Influence of Different Pretreatments on the Structure and Hydrolysis Behavior of Bamboo: A Comparative Study

Article 2570201

Modified Dachengqi Tang improves decreased gastrointestinal motility in postoperative esophageal cancer patients

AbstractObjectiveTo investigate the clinical effects of modified Dachengqi Tang (DCQT) on promoting gastrointestinal motility in post-operative esophageal cancer patients.MethodsSixty postoperative esophageal cancer patients were enrolled and randomly assigned to the modified treatment group or the control group (30 patients in each group). Patients in the treatment group were given DCQT made from decocted herbs and administered via nasojejunal tube at a dosage of 150 mL. Gastrointestinal motility was assessed by recording time for recovery of bowel sounds, flatus, defecation, and the total amount of gastric drainage during the first three postoperative days. Plasma motilin (MTL) and vasoactive intestinal peptide (VIP) were measured one hour before and three days after surgery.ResultsCompared with the control group, the times to first bowel sound, flatus, and defecation were significantly shorter and there was less gastric drainage in the treatment group (P < 0.01, P < 0.01, P < 0.01, and P < 0.05, respectively). In the treatment group, postoperative plasma MTL was significantly higher (P < 0.01) and VIP was significantly lower than those in the control group (P < 0.05). There was no difference found in either MTL or VIP from before to after operation in the treatment group (P > 0.05). MTL was significantly lower and VIP was higher postoperatively in the control group, compared to before surgery (P < 0.01).ConclusionsModified DCQT effectively improved decreased gastrointestinal motility in postoperative esophageal cancer patients by increasing MTL and reducing VIP

Quantifying the effects of cold waves on carbon monoxide poisoning: A time-stratified case-crossover study in Jinan, China

BackgroundPrevious studies have shown that carbon monoxide (CO) poisoning occurs mostly in winter and is associated with severe cold weather (e.g., ice storms, temperature drops). However, according to previous studies, the impact of low temperature on health has a delayed effect, and the existing research cannot fully reveal the delayed effect of cold waves on CO poisoning.ObjectivesThe purpose of this study is to analyze the temporal distribution of CO poisoning in Jinan and to explore the acute effect of cold waves on CO poisoning.MethodsWe collected emergency call data for CO poisoning in Jinan from 2013 to 2020 and used a time-stratified case-crossover design combined with a conditional logistic regression model to evaluate the impact of the cold wave day and lag 0–8 days on CO poisoning. In addition, 10 definitions of a cold wave were considered to evaluate the impact of different temperature thresholds and durations.ResultsDuring the study period, a total of 1,387 cases of CO poisoning in Jinan used the emergency call system, and more than 85% occurred in cold months. Our findings suggest that cold waves are associated with an increased risk of CO poisoning in Jinan. When P01, P05, and P10 (P01, P05, and P10 refer to the 1st, 5th, and 10th percentiles of the lowest temperature, respectively) were used as temperature thresholds for cold waves, the most significant effects (the maximum OR value, which refers to the risk of CO poisoning on cold wave days compared to other days) were 2.53 (95% CI:1.54, 4.16), 2.06 (95% CI:1.57, 2.7), and 1.49 (95% CI:1.27, 1.74), respectively.ConclusionCold waves are associated with an increased risk of CO poisoning, and the risk increases with lower temperature thresholds and longer cold wave durations. Cold wave warnings should be issued and corresponding protective policies should be formulated to reduce the potential risk of CO poisoning

A Murine Rp1 Missense Mutation Causes Protein Mislocalization and Slowly Progressive Photoreceptor Degeneration

Mutations in the RP1 gene can cause retinitis pigmentosa. We identified a spontaneous L66P mutation caused by two adjacent point mutations in the Rp1 gene in a colony of C57BL/6J mice. Mice homozygous for the L66P mutation exhibited slow, progressive photoreceptor degeneration throughout their lifespan. Optical coherence tomography imaging found abnormal photoreceptor reflectivity at 1 month of age. Histology found shortening and disorganization of the photoreceptor inner and outer segments and progressive thinning of the outer nuclear layer. Electroretinogram a- and b-wave amplitudes were decreased with age. Western blot analysis found that the quantity and size of the mutated retinitis pigmentosa 1 (RP1) protein were normal. However, immunohistochemistry found that the mutant Rp1 protein partially mislocalized to the transition zone of the shortened axonemes. This mutation disrupted colocalization with cytoplasmic microtubules in vitro. In conclusion, the L66P mutation in the first doublecortin domain of the Rp1 gene impairs Rp1 protein localization and function, leading to abnormalities in photoreceptor outer segment structure and progressive photoreceptor degeneration. This is the first missense mutation in Rp1 shown to cause retinal degeneration. It provides a unique, slowly progressive photoreceptor degeneration model that mirrors the slow degeneration kinetics in most patients with retinitis pigmentosa

Boundary Shape Inversion of Two-Dimensional Steady-State Heat Transfer System Based on Finite Volume Method and Decentralized Fuzzy Adaptive PID Control

A shape identification scheme was developed to determine the geometric shape of the inaccessible parts of two-dimensional objects using the measured temperatures on their accessible surfaces. The finite volume method was used to calculate the measured point&rsquo;s temperature in the forward problem. In the inversion problem, the decentralized fuzzy adaptive Proportion Integral Differential (PID) control (DFAC) algorithm was used to compensate for the inversion boundary by using the difference between the measurement temperature and the calculation temperature. More accurate inversion results were obtained by introducing the weighted and synthesized normal distribution. In the inversion problem, the effects of the initial guess, the number of measuring points, and the measurement error were studied. The experiment calculation and analysis showed that the methods adopted in this paper still maintain good validity and accuracy with different initial guesses and decrease the number of measuring points and the existence of measurement errors

Analytical Solution of Thermo–Mechanical Properties of Functionally Graded Materials by Asymptotic Homogenization Method

In this work, a general mathematical model for functionally graded heterogeneous equilibrium boundary value problems is considered. A methodology to find the local problems and the effective properties of functionally graded materials (FGMs) with generalized periodicity is presented, using the asymptotic homogenization method (AHM). The present models consist of the matrix metal Mo and the reinforced phase ceramic ZrC, the constituent ratios and the property gradation profiles of which can be described by the designed volume fraction. Firstly, a new threshold segmentation method is proposed to construct the gradient structure of the FGMs, which lays the groundwork for the subsequent research on the properties of materials. Further, a study of FGMs varied along a certain direction and the influence of the varied constituents and graded structures in the behavior of heterogeneous structures are investigated by the AHM. Consequently, the closed–form formulas for the effective thermo–mechanical coupling tensors are obtained, based on the solutions of local problems of FGMs with the periodic boundary conditions. These formulas provide information for the understanding of the traditional homogenized structure, and the results also be verified the correctness by the Mori–Tanaka method and AHM numerical solution. The results show that the designed structure profiles have great influence on the effective properties of the present inhomogeneous heterogeneous models. This research will be of great reference significance for the future material optimization design

Life Cycle Assessment of Plywood Manufacturing Process in China

Article no. 2037201

Convenient approach to synthesize tertiary α-hydroxy cyclic phosphonates catalyzed by potassium carbonate under solvent-free conditions

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