MobiPlay: A Remote Execution Based Record-and-Replay Tool for Mobile Applications

The record-and-replay approach for software testing is important and valuable for developers in designing mobile applications. However, the existing solutions for recording and replaying Android applications are far from perfect. When considering the richness of mobile phones\u27 input capabilities including touch screen, sensors, GPS, etc., existing approaches either fall short of covering all these different input types, or require elevated privileges that are not easily attained and can be dangerous. In this paper, we present a novel system, called MobiPlay, which aims to improve record-and-replay testing. By collaborating between a mobile phone and a server, we are the first to capture all possible inputs by doing so at the application layer, instead of at the Android framework layer or the Linux kernel layer, which would be infeasible without a server. MobiPlay runs the to-be-tested application on the server under exactly the same environment as the mobile phone, and displays the GUI of the application in real time on a thin client application installed on the mobile phone. From the perspective of the mobile phone user, the application appears to be local. We have implemented our system and evaluated it with tens of popular mobile applications showing that MobiPlay is efficient, flexible, and comprehensive. It can record all input data, including all sensor data, all touchscreen gestures, and GPS. It is able to record and replay on both the mobile phone and the server. Furthermore, it is suitable for both white-box and black-box testing

Improved production of chlorogenic acid from cell suspension cultures of Lonicera macranthoids

Purpose: To evaluate the potential of Lonicera macranthoides Hand. -Mazz. Yulei1 suspension culture system for enhanced production of the main secondary metabolite, chlorogenic acid.Methods: The callus of L. macranthoides Hand.-Mazz. “Yulei1” was suspension cultured in B5 liquid medium supplemented with different plant growth regulators. Biomass accumulation was calculated by weight method and chlorogenic acid production was measured using high performance liquid chromatography (HPLC). HPLC was carried out on C18 analytical column at 35 °C and the detection wavelength was set at 324 nm.Results: The results showed that maximum accumulation of biomass and chlorogenic acid were achieved 15 days after culture growth. The optimized conditions for biomass accumulation and chlorogenic acid production were 50 g/L of inoculum on fresh weight basis, B5 medium supplemented with plant growth regulators, 30 - 40 g/L sucrose and initial medium pH of 5.5. Maximum accumulation of chlorogenic acid and biomass were observed when the culture medium was supplemented with 2.0 mg/L6-BA. Optimal accumulation of chlorogenic acid was observed using combination of hormones 2.0 mg/L 6-Benzyladenine (BA) + 0.5 mg/L2, 4-Dichlorophenoxyacetic acid (2,4-D), while optimal accumulation of biomass was observed with 2.0 mg/L 6-BA + 2.0 mg/L2, 4-D. In addition, phenylalanine also contributed to the synthesis of chlorogenic acid at a concentration > 50 mg/L.Conclusion: Cell suspension cultures of L. macranthoides Hand.-Mazz. “Yulei1” have successfully been established. The findings provide a potential basis for large scale production of chlorogenic acid using cell suspension cultures of L. macranthoides.Keywords: Lonicera macranthoides, Cell suspension culture, Chlorogenic acid, Phenylalanine, Optimizatio

Spin alignment of vector mesons in heavy-ion collisions

Polarized quarks and antiquarks in high-energy heavy-ion collisions can lead to the spin alignment of vector mesons formed by quark coalescence. Using the relativistic spin Boltzmann equation for vector mesons derived from Kadanoff-Baym equations with an effective quark-meson model for strong interaction and quark coalescence model for hadronizaton, we calculate the spin density matrix element $\rho_{00}$ for $\phi$ mesons and show that anisotropies of local field correlations or fluctuations with respect to the spin quantization direction lead to $\phi$ meson's spin alignment. We propose that the local correlation or fluctuation of $\phi$ fields is the dominant mechanism for the observed the $\phi$ meson's spin alignment and its strength can be extracted from experimental data as functions of collision energies. The calculated transverse momentum dependence of $\rho_{00}$ agrees with STAR's data. We further predict the azimuthal angle dependence of $\rho_{00}$ which can be tested in future experiments.Comment: ReVTex 4.1, 14 pages, 4 figures. A large part of the paper has been rewritten with the focus on extracting local correlations or fluctuations of phi fields from STAR's data and predictions for dependences of $\rho_{00}$ on the transverse momentum and azimuthal angl

Self-Assembly of Isostatic Self-Dual Colloidal Crystals

Self-dual structures whose dual counterparts are themselves possess unique hidden symmetry, beyond the description of classical spatial symmetry groups. Here we propose a strategy based on { a nematic monolayer of} attractive half-cylindrical colloids to self-assemble these exotic structures. { This system can be seen as a 2D system of semi-disks.} By using Monte Carlo simulations, we discover two isostatic self-dual crystals, i.e., an unreported crystal with pmg {space-group} symmetry and the twisted Kagome crystal. For the pmg crystal approaching the critical point, we find the double degeneracy of the {full} phononic spectrum at the self-dual point, and the merging of two tilted Weyl nodes into one \emph{critically-tilted} Dirac node. The latter is `accidentally' located on the high-symmetry line. The formation of this unconventional Dirac node is due to the emergence of the critical flat bands at the self-dual point, which are linear combinations of \emph{finite-frequency} floppy modes. These modes can be understood as mechanically-coupled self-dual rhomb chains vibrating in some unique uncoupled ways. Our work paves the way for designing and fabricating self-dual materials with exotic mechanical or phononic properties.Comment: 6 pages, 3 figure

