Volume-averaged macroscopic equation for fluid flow in moving porous media

Darcy's law and the Brinkman equation are two main models used for creeping fluid flows inside moving permeable particles. For these two models, the time derivative and the nonlinear convective terms of fluid velocity are neglected in the momentum equation. In this paper, a new momentum equation including these two terms are rigorously derived from the pore-scale microscopic equations by the volume-averaging method, which can reduces to Darcy's law and the Brinkman equation under creeping flow conditions. Using the lattice Boltzmann equation method, the macroscopic equations are solved for the problem of a porous circular cylinder moving along the centerline of a channel. Galilean invariance of the equations are investigated both with the intrinsic phase averaged velocity and the phase averaged velocity. The results demonstrate that the commonly used phase averaged velocity cannot serve as the superficial velocity, while the intrinsic phase averaged velocity should be chosen for porous particulate systems

On the dynamic behavior and stability of controlled connected Rayleigh beams under pointwise output feedback

We study the dynamic behavior and stability of two connected Rayleigh beams that are subject to, in addition to two sensors and two actuators applied at the joint point, one of the actuators also specially distributed along the beams. We show that with the distributed control employed, there is a set of generalized eigenfunctions of the closed-loop system, which forms a Riesz basis with parenthesis for the state space. Then both the spectrum-determined growth condition and exponential stability are concluded for the system. Moreover, we show that the exponential stability is independent of the location of the joint. The range of the feedback gains that guarantee the system to be exponentially stable is identified

DESIGN AND OPTIMIZATION OF THE VARIABLE-DENSITY LATTICE STRUCTURE BASED ON LOAD PATHS

Lattice structure is more and more widely used in engineering by replacing solid structure. But its mechanical performances are constrained by the external shape if the unit cells are directly filled in the design domain, and the traditional topology optimization methods are difficult to give the explicitly mechanical guidance for the distribution of internal unit cells. In this paper, a novel design and optimization method of variable-density lattice structure is proposed in order to simultaneously optimize the external shape and the internal unit cells. First of all, the envelope model of any given structure should be established, and the load paths need to be visualized by the theory of load path. Then, the design criteria of external shape are established based on the principle of smoother load paths in the structure. An index of load flow capacity is defined to indicate the load paths density and to control the density distribution of unit cells, and a detailed optimization strategy is given. Finally, three examples of a cantilever plate, an L-shaped bracket and a classical three-point bending beam are used to verify the method. The results show that the models designed by the proposed method have better mechanical performances, lower material usage and less printing time

Signaling Mechanisms of Myofibroblastic Activation: Outside-in and Inside-Out

Myofibroblasts are central mediators of fibrosis. Typically derived from resident fibroblasts, myofibroblasts represent a heterogeneous population of cells that are principally defined by acquired contractile function and high synthetic ability to produce extracellular matrix (ECM). Current literature sheds new light on the critical role of ECM signaling coupled with mechanotransduction in driving myofibroblastic activation. In particular, transforming growth factor β1 (TGF-β1) and extra domain A containing fibronectin (EDA-FN) are thought to be the primary ECM signaling mediators that form and also induce positive feedback loops. The outside-in and inside-out signaling circuits are transmitted and integrated by TGF-β receptors and integrins at the cell membrane, ultimately perpetuating the abundance and activities of TGF-β1 and EDA-FN in the ECM. In this review, we highlight these conceptual advances in understanding myofibroblastic activation, in hope of revealing its therapeutic anti-fibrotic implications

Entropy-Based Model for Interpreting Life Systems in Traditional Chinese Medicine

Traditional Chinese medicine (TCM) treats qi as the core of the human life systems. Starting with a hypothetical correlation between TCM qi and the entropy theory, we address in this article a holistic model for evaluating and unveiling the rule of TCM life systems. Several new concepts such as acquired life entropy (ALE), acquired life entropy flow (ALEF) and acquired life entropy production (ALEP) are propounded to interpret TCM life systems. Using the entropy theory, mathematical models are established for ALE, ALEF and ALEP, which reflect the evolution of life systems. Some criteria are given on physiological activities and pathological changes of the body in different stages of life. Moreover, a real data-based simulation shows life entropies of the human body with different ages, Cold and Hot constitutions and in different seasons in North China are coincided with the manifestations of qi as well as the life evolution in TCM descriptions. Especially, based on the comparative and quantitative analysis, the entropy-based model can nicely describe the evolution of life entropies in Cold and Hot individuals thereby fitting the Yin–Yang theory in TCM. Thus, this work establishes a novel approach to interpret the fundamental principles in TCM, and provides an alternative understanding for the complex life systems

Expression of miR-126 and its potential function in coronary artery disease

Objective: This study aimed to explore the role of miR-126 in coronary artery disease (CAD) patients and the potential gene targets of miR-126 in atherosclerosis.Methodology: A total of 60 CAD patients and 25 healthy control subjects were recruited in this study. Among the 60 CAD patients, 18 cases were diagnosed of stable angina pectoris (SAP), 20 were diagnosed of unstable angina pectoris (UAP) and 22 were diagnosed of acute myocardial infarction (AMI). Plasma miR-126 levels from both groups of participants were analyzed by real-time quantitative PCR. ELISA was used to measure plasma level of placenta growth factor (PLGF).Results: The results showed that the miR-126 expression was significantly down-regulated in the circulation of CAD patients compared with control subjects (P<0.01). Plasma PLGF level was significantly upregulated in patients with unstable angina pectoris and acute myocardial infarction (AMI) compared with controls (both P<0.01) the miR-126 expression in AMI was significantly associated with PLGF.Conclusion: miR-126 may serve as a novel biomarker for CAD.Keywords: miR-126; PLGF; PCR; coronary artery disease; atherosclerosi