Geriatric syndromes and subsequent health-care utilization among older community dwellers in Stockholm

Little is known about the long-term effect of geriatric syndromes on health-care utilization. This study aims to determine the association between geriatric syndromes and health-care utilization during a four-year period among older community dwellers. Based on the Stockholm Public Health Cohort study, a total number of 6700 community dwellers aged ≥65 years were included. From a baseline survey in 2006, geriatric syndromes were defined as having at least one of the following: insomnia, functional decline, urinary incontinence, depressive symptoms and vision impairment. Health-care utilization was identified by linkages at individual level with register data with a four-year follow-up. Cox regression was performed to estimate the associations. Compared to those without geriatric syndromes, participants with any geriatric syndromes had a higher prevalence of frequent hospitalizations, long hospital stays, frequent outpatient visits and polypharmacy in each of the follow-up years. After controlling for covariates, having any geriatric syndromes was associated with higher levels of utilization of inpatient and outpatient care as well as polypharmacy. The association was stable over time, and the fully adjusted hazard ratio (95% confidence interval) remained stable in frequent hospitalizations (from 1.89 [1.31, 2.73] in year 1 to 1.70 [1.23, 2.35] in year 4), long hospital stay (from 1.75 [1.41, 2.16] to 1.49 [1.24, 1.78]), frequent outpatient visits (from 1.40 [1.26, 1.54] to 1.33 [1.22, 1.46]) and polypharmacy (from 1.63 [1.46, 1.83] to 1.53 [1.37, 1.71]). Having any geriatric syndromes is associated with higher levels of health-care utilization among older community dwellers, and the impact of geriatric syndromes is stable over a four-year period. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at. 10.1007/s10433-021-00600-2

A flat model structure on functor categories

In this paper we construct a flat model structure on the category $_{{\mathcal{Q}},A}{\rm Mod}$ of additive functors from a preadditive category ${\mathcal{Q}}$ satisfying certain conditions to the module category $_{A}{\rm Mod}$, whose homotopy category is the ${\mathcal{Q}}$-shaped derived category introduced by Holm and Jorgensen.Comment: 11 pages. Any comments are very welcom

Optimal scheduling for multiple description video streams in wireless multihop networks

International audience— In this work, we investigate the optimal system scheduling for competing multiple description (MD) video streams in a resource-limited wireless multihop network. By joint optimization of MD, rate control and multipath routing, optimal joint rate control and routing algorithm is proposed to solve this problem with constraints that arise from the MD streams among multiple users via multiple paths. We design this joint algorithm in a distributed manner that is amenable to on-line implementation for wireless networks

Tobacco use and second-hand smoke exposure in young adolescents aged 12–15 years: data from 68 low-income and middle-income countries

Tobacco use is an important risk factor for non-communicable diseases worldwide. However, the global extent and prevalence of tobacco use in adolescents is poorly described. Using previously collected survey data, we aimed to assess tobacco use and second-hand smoke exposure in young adolescents aged 12–15 years in 68 low-income and middle-income countries. Methods We used data from the Global School-based Student Health Survey (2006–13) and the China Global Tobacco Youth Survey (2013), which are school-based surveys of young adolescents aged 12–15 years that assess health behaviours using a standardised, anonymous, self-reported questionnaire. We calculated the prevalence of current tobacco use and exposure to second-hand smoke in young adolescents from 68 low-income and middle-income countries that collected these data in the surveys. We used a multilevel model to estimate the association between parental tobacco use, second-hand smoke, and adolescent tobacco use, adjusting for sex, age, school, school class, country's purchasing power parity, smoking initiation age, national prevalence of tobacco use among adults, year the WHO FCTC was ratified for each country, proxy of socioeconomic status, and survey year. Findings The mean prevalence of current tobacco use was 13·6%, ranging from 2·8% in Tajikistan to 44·7% in Samoa. In most countries, the prevalence of tobacco use was higher for boys than girls, and higher for adolescents aged 14–15 years than for those aged 12–13 years. The overall prevalence of second-hand smoke exposure was 55·9%, ranging from 16·4% in Tajikistan to 85·4% in Indonesia. Parental tobacco use (as reported by the young adolescents), especially maternal use, was associated with tobacco use in young adolescents (odds ratio 2·06, 95% CI 1·93–2·19, for maternal and 1·29, 1·23–1·35 for paternal use). Second-hand smoke exposure was also a risk factor for young adolescents' tobacco use (2·56, 2·43–2·69). However, the prevalence of tobacco use was not associated with a country's purchasing power parity. Interpretation Tobacco use and second-hand smoke exposure were frequent among young adolescents aged 12–15 years in low-income and middle-income countries. Parental tobacco use and second-hand smoke exposure were strongly associated with young adolescents' tobacco use. The data emphasise the need to strengthen tobacco control interventions and programmes in young adolescents from low-income and middle-income countries

Pharmacokinetics and bioequivalence evaluation of acamprosate calcium tablets in healthy Chinese volunteers

