Integrated Development and Parallelization of Automated Dicentric Chromosome Identification Software to Expedite Biodosimetry Analysis

Manual cytogenetic biodosimetry lacks the ability to handle mass casualty events. We present an automated dicentric chromosome identification (ADCI) software utilizing parallel computing technology. A parallelization strategy combining data and task parallelism, as well as optimization of I/O operations, has been designed, implemented, and incorporated in ADCI. Experiments on an eight-core desktop show that our algorithm can expedite the process of ADCI by at least four folds. Experiments on Symmetric Computing, SHARCNET, Blue Gene/Q multi-processor computers demonstrate the capability of parallelized ADCI to process thousands of samples for cytogenetic biodosimetry in a few hours. This increase in speed underscores the effectiveness of parallelization in accelerating ADCI. Our software will be an important tool to handle the magnitude of mass casualty ionizing radiation events by expediting accurate detection of dicentric chromosomes

Explicit equations of the fake projective plane (a=7,p=2,∅,D3X7)(a=7,p=2,\emptyset,D_3 X_7)

We find explicit equations of the fake projective plane $(a=7,p=2,\emptyset,D_3 X_7)$, which lies in the same class as the fake projective plane $(a=7,p=2,\emptyset,D_3 2_7)$ with $21$ automorphisms whose equations were previously found by Borisov and Keum. The method involves finding a birational model of a common Galois cover of these two surfaces.Comment: 12 pages. The relevant Mathematica, Magma, Macaulay2 codes and equations produced can be found in the ancillary folder and links in the bibliograph

Valley Carrier Dynamics in Monolayer Molybdenum Disulphide from Helicity Resolved Ultrafast Pump-probe Spectroscopy

We investigate the valley related carrier dynamics in monolayer MoS2 using helicity resolved non-degenerate ultrafast pump-probe spectroscopy at the vicinity of the high-symmetry K point under the temperature down to 78 K. Monolayer MoS2 shows remarkable transient reflection signals, in stark contrast to bilayer and bulk MoS2 due to the enhancement of many-body effect at reduced dimensionality. The helicity resolved ultrafast time-resolved result shows that the valley polarization is preserved for only several ps before scattering process makes it undistinguishable. We suggest that the dynamical degradation of valley polarization is attributable primarily to the exciton trapping by defect states in the exfoliated MoS2 samples. Our experiment and a tight-binding model analysis also show that the perfect valley CD selectivity is fairly robust against disorder at the K point, but quickly decays from the high-symmetry point in the momentum space in the presence of disorder.Comment: 15 pages,Accepted by ACS Nan

Security enhancement for NOMA-UAV networks

Owing to its distinctive merits, non-orthogonal multiple access (NOMA) techniques have been utilized in unmanned aerial vehicle (UAV) enabled wireless base stations to provide effective coverage for terrestrial users. However, the security of NOMA-UAV systems remains a challenge due to the line-of-sight air-to-ground channels and higher transmission power of weaker users in NOMA. In this paper, we propose two schemes to guarantee the secure transmission in UAV-NOMA networks. When only one user requires secure transmission, we derive the hovering position for the UAV and the power allocation to meet rate threshold of the secure user while maximizing the sum rate of remaining users. This disrupts the eavesdropping towards the secure user effectively. When multiple users require secure transmission, we further take the advantage of beamforming via multiple antennas at the UAV to guarantee their secure transmission. Due to the non-convexity of this problem, we convert it into a convex one for an iterative solution by using the second order cone programming. Finally, simulation results are provided to show the effectiveness of the proposed scheme

Impact of climate change on irrigation requirements in terms of groundwater resources

Climate change affects not only water resources but also water demand for irrigation. A large proportion of the world's agriculture depends on groundwater, especially in arid and semi-arid regions. In several regions, aquifer resources face depletion. Groundwater recharge has been viewed as a by-product of irrigation return flow, and with climate change, aquifer storage of such flow will be vital. A general review, for a broad-based audience, is given of work on global warming and groundwater resources, summarizing the methods used to analyze the climate change scenarios and the influence of these predicted changes on groundwater resources around the world (especially the impact on regional groundwater resources and irrigation requirements). Future challenges of adapting to climate change are also discussed. Such challenges include water-resources depletion, increasing irrigation demand, reduced crop yield, and groundwater salinization. The adaptation to and mitigation of these effects is also reported, including useful information for water-resources managers and the development of sustainable groundwater irrigation methods. Rescheduling irrigation according to the season, coordinating the groundwater resources and irrigation demand, developing more accurate and complete modeling prediction methods, and managing the irrigation facilities in different ways would all be considered, based on the particular case

Environmental and economic sustainability of key sectors in China's steel industry chain: An application of the Emergy Accounting approach

Abstract Increasing urbanization day–by–day requires new housing and transportation infrastructures. As a consequence, demand for steel – a basic material for buildings construction as well as for vehicles and railroads – would also increases. This study applies Emergy Accounting (EMA) to assess the Chinas steel industry environmental performance and to identify key application sectors. Subsequently, this study calculates emergy–based indicators capable to assess the present economic performance, environmental sustainability, and land resource appropriate utilization. Building on these indicators, changes of sustainability scenarios in key application sectors are also investigated, with special focus on increased use of recycled steel. The results show that the environmental impacts of steel use in downstream sectors, specially in the Housing and Vehicles Sectors, are significantly higher. Furthermore, the downstream sectors also have a very large requirement for embodied land. Additionally, the Emergy Benefit Ratio (EBR) shows non-negligible advantages to China derived from importing raw iron from abroad at international market prices. Finally, when the recycling rate of scrap steel increases, the performance of downstream sectors improves, with the Vehicle sector showing the most significant changes. Although the benefits of steel-based economy to society are clear, multidimensional sustainability concerns and international competition for primary resources necessitate a transition towards increased recycling and innovative materials within a strictly enforced "circular economy" policy

An Opposite Effect of the CDK Inhibitor, p18^INK4c on Embryonic Stem Cells Compared with Tumor and Adult Stem Cells

Self-renewal is a feature common to both adult and embryonic stem (ES) cells, as well as tumor stem cells (TSCs). The cyclin-dependent kinase inhibitor, p18INK4c, is a known tumor suppressor that can inhibit self-renewal of tumor cells or adult stem cells. Here, we demonstrate an opposite effect of p18 on ES cells in comparison with teratoma cells. Our results unexpectedly showed that overexpression of p18 accelerated the growth of mouse ES cells and embryonic bodies (EB); on the contrary, inhibited the growth of late stage teratoma. Up-regulation of ES cell markers (i.e., Oct4, Nanog, Sox2, and Rex1) were detected in both ES and EB cells, while concomitant down-regulation of various differentiation markers was observed in EB cells. These results demonstrate that p18 has an opposite effect on ES cells as compared with tumor cells and adult stem cells. Mechanistically, expression of CDK4 was significantly increased with overexpression of p18 in ES cells, likely leading to a release of CDK2 from the inhibition by p21 and p27. As a result, self-renewal of ES cells was enhanced. Our current study suggests that targeting p18 in different cell types may yield different outcomes, thereby having implications for therapeutic manipulations of cell cycle machinery in stem cells. © 2012 Li et al