statin Decreases Helicobacter pylori Burden in Macrophages by Promoting Autophagy

[[abstract]]Statins, 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors, have been found to provide protective effects against several bacterial infectious diseases. Although the use of statins has been shown to enhance antimicrobial treated Helicobacter pylori eradication and reduce H. pylori-mediated inflammation, the mechanisms underlying these effects remain unclear. In this study, in vitro and ex vivo macrophage models were established to investigate the molecular pathways involved in statin-mediated inhibition of H. pylori-induced inflammation. Our study showed that statin treatment resulted in a dose-dependent decrease in intracellular H. pylori burden in both RAW264.7 macrophage cells and murine peritoneal exudate macrophages (PEMs). Furthermore, statin yielded enhanced early endosome maturation and subsequent activation of the autophagy pathway, which promotes lysosomal fusion resulting in degradation of sequestered bacteria, and in turn attenuates interleukin (IL)-1β production. These results indicate that statin not only reduces cellular cholesterol but also decreases the H. pylori burden in macrophages by promoting autophagy, consequently alleviating H. pylori-induced inflammation