AbstractBackgroundFew pharmacokinetic data of acamprosate were available in Chinese population and no medication is approved for alcohol dependence in China.Purpose1. Investigate the pharmacokinetic properties of acamprosate calcium in healthy Chinese male volunteers on single- and multiple-dose administration. 2. Compare the bioequivalence of two formulations of acamprosate calcium tablets both under fasting and fed conditions.MethodsThis open-label, randomized study included 3 stages. In each stage, a 2-way crossover bioequivalence study was conducted to study the pharmacokinetic properties and bioequivalence of acamprosate calcium tablets on multiple dosing after standardized meals, single dosing under fasting conditions and fed conditions, respectively. The washout period between each treatment in a stage and between each stage was 1week. Plasma acamprosate calcium was quantified by a validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. Tolerability was evaluated by monitoring adverse events, physical examinations, 12-lead ECG, and laboratory tests.ResultsTotally, 36 male subjects were enrolled in the study and all of them completed the whole 3 study stages. Main pharmacokinetic parameters of test and reference formulations were as follows: multiple dosing, Tmax 9.94±6.59 and 9.47±5.47h, Cmax 435.74±348.10 and 346.54±155.66ng·mL−1, AUC0-t 8600.52±5264.77 and 9315.10±6820.03ng·mL−1·h, AUC0–∞ 8845.38±5838.18 and 9669.24±7326.53ng·mL−1·h, t1/2 10.06±8.83 and 9.87±10.35h; single dosing under fasting conditions, Tmax 7.29±4.87 and 6.57±1.85h, Cmax 247.85±110.05 and 244.64±132.43ng·mL−1, AUC0-t 3385.41±1418.92 and 3496.24±1767.29ng·mL−1·h, AUC0–∞ 3781.53±1556.96 and 3829.56±1981.25ng·mL−1·h, t1/2 13.07±17.24 and 10.26±7.78h; single dosing under fed conditions, Tmax 17.72±9.42 and 19.50±9.84h, Cmax 183.90±74.52 and 168.14±60.67ng·mL−1, AUC0-t 3181.71±1368.24 and 3575.11±1416.39ng·mL−1·h, AUC0–∞3442.39±2002.53 and 3624.44±1418.12ng·mL−1·h, t1/2 8.76±12.28 and 6.67±4.84h, respectively. In all three stages, 90% CIs for the test/reference ratio of AUC0–t and AUC0–∞ were located within 80%–125%, 90% CI for Cmax was within 70%–143%.ConclusionsSimilar pharmacokinetic results of acamprosate calcium tablets in healthy Chinese volunteers were found as those in Caucasic population. In all three stages, the two formulations met the regulatory criteria for bioequivalence.Chictr.org identifier: ChiCTR-TTRCC-14004853

CMTR: Cross-modality Transformer for Visible-infrared Person Re-identification

Visible-infrared cross-modality person re-identification is a challenging ReID task, which aims to retrieve and match the same identity's images between the heterogeneous visible and infrared modalities. Thus, the core of this task is to bridge the huge gap between these two modalities. The existing convolutional neural network-based methods mainly face the problem of insufficient perception of modalities' information, and can not learn good discriminative modality-invariant embeddings for identities, which limits their performance. To solve these problems, we propose a cross-modality transformer-based method (CMTR) for the visible-infrared person re-identification task, which can explicitly mine the information of each modality and generate better discriminative features based on it. Specifically, to capture modalities' characteristics, we design the novel modality embeddings, which are fused with token embeddings to encode modalities' information. Furthermore, to enhance representation of modality embeddings and adjust matching embeddings' distribution, we propose a modality-aware enhancement loss based on the learned modalities' information, reducing intra-class distance and enlarging inter-class distance. To our knowledge, this is the first work of applying transformer network to the cross-modality re-identification task. We implement extensive experiments on the public SYSU-MM01 and RegDB datasets, and our proposed CMTR model's performance significantly surpasses existing outstanding CNN-based methods.Comment: 11 pages, 7 figures, 7 table

Prevalence, trend and contributing factors of geriatric syndromes among older Swedes:results from the Stockholm County Council Public Health Surveys

BackgroundEvidence is scarce on the trend in prevalence of geriatric syndromes (GS). This study assesses how GS prevalence changes over time in Swedish older community-dwellers by socio-demography, and attempts to highlight factors that may contribute to explain the trend.MethodsData from Stockholm County Council Public Health Surveys in 2006, 2010 and 2014 were used. Old adults, aged 65-84years, with measurements on GS items were identified. Thus, a total of 17,560 participants were selected in 2006 (n=6295), 2010 (n=6733) and 2014 (n=4532). Data on socio-demographics, lifestyles and health status were collected through questionnaires. GS was defined as having at least one of the following: insomnia, urinary incontinence, severe hearing/vision problem, functional decline, fall and depressive disorder. Logistic regression was performed to assess the prevalence trend as well as the change in the associations of sociodemographic factors, health behaviors and chronic disease with GS.ResultsFrom 2006 to 2014, the prevalence of GS remained stable (P-trend=0.54). However, among old adults born outside Nordic countries, it increased significantly from 73.0% in 2006, 78.0% in 2010 to 83.0% in 2014 (P-trend0.05).ConclusionsAt population level, GS prevalence remained stable at a high level among Swedish old community-dwellers. There are noteworthy differences in GS trend between population groups, in particular to the detriment of older adults born outside Nordic countries

Trends in incidence of hypertension in Chinese adults, 1991–2009: The China Health and Nutrition Survey

Previous studies have shown an upward trend in the prevalence of hypertension, but data on trend of incidence of hypertension are lacking. We seek to investigate the trends in incidence of hypertension and control of incident hypertension among Chinese adults during 1991–1997 and 2004–2009