To Tube or Not to Tube? The Role of Intubation during Stroke Thrombectomy.

In the 10 years since the FDA first cleared the use of endovascular devices for the treatment of acute stroke, definitive evidence that such therapy improves outcomes remains lacking. The decision to intubate patients undergoing stroke thrombectomy impacts multiple variables that may influence outcomes after stroke. Three main areas where intubation may deleteriously affect acute stroke management include the introduction of delays in revascularization, fluctuations in peri-procedural blood pressure, and hypocapnia, resulting in cerebral vasoconstriction. In this mini-review, we discuss the evidence supporting these limitations of intubation during stroke thrombectomy and encourage neurohospitalists, neurocritical care specialists, and neurointerventionalists to carefully consider the decision to intubate during thrombectomy and provide strategies to avoid potential complications associated with its use in acute stroke

Calibration of GRB Luminosity Relations with Cosmography

For the use of Gamma-Ray Bursts (GRBs) to probe cosmology in a cosmology-independent way, a new method has been proposed to obtain luminosity distances of GRBs by interpolating directly from the Hubble diagram of SNe Ia, and then calibrating GRB relations at high redshift. In this paper, following the basic assumption in the interpolation method that objects at the same redshift should have the same luminosity distance, we propose another approach to calibrate GRB luminosity relations with cosmographic fitting directly from SN Ia data. In cosmography, there is a well-known fitting formula which can reflect the Hubble relation between luminosity distance and redshift with cosmographic parameters which can be fitted from observation data. Using the Cosmographic fitting results from the Union set of SNe Ia, we calibrate five GRB relations using GRB sample at $z\leq1.4$ and deduce distance moduli of GRBs at $1.4< z \leq 6.6$ by generalizing above calibrated relations at high redshift. Finally, we constrain the dark energy parameterization models of the Chevallier-Polarski-Linder (CPL) model, the Jassal-Bagla-Padmanabhan (JBP) model and the Alam model with GRB data at high redshift, as well as with the Cosmic Microwave Background radiation (CMB) and the baryonic acoustic oscillation (BAO) observations, and we find the $\Lambda$CDM model is consistent with the current data in 1-$\sigma$ confidence region.Comment: 15 pages, 4 figures, 2 tables; accepted for publication in IJMP

The Luminosity - E_p Relation within Gamma--Ray Bursts and Implications for Fireball Models

Using a sample of 2408 time-resolved spectra for 91 BATSE gamma-ray bursts (GRBs) presented by Preece et al., we show that the relation between the isotropic-equivalent luminosity (L_iso) and the spectral peak energy (E_p) in the cosmological rest frame, L_iso \propto E_p^2, not only holds within these bursts, but also holds among these GRBs, assuming that the burst rate as a function of redshift is proportional to the star formation rate. The possible implications of this relation for the emission models of GRBs are discussed. We suggest that both the kinetic-energy-dominated internal shock model and the magnetic-dissipation-dominated external shock model can well interpret this relation. We constrain the parameters for these two models, and find that they are in a good agreement with the parameters from the fittings to the afterglow data (abridged).Comment: 3 pages plus 5 figures, emulateapj style, accepted for publication in ApJ Letter

Spin Polarisability of the Nucleon in the Heavy Baryon Effective Field Theory

We have constructed a heavy baryon effective field theory with photon as an external field in accordance with the symmetry requirements similar to the heavy quark effective field theory. By treating the heavy baryon and anti-baryon equally on the same footing in the effective field theory, we have calculated the spin polarisabilities $\gamma_i, i=1...4$ of the nucleon at third order and at fourth-order of the spin-dependent Compton scattering. At leading order (LO), our results agree with the corresponding results of the heavy baryon chiral perturbation theory, at the next-to-leading order(NLO) the results show a large correction to the ones in the heavy baryon chiral perturbation theory due to baryon-antibaryon coupling terms. The low energy theorem is satisfied both at LO and at NLO. The contributions arising from the heavy baryon-antibaryon vertex were found to be significant and the results of the polarisabilities obtained from our theory is much closer to the experimental data.Comment: 21pages, title changed, minimal correction

Intermediate-Term Risk of Stroke Following Cardiac Procedures in a Nationally Representative Data Set.

