Numerical convergence of pre-initial conditions on dark matter halo properties

Generating pre-initial conditions (or particle loads) is the very first step to set up a cosmological N-body simulation. In this work, we revisit the numerical convergence of pre-initial conditions on dark matter halo properties using a set of simulations which only differs in initial particle loads, i.e. grid, glass, and the newly introduced capacity constrained Voronoi tessellation (CCVT). We find that the median halo properties agree fairly well (i.e. within a convergence level of a few per cent) among simulations running from different initial loads. We also notice that for some individual haloes cross-matched among different simulations, the relative difference of their properties sometimes can be several tens of per cent. By looking at the evolution history of these poorly converged haloes, we find that they are usually merging haloes or haloes have experienced recent merger events, and their merging processes in different simulations are out-of-sync, making the convergence of halo properties become poor temporarily. We show that, comparing to the simulation starting with an anisotropic grid load, the simulation with an isotropic CCVT load converges slightly better to the simulation with a glass load, which is also isotropic. Among simulations with different pre-initial conditions, haloes in higher density environments tend to have their properties converged slightly better. Our results confirm that CCVT loads behave as well as the widely used grid and glass loads at small scales, and for the first time we quantify the convergence of two independent isotropic particle loads (i.e. glass and CCVT) on halo properties.Peer reviewe

You Need Multiple Exiting: Dynamic Early Exiting for Accelerating Unified Vision Language Model

Large-scale Transformer models bring significant improvements for various downstream vision language tasks with a unified architecture. The performance improvements come with increasing model size, resulting in slow inference speed and increased cost for severing. While some certain predictions benefit from the full complexity of the large-scale model, not all of inputs need the same amount of computation to conduct, potentially leading to computation resource waste. To handle this challenge, early exiting is proposed to adaptively allocate computational power in term of input complexity to improve inference efficiency. The existing early exiting strategies usually adopt output confidence based on intermediate layers as a proxy of input complexity to incur the decision of skipping following layers. However, such strategies cannot apply to encoder in the widely-used unified architecture with both encoder and decoder due to difficulty of output confidence estimation in the encoder. It is suboptimal in term of saving computation power to ignore the early exiting in encoder component. To handle this challenge, we propose a novel early exiting strategy for unified visual language models, which allows dynamically skip the layers in encoder and decoder simultaneously in term of input layer-wise similarities with multiple times of early exiting, namely \textbf{MuE}. By decomposing the image and text modalities in the encoder, MuE is flexible and can skip different layers in term of modalities, advancing the inference efficiency while minimizing performance drop. Experiments on the SNLI-VE and MS COCO datasets show that the proposed approach MuE can reduce expected inference time by up to 50\% and 40\% while maintaining 99\% and 96\% performance respectively

Marketing Budget Allocation with Offline Constrained Deep Reinforcement Learning

We study the budget allocation problem in online marketing campaigns that utilize previously collected offline data. We first discuss the long-term effect of optimizing marketing budget allocation decisions in the offline setting. To overcome the challenge, we propose a novel game-theoretic offline value-based reinforcement learning method using mixed policies. The proposed method reduces the need to store infinitely many policies in previous methods to only constantly many policies, which achieves nearly optimal policy efficiency, making it practical and favorable for industrial usage. We further show that this method is guaranteed to converge to the optimal policy, which cannot be achieved by previous value-based reinforcement learning methods for marketing budget allocation. Our experiments on a large-scale marketing campaign with tens-of-millions users and more than one billion budget verify the theoretical results and show that the proposed method outperforms various baseline methods. The proposed method has been successfully deployed to serve all the traffic of this marketing campaign.Comment: WSDM 23, Best Paper Candidat

Performance of the suspension method in large cross-section shallow-buried tunnels

