Characterizing Faint Submillimeter Galaxies with Cluster Lensing.

Ph.D. Thesis. University of Hawaiʻi at Mānoa 2017

An integrated approach with new strategies for QSAR models and lead optimization

Compound testing set for huAChE collected from Guo et al. (PDF 52 kb

Synthesis and Morphological Transformation of Conjugated Amphiphilic Diblock Copolymers in Mixed Solvents

The synthesis, morphological transformation, and photophysical properties of a rod-coil block copolymer, poly[2,7-(9,9-dihexylfluorene)]-block-poly(2-vinylpyridine) (PF-b-P2VP), with P2VP coils of various lengths in a mixed methanol/tetrahydrofuran (MeOH/THF) solvent are reported. Various morphological structures of PF-b-P2VP aggregates, including spheres, short worm-like structures, long cylinders, and large compound micelles (LCMs), were observed after varying the coil length of PF-b-P2VP and the selectivity of mixed solvents. These aggregated structures demonstrated considerable variation with regard to optical absorption, fluorescence, and the PL quantum yield of rod-coil copolymers. The degree of hypsochromic spectral shift was enhanced as the length of P2VP coils and the content of poor solvent increased. This study reveals the influence of coil length and selectivity of solvents on the morphology and the optical characteristics of rod-coil amphiphilic copolymers

High performance entanglement-assisted quantum LDPC codes need little entanglement

Though the entanglement-assisted formalism provides a universal connection between a classical linear code and an entanglement-assisted quantum error-correcting code (EAQECC), the issue of maintaining large amount of pure maximally entangled states in constructing EAQECCs is a practical obstacle to its use. It is also conjectured that the power of entanglement-assisted formalism to convert those good classical codes comes from massive consumption of maximally entangled states. We show that the above conjecture is wrong by providing families of EAQECCs with an entanglement consumption rate that diminishes linearly as a function of the code length. Notably, two families of EAQECCs constructed in the paper require only one copy of maximally entangled state no matter how large the code length is. These families of EAQECCs that are constructed from classical finite geometric LDPC codes perform very well according to our numerical simulations. Our work indicates that EAQECCs are not only theoretically interesting, but also physically implementable. Finally, these high performance entanglement-assisted LDPC codes with low entanglement consumption rates allow one to construct high-performance standard QECCs with very similar parameters.Comment: 8 pages, 5 figures. Published versio

Increased ATP generation in the host cell is required for efficient vaccinia virus production

To search for cellular genes up-regulated by vaccinia virus (VV) infection, differential display-reverse transcription-polymerase chain reaction (ddRT-PCR) assays were used to examine the expression of mRNAs from mock-infected and VV-infected HeLa cells. Two mitochondrial genes for proteins that are part of the electron transport chain that generates ATP, ND4 and CO II, were up-regulated after VV infection. Up-regulation of ND4 level by VV infection was confirmed by Western blotting analysis. Up-regulation of ND4 was reduced by the MAPK inhibitor, apigenin, which has been demonstrated elsewhere to inhibit VV replication. The induction of ND4 expression occurred after viral DNA replication since ara C, an inhibitor of poxviral DNA replication, could block this induction. ATP production was increased in the host cells after VV infection. Moreover, 4.5 μM oligomycin, an inhibitor of ATP production, reduced the ATP level 13 hr after virus infection to that of mock-infected cells and inhibited viral protein expression and virus production, suggesting that increased ATP production is required for efficient VV production. Our results further suggest that induction of ND4 expression is through a Bcl-2 independent pathway