The Aging Heart: Mitophagy at the Center of Rejuvenation.

Aging is associated with structural and functional changes in the heart and is a major risk factor in developing cardiovascular disease. Many recent studies have focused on increasing our understanding of the basis of aging at the cellular and molecular levels in various tissues, including the heart. It is known that there is an age-related decline in cellular quality control pathways such as autophagy and mitophagy, which leads to accumulation of potentially harmful cellular components in cardiac myocytes. There is evidence that diminished autophagy and mitophagy accelerate the aging process, while enhancement preserves cardiac homeostasis and extends life span. Here, we review the current knowledge of autophagy and mitophagy in aging and discuss how age-associated alterations in these processes contribute to cardiac aging and age-related cardiovascular diseases

Macroscopic Quantum Coherence in Small Antiferromagnetic Particle and the Quantum Interference Effects

Starting from the Hamiltonian operator of the noncompensated two-sublattice model of a small antiferromagnetic particle, we derive the effective Lagrangian of a biaxial antiferromagnetic particle in an external magnetic field with the help of spin-coherent-state path integrals. Two unequal level-shifts induced by tunneling through two types of barriers are obtained using the instanton method. The energy spectrum is found from Bloch theory regarding the periodic potential as a superlattice. The external magnetic field indeed removes Kramers' degeneracy, however a new quenching of the energy splitting depending on the applied magnetic field is observed for both integer and half-integer spins due to the quantum interference between transitions through two types of barriers.Comment: 9 pages, Latex, 4 Postscript figure

The heavy-element abundances of AGB stars and the angular momentum conservation model of wind accretion for barium stars

Adpoting new s-process nucleosynthesis scenario and branch s-process path, we calculate the heavy-element abundances and C/O ratio of solar metallicity 3M_sun TP-AGB stars. The evolutionary sequence from M to S to C stars of AGB stars is explained naturally by the calculated results. Then combining the angular momentum conservation model of wind accretion with the heavy-element abundances on the surface of TP-AGB stars, we calculate the heavy-element overabundances of barium stars via successive pulsed accreting and mixing. Our results support that the barium stars with longer orbital period, P>1600 days, form through wind accretion scenario.Comment: 14 pages, LaTex, 17 PS figures included, accepted for publication in A &

Pigment identification with optical coherence tomography and multispectral imaging

We describe a new method for non-invasive pigment identification by combining the spectral reflectance in the visible spectrum with near infrared OCT cross-section images of the subsurface layer structure