Relational Research between China’s Marine S&T and Economy Based on RPGRA Model

To make up the defect of the existing model, an improved grey relational model based on radian perspective (RPGRA) is put forward. According to the similarity of the relative change trend of time series translating traditional grey relational degree into radian algorithm within different piecewise functions, it greatly improves the accuracy and validity of the research results by making full use of the poor information in time series. Meanwhile, the properties of the RPGRA were discussed. The relationship between China’s marine S&T and marine economy is researched using the new model, so the validity and creditability of RPGRA are illustrated. The empirical results show that marine scientific and technological research projects, marine scientific and technological patents granted, and research funds receipts of the marine scientific research institutions have greater relationship with GOP, which indicates that they have more impact on China’s marine economy

Bis(4-fluoro­benz­yl)bis­(4-phenyl-5-sulfanyl­idene-4,5-dihydro-1,3,4-thio­diazole-2-thiol­ato)tin(IV)

In the title complex, [Sn(C7H6F)2(C8H5N2S3)2], including the weak Sn—N inter­actions, the SnIV atom is situated in a distorted trans-octa­hedral geometry, and the equatorial plane is defined by two chelating 4-phenyl-5-sulfanyl­idene-4,5-dihydro-1,3,4-thio­diazole-2-thiol­ate ligands. The apical positions are occupied by two C atoms of 4-fluoro­benzyl groups

N′-[1-(4-Chloro­phen­yl)ethyl­idene]benzo­hydrazide

In the title mol­ecule, C15H13ClN2O, the two benzene rings form a dihedral angle of 5.48 (4)°. In the crystal, N—H⋯O hydrogen bonds link mol­ecules related by translation along the a axis into chains, which are further aggregated into layers parallel to the ac plane through weak C—H⋯O and C—H⋯N inter­actions

DeepsmirUD: Prediction of Regulatory Effects on microRNA Expression Mediated by Small Molecules Using Deep Learning

Aberrant miRNA expression has been associated with a large number of human diseases. Therefore, targeting miRNAs to regulate their expression levels has become an important therapy against diseases that stem from the dysfunction of pathways regulated by miRNAs. In recent years, small molecules have demonstrated enormous potential as drugs to regulate miRNA expression (i.e., SM-miR). A clear understanding of the mechanism of action of small molecules on the upregulation and downregulation of miRNA expression allows precise diagnosis and treatment of oncogenic pathways. However, outside of a slow and costly process of experimental determination, computational strategies to assist this on an ad hoc basis have yet to be formulated. In this work, we developed, to the best of our knowledge, the first cross-platform prediction tool, DeepsmirUD, to infer small-molecule-mediated regulatory effects on miRNA expression (i.e., upregulation or downregulation). This method is powered by 12 cutting-edge deep-learning frameworks and achieved AUC values of 0.843/0.984 and AUCPR values of 0.866/0.992 on two independent test datasets. With a complementarily constructed network inference approach based on similarity, we report a significantly improved accuracy of 0.813 in determining the regulatory effects of nearly 650 associated SM-miR relations, each formed with either novel small molecule or novel miRNA. By further integrating miRNA–cancer relationships, we established a database of potential pharmaceutical drugs from 1343 small molecules for 107 cancer diseases to understand the drug mechanisms of action and offer novel insight into drug repositioning. Furthermore, we have employed DeepsmirUD to predict the regulatory effects of a large number of high-confidence associated SM-miR relations. Taken together, our method shows promise to accelerate the development of potential miRNA targets and small molecule drugs

Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2

大多数真核生物的体细胞是二倍体，即仅含有两组染色体，分别遗传自父本和母本。而一些特定组织如心脏、肝脏等就含有多倍体细胞，特别是肝脏组织含有较高比例的四、八倍体等多倍体细胞。肝脏是人体的重要解毒器官，同时酒精、肝炎病毒等毒性物质或毒性代谢物容易诱发肝细胞的基因突变，多倍体被认为有利于提供代偿性的正常基因来维持肝脏稳态。然而肝脏受损后，多倍体细胞将会受胁迫进行增殖，再生修复受损的肝组织。因此研究机体调控多倍体细胞产生及多倍体细胞进行细胞分裂的调控机理对于理解肝癌的发病机理和肝癌的治疗至关重要。Hippo信号通路在调节组织成体干细胞的分化和增殖，调控器官再生与尺寸大小中具有重要作用。深入研究发现, Hippo信号通路下游效应分子YAP通过AKT-SKP2信号促进二倍体细胞向多倍体转化及多倍体细胞的生长增殖。本项研究阐明了Hippo缺失及YAP激活促进多倍体细胞产生及增殖作为肝癌发生发展中的一个重要机制，为肝癌诊疗提供了新的策略。 周大旺，博士，厦门大学生命科学学院教授、副院长、国家杰出青年基金获得者。【Abstract】Polyploidy can lead to aneuploidy and tumorigenesis. Here, we report that the Hippo pathway effector Yap promotes the diploid-polyploid conversion and polyploid cell growth through the Akt-Skp2 axis. Yap strongly induces the acetyltransferase p300-mediated acetylation of the E3 ligase Skp2 via Akt signaling. Acetylated Skp2 is exclusively localized to the cytosol, which causes hyper-accumulation of the cyclin-dependent kinase inhibitor p27, leading to mitotic arrest and subsequently cell polyploidy. In addition, the pro-apoptotic factors FoxO1/3 are overly degraded by acetylated Skp2, resulting in polyploid cell division, genomic instability, and oncogenesis. importantly, the depletion or inactivation of Akt or Skp2 abrogated Hippo signal deficiency-induced liver tumorigenesis, indicating their epistatic interaction. Thus, we conclude that Hippo-Yap signaling suppresses cell polyploidy and oncogenesis through Skp2.该研究工作获得了国家自然科学基金委、国家重点基础研究发展计划(973)项目、青年千人计划和中央高校基本科研基金的资助。 The Yap (S127A) transgenic mice were kindly provided by Dr. Fernando Camargo from Harvard Medical School, Boston, MA. D.Z. and L.C. were supported by the National Natural Science Foundation of China (31625010,U1505224, and J1310027 to D.Z.; 81422018, U1405225, and 81372617 to L.C.; 81472229 to L.H.), the National Basic Research Program (973) of China (2015CB910502 to L.C.), the Fundamental Research Funds for the Central Universities of China-Xiamen University (20720140551 to L.C. and 2013121034 and 20720140537 to D.Z.)

Fabrication of patterned carbon nanotubes with adjustable arrays through controlled mesoscopic dewetting

E-mail Addresses: [email protected], we report the synthesis of aligned carbon nanotube (CNT) bundles with adjustable arrays by a non-lithographic and low-cost strategy. A polystyrene/ferrocene patterns on silicon (Si) substrate was prepared through controlled mesoscopic dewetting of dilute polystyrene/ferrocene solution. A variety of regular patterns, including ladder, stripe and scale, were synthesized simply by changing the solution concentration. Ultraviolet (UV) irradiation effectively cross-linked polymer skeleton and made it suitable for structure-directing agent. In the sequent pyrolysis, polystyrene skeleton was decomposed and ferrocene was converted into the skeleton of inorganic patterns simultaneously. Aligned CNT bundles guided by the catalytically functionalized inorganic patterns were initiated to grow. This methodology opens up a new avenue for fabricating CNT arrays in a simple and controllable manner. Crown Copyright (c) 2012 Published by Elsevier Ltd. All rights reserved.National Natural Science Foundation of China 50703032 51035002 20974089 Program for New Century Excellent Talents of Ministry of Education of China NCET-08-0475 Natural Science Foundation of Fujian Province 2009J0602

Hippo信号通路通过调控Skp2活性从而抑制细胞多倍体产生及肝癌发生

文章简介在这项研究中,课题组揭示了Hippo信号通路在限制肝脏细胞的染色体由两倍体向多倍/非整倍体转变过程中起关键作用,该机制异常将导致基因组不稳定继而诱发肝癌的发生发展。课题组通过对Hippo信号通路重要成员(WW45,Mst1/2,Lats1/2)肝脏特异性敲除和过表达国家自然科学基金委;;国家重点基础研究发展计划(973)项目;;青年千人计划;;中央高校基本科研基金的资

Honeycomb-Patterned Hybrid Films and Their Template Applications via A Tunable Amphiphilic Block Polymer/Inorganic Precursor System

通讯作者地址: Li,L(通讯作者),Xiamen Univ,Coll Mat, Xiamen 361005, Peoples R China 地址: 1. Xiamen Univ, Coll Mat, Xiamen 361005, Peoples R China 2. Xiamen Univ, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China 3. Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China 电子邮件地址: [email protected], we show a facile and versatile method-prepare highly ordered inorganic patterns on solid substrates by pyrolyzing UV cross-linked polymr/functional. precursor hybrid films. The crosslinked polymer matrix acted as structure-directing agent in a pyrolyzing process, whereas the functional precursor was converted into the skeleton of the micropatterns. The inorganic micropatterns could be further catalytically functionalized to grow CNT and ZnO nanorod arrays by simply changing different functional precursors. This simple technique offers new prospects in the field of micropatterns, nanolithography, and template.National Natural Science Foundation of China,50703032,20974089;Natural Science Foundation of Fujian Province,2009J06029; Ministry of Education of Chin

Fabrication of multi-level carbon nanotube arrays with adjustable patterns

通讯作者地址: Li, L (通讯作者),Xiamen Univ, Coll Mat, Xiamen 361005, Peoples R China 地址: 1. Xiamen Univ, Coll Mat, Xiamen 361005, Peoples R China 2. Xiamen Univ, Coll Chem & Chem Engn, Xiamen, Peoples R China 3. Natl Inst Adv Ind Sci & Technol, Next Generat Device Team, Res Ctr Photovolta