Duality,Hidden Symmetry and Dynamic Isomerism in 2D Hinge Structures

Recently, a new type of duality was reported in some deformable mechanical networks which exhibit Kramers-like degeneracy in phononic spectrum at the self-dual point. In this work, we clarify the origin of this duality and propose a design principle of 2D self-dual structures with arbitrary complexity. We find that this duality originates from the (PCI) symmetry of the hinge, which belongs to a more general end-fixed scaling transformation. This symmetry gives the structure an extra degree of freedom without modifying its dynamics. This results in , i.e., dissimilar 2D mechanical structures, either periodic or aperiodic, having identical dynamic modes, based on which we demonstrate a new type of wave-guide without reflection or loss. Moreover, the PCI symmetry allows us to design various 2D periodic isostatic networks with hinge duality. At last, by further studying a 2D non-mechanical magnonic system, we show that the duality and the associated hidden symmetry should exist in a broad range of Hamiltonian systems.Comment: 6 pages, 4 figure

Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy improves survival of gastric cancer with peritoneal carcinomatosis: evidence from an experimental study

<p>Abstract</p> <p>Background</p> <p>Cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has been considered as a promising treatment modality for gastric cancer with peritoneal carcinomatosis (PC). However, there have also been many debates regarding the efficacy and safety of this new approach. Results from experimental animal model study could help provide reliable information. This study was to investigate the safety and efficacy of CRS + HIPEC to treat gastric cancer with PC in a rabbit model.</p> <p>Methods</p> <p>VX2 tumor cells were injected into the gastric submucosa of 42 male New Zealand rabbits using a laparotomic implantation technique, to construct rabbit model of gastric cancer with PC. The rabbits were randomized into control group (n = 14), CRS alone group (n = 14) and CRS + HIPEC group (n = 14). The control group was observed for natural course of disease progression. Treatments were started on day 9 after tumor cells inoculation, including maximal removal of tumor nodules in CRS alone group, and maximal CRS plus heperthermic intraperitoneal chemoperfusion with docetaxel (10 mg/rabbit) and carboplatin (40 mg/rabbit) at 42.0 ± 0.5°C for 30 min in CRS + HIPEC group. The primary endpoint was overall survival (OS). The secondary endpoints were body weight, biochemistry, major organ functions and serious adverse events (SAE).</p> <p>Results</p> <p>Rabbit model of gastric cancer with PC was successfully established in all animals. The clinicopathological features of the model were similar to human gastric PC. The median OS was 24.0 d (95% confidence interval 21.8 - 26.2 d ) in the control group, 25.0 d (95% CI 21.3 - 28.7 d ) in CRS group, and 40.0 d (95% CI 34.6 - 45.4 d ) in CRS + HIPEC group (<it>P </it>= 0.00, log rank test). Compared with CRS only or control group, CRS + HIPEC could extend the OS by at least 15 d (60%). At the baseline, on the day of surgery and on day 8 after surgery, the peripheral blood cells counts, liver and kidney functions, and biochemistry parameters were all comparable. SAE occurred in 0 animal in control group, 2 animals in CRS alone group including 1 animal death due to anesthesia overdose and another death due to postoperative hemorrhage, and 3 animals in CRS + HIPEC group including 1 animal death due to anesthesia overdose, and 2 animal deaths due to diarrhea 23 and 27 d after operation.</p> <p>Conclusions</p> <p>In this rabbit model of gastric cancer with PC, CRS alone could not bring benefit while CRS + HIPEC with docetaxel and carboplatin could significantly prolong the survival with acceptable safety.</p

Extraosseous (extramedullary) plasmacytomas: a clinicopathologic and immunophenotypic study of 32 Chinese cases

<p>Abstract</p> <p>Background</p> <p>Extraosseous plasmacytoma, so called extramedullary plasmacytoma (EMP) is relatively rare in China. The aim was investigate the clinicopathologic features of EMP and the role of Immunophenotype and genotype detection in diagnosis of EMP.</p> <p>Methods</p> <p>Thirty-two cases of EMP were investigated retrospectively by histopathology, immunophenotype, genotype and survival analysis.</p> <p>Results</p> <p>Clinically, the mean age of the patients was 53.4. Most of the patients received no treatment after the diagnosis was established, and the prognosis was relatively poor. Histologically, in 40% of the cases, the neoplastic cells were grade II or III. The neoplastic cells expressed one or more PC associated antigens. The immunophenotype of EMP and inflammation of sinonasal regions with numerous PC infiltrations were compared and showed some difference in expression of CD45, CD27, CD44v6 and Bcl-2 as well. Ig light chain restriction was detected in 87.5% of the cases.</p> <p>Conclusions</p> <p>we described 32 Chinese cases of EMP, compare with that reported in the literature, some differences are presented, including higher percentage of grade II and III cases, clinically inconsistent treatment and management as well as poor outcome of the disease.</p