BACKGROUND: Studies on stroke risk following cardiac procedures addressed only perioperative and long-term risk following limited higher-risk procedures, were poorly generalizable, and often failed to stratify by stroke type. We calculated stroke risk in the intermediate risk period following cardiac procedures compared with common noncardiac surgeries and medical admissions. METHODS AND RESULTS: The Nationwide Readmissions Database contains readmission data for 49% of US admissions in 2013. We compared age-adjusted stroke readmission rates up to 90 days postdischarge. We used Cox regression to calculate hazard ratios, up to 1 year, of stroke risk comparing transcatheter aortic valve replacement versus surgical aortic valve replacement and coronary artery bypass graft versus percutaneous coronary intervention. Procedures and diagnoses were identified by International Classification of Disease, Ninth Revision, Clinical Modification codes. After cardiac procedures, 90-day ischemic stroke readmission rate was highest after transcatheter aortic valve replacement (2.05%); 90-day hemorrhagic stroke rate was highest after left ventricular assist device placement (0.09%). The hazard ratio for ischemic stroke after transcatheter aortic valve replacement, compared with surgical aortic valve replacement, in fully adjusted Cox models was 1.86 (95% confidence interval, 1.12-3.08; P=0.016) and 6.17 (95% confidence interval, 1.97-19.33; P=0.0018) for hemorrhagic stroke. There was no difference between coronary artery bypass graft and percutaneous coronary intervention. CONCLUSIONS: We demonstrated elevated readmission rates for ischemic and hemorrhagic stroke in the intermediate 30-, 60-, and 90-day risk periods following common cardiac procedures. Furthermore, we found an elevated risk of stroke after transcatheter aortic valve replacement compared with surgical aortic valve replacement up to 1 year

Isospin breaking and f0(980)f_0(980)-a0(980)a_0(980) mixing in the η(1405)→π0f0(980)\eta(1405) \to \pi^{0} f_0(980) reaction

We make a theoretical study of the $\eta(1405) \to \pi^{0} f_0(980)$ and $\eta(1405) \to \pi^{0} a_0(980)$ reactions with an aim to determine the isospin violation and the mixing of the $f_0(980)$ and $a_0(980)$ resonances. We make use of the chiral unitary approach where these two resonances appear as composite states of two mesons, dynamically generated by the meson-meson interaction provided by chiral Lagrangians. We obtain a very narrow shape for the $f_0(980)$ production in agreement with a BES experiment. As to the amount of isospin violation, or $f_0(980)$ and $a_0(980)$ mixing, assuming constant vertices for the primary $\eta(1405)\rightarrow \pi^{0}K\bar{K}$ and $\eta(1405)\rightarrow \pi^{0}\pi^{0}\eta$ production, we find results which are much smaller than found in the recent experimental BES paper, but consistent with results found in two other related BES experiments. We have tried to understand this anomaly by assuming an I=1 mixture in the $\eta(1405)$ wave function, but this leads to a much bigger width of the $f_0(980)$ mass distribution than observed experimentally. The problem is solved by using the primary production driven by $\eta' \to K^* \bar K$ followed by $K^* \to K \pi$, which induces an extra singularity in the loop functions needed to produce the $f_0(980)$ and $a_0(980)$ resonances. Improving upon earlier work along the same lines, and using the chiral unitary approach, we can now predict absolute values for the ratio $\Gamma(\pi^0, \pi^+ \pi^-)/\Gamma(\pi^0, \pi^0 \eta)$ which are in fair agreement with experiment. We also show that the same results hold if we had the $\eta(1475)$ resonance or a mixture of these two states, as seems to be the case in the BES experiment