15,190 research outputs found
Attributed Network Embedding for Learning in a Dynamic Environment
Network embedding leverages the node proximity manifested to learn a
low-dimensional node vector representation for each node in the network. The
learned embeddings could advance various learning tasks such as node
classification, network clustering, and link prediction. Most, if not all, of
the existing works, are overwhelmingly performed in the context of plain and
static networks. Nonetheless, in reality, network structure often evolves over
time with addition/deletion of links and nodes. Also, a vast majority of
real-world networks are associated with a rich set of node attributes, and
their attribute values are also naturally changing, with the emerging of new
content patterns and the fading of old content patterns. These changing
characteristics motivate us to seek an effective embedding representation to
capture network and attribute evolving patterns, which is of fundamental
importance for learning in a dynamic environment. To our best knowledge, we are
the first to tackle this problem with the following two challenges: (1) the
inherently correlated network and node attributes could be noisy and
incomplete, it necessitates a robust consensus representation to capture their
individual properties and correlations; (2) the embedding learning needs to be
performed in an online fashion to adapt to the changes accordingly. In this
paper, we tackle this problem by proposing a novel dynamic attributed network
embedding framework - DANE. In particular, DANE first provides an offline
method for a consensus embedding and then leverages matrix perturbation theory
to maintain the freshness of the end embedding results in an online manner. We
perform extensive experiments on both synthetic and real attributed networks to
corroborate the effectiveness and efficiency of the proposed framework.Comment: 10 page
Baicalein and U0126 suppress bladder cancer proliferation via MAPK signaling pathway
Purpose: To investigate baicalein and 1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio] butadiene (U0126)effects on human bladder cell line T24 proliferation and related mechanisms.Methods: Twenty micromoles of baicalein or 10 μM U0126 were incubated with T24 cells. Cell viability was tested by CCK8 assay. Cell cycle was evaluated by flow cytometry while cell apoptosis was detected by Annexin V/PI and TUNEL assay. MAPK signaling pathway was evaluated by real time polymerase chain reaction (RT-PCR) and western blot.Results: Baicalein and U0126 suppressed bladder cancer cell T24 proliferation by blocking cell cycle in G0~G1 phase. TUNEL and Annexin V/PI detection showed both baicalein and U0126 induced T24 cell apoptosis. Baicalein and U0126 significantly down-regulated MAPK signaling pathway related molecule activity in both mRNA and protein levels (p < 0.05).Conclusion: Baicalein and U0126 restrain bladder cancer cell proliferation and promote cell apoptosis by affecting MAPK signaling pathway. Thus, they have potentials for use in the treatment of bladder cancer.Keywords: Bladder cancer, Baicalein, 1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio] butadiene, MAPK signal pathway, Apoptosi
Statistical Analysis on Large Scale Chinese Short Message Corpus and Automatic Short Massage Error Correction
PACLIC / The University of the Philippines Visayas Cebu College Cebu City, Philippines / November 20-22, 200
Unconventional Flatband Line States in Photonic Lieb Lattices
Flatband systems typically host "compact localized states"(CLS) due to
destructive interference and macroscopic degeneracy of Bloch wave functions
associated with a dispersionless energy band. Using a photonic Lieb
lattice(LL), we show that conventional localized flatband states are inherently
incomplete, with the missing modes manifested as extended line states which
form non-contractible loops winding around the entire lattice. Experimentally,
we develop a continuous-wave laser writing technique to establish a
finite-sized photonic LL with specially-tailored boundaries, thereby directly
observe the unusually extended flatband line states.Such unconventional line
states cannot be expressed as a linear combination of the previously observed
CLS but rather arise from the nontrivial real-space topology.The robustness of
the line states to imperfect excitation conditions is discussed, and their
potential applications are illustrated
MiR-196b-5p regulates the proliferation of drug-resistant hepatocellular carcinoma cell lines by activating NFκB/ABCB1 signaling pathway
Purpose: To explore the molecular function of miR-196b-5p in hepatocellular carcinoma (HCC).Methods: MiR-196b-5p expression levels in HCC tissue samples were assessed by qRT-PCR. MiR-196b-5p was knocked-down or over-expressed in HepG2 cells by transfecting the cells with plasmids expressing either a miR-196b-5p inhibitor or mimic, respectively, while cell proliferation was assessed by MTT assay. The interaction of miR-196b-5p with target molecules was confirmed using luciferase reporter assay. Cell cycle was investigated by flow cytometry, while NFκBIA expression was assessed by western blotting.Results: MiR-196b-5p was over-expressed in HCC, and miR-196b-5p expression levels in patients with HCC were related to tumor grade. MiR-196b-5p over-expression promoted cell proliferation and colony formation and suppressed cell cycle arrest and apoptosis. The results of luciferase reporter assay showed that miR-196b-5p reduced NFκBIA expression in HepG2 cells by binding to a response element in the 3′ UTR of NFκBIA. Further investigation showed that NFκBIA interacts with NFκB1 and reduces the concentration of NFκB1 in HepG2 cells. The promoter of ATP-binding cassette sub-family B member 1 (ABCB1) was also targeted and bound by NFκB1, which altered the expression of ABCB1 in HepG2 cells.Conclusion: MiR-196b-5p regulates cell proliferation in drug-resistant HCC cell lines via activation of the NFκB/ABCB1 signaling pathway.
Keywords: Hepatocellular carcinoma, miR-196b-5p, NFκBIA, NFκB1, ABCB
Temporal Pyramid Network for Pedestrian Trajectory Prediction with Multi-Supervision
Predicting human motion behavior in a crowd is important for many
applications, ranging from the natural navigation of autonomous vehicles to
intelligent security systems of video surveillance. All the previous works
model and predict the trajectory with a single resolution, which is rather
inefficient and difficult to simultaneously exploit the long-range information
(e.g., the destination of the trajectory), and the short-range information
(e.g., the walking direction and speed at a certain time) of the motion
behavior. In this paper, we propose a temporal pyramid network for pedestrian
trajectory prediction through a squeeze modulation and a dilation modulation.
Our hierarchical framework builds a feature pyramid with increasingly richer
temporal information from top to bottom, which can better capture the motion
behavior at various tempos. Furthermore, we propose a coarse-to-fine fusion
strategy with multi-supervision. By progressively merging the top coarse
features of global context to the bottom fine features of rich local context,
our method can fully exploit both the long-range and short-range information of
the trajectory. Experimental results on several benchmarks demonstrate the
superiority of our method.Comment: 9 pages, 5 figure
Baicalein inhibits the invasion of human cervical cancer cells by inhibiting the hedgehog/Gli signaling pathway
Purpose: To identify the role of baicalein in human cervical cancer and to determine whether baicalein treatment affects hedgehog/Gli signaling pathway.
Methods: Cell proliferation was evaluated by MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and colony formation assays. Cell death rate was assessed by PI-staining and FACS assay. Furthermore, cell invasion was assessed by Transwell assay while the levels of the key proteins were measured by western blotting analysis.
Results: Baicalein suppressed the viability and proliferation of HeLa cells. The colony formation ability and relative migration rate were significantly decreased in the HeLa cells treated with 50 μM baicalein. Furthermore, the levels of Shh, Gli1, MMP-9, and VEGF declined significantly in baicalein-treated cells.
Conclusion: The results demonstrate that baicalein inhibits the growth and invasiveness of cervical cancer cells partly by suppressing the activation of hedgehog/Gli signaling pathway in a concentrationdependent manner.
Keywords: Cervical cancer, baicalein, hedgehog/Gli pathway, MMP-
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