Large cross-section tunnel construction induces ground surface settlements, potentially endangering both subterranean projects and nearby above-ground structures. A novel tunnel construction method, known as the suspension method, is introduced in this paper to mitigate surface settlement. The suspension method employs vertical tie rods to establish a structural connection between the initial tunnel support system and the surface steel beam, thereby exerting effective control settlements. To analyze the performance of the proposed method, systematic numerical simulations were conducted based on the practical engineering of Harbin Subway Line 3. The surface settlement and vault settlement characteristics during construction are investigated. The results show a gradual increment in both surface and vault settlement throughout the construction process, culminating in a stabilized state upon the completion of construction. In addition, compared to the double-side drift method and the Cross Diaphragm Method (CRD) method, the suspension method can obviously reduce the surface settlement and vault settlement. Moreover, the surface settlements and the axial force of tie rods were continuously monitored during the construction process at the trial tunnel block. These specific monitoring measurements are illustrated in comparison to numerical analysis results. The monitored results show great agreement with the numerical predictions, confirming the success of the project. This research can serve as a valuable practical reference for similar projects, offering insights and guidance for addressing ground surface settlements and enhancing construction safety in the domain of large cross-section tunneling

Numerical simulation study on suppression effect of water mist on PMMA combustion under external radiant heat flux

Numerical model was built with fire dynamic simulator and theocratical simulation was carried out to investigate the suppression effect of water mist on ignition and combustion process of typical solid material polymethyl methacrylate under external radiant heat flux. Characteristic parameters such as ignition time, surface temperature, heat release rate and temperature distribution of flame central plane during ignition and combustion process under different thermal radiant fluxes were obtained and compared with experimental results. The suppression effect of spray droplets on ignition and combustion process was analyzed and discussed. The results show the theoretical calculations of combustion characteristic parameters are in good agreement with experimental measurements. Water mist droplets can effectively delay the ignition time. Quantitative data proves that the water mist flow rate at 0.9 L/(min·m2) can delay the ignition time of samples by about 1,100 s while the radiant heat flux is 50 kW/m2. The simulation results can provide theoretical support and data reference for typical solid material fire prevention and fire extinguishment in practice

Current knowledge of thrombocytopenia in sepsis and COVID-19

Thrombocytopenia, characterized by a decrease in platelet count, is commonly observed in sepsis and COVID-19. In sepsis, thrombocytopenia can result from various mechanisms, including impaired platelet production in the bone marrow, accelerated platelet destruction due to increased inflammation, sequestration of platelets in the spleen, immune-mediated platelet destruction, or dysregulated host responses. Similarly, thrombocytopenia has been reported in COVID-19 patients, but the immune-related mechanisms underlying this association remain unclear. Notably, interventions targeting thrombocytopenia have shown potential for improving outcomes in both sepsis and COVID-19 patients. Understanding these mechanisms is crucial for developing effective treatments

Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis

<p>Abstract</p> <p>Background</p> <p>Proper patterning of the follicle cell epithelium over the egg chamber is essential for the <it>Drosophila </it>egg development. Differentiation of the epithelium into several distinct cell types along the anterior-posterior axis requires coordinated activities of multiple signaling pathways. Previously, we reported that <it>lethal(2)giant larvae </it>(<it>lgl</it>), a <it>Drosophila </it>tumor suppressor gene, is required in the follicle cells for the posterior follicle cell (PFC) fate induction at mid-oogenesis. Here we explore the role of another two tumor suppressor genes, <it>scribble </it>(<it>scrib</it>) and <it>discs large </it>(<it>dlg</it>), in the epithelial patterning.</p> <p>Results</p> <p>We found that removal of <it>scrib </it>or <it>dlg </it>function from the follicle cells at posterior terminal of the egg chamber causes a complete loss of the PFC fate. Aberrant specification and differentiation of the PFCs in the mosaic clones can be ascribed to defects in coordinated activation of the EGFR, JAK and Notch signaling pathways in the multilayered cells. Meanwhile, the clonal analysis revealed that loss-of-function mutations in <it>scrib/dlg </it>at the anterior domains result in a partially penetrant phenotype of defective induction of the stretched and centripetal cell fate, whereas specification of the border cell fate can still occur in the most anterior region of the mutant clones. Further, we showed that <it>scrib </it>genetically interacts with <it>dlg </it>in regulating posterior patterning of the epithelium.</p> <p>Conclusion</p> <p>In this study we provide evidence that <it>scrib </it>and <it>dlg </it>function differentially in anterior and posterior patterning of the follicular epithelium at oogenesis. Further genetic analysis indicates that <it>scrib </it>and <it>dlg </it>act in a common pathway to regulate PFC fate induction. This study may open another window for elucidating role of <it>scrib/dlg </it>in controlling epithelial polarity and cell proliferation during development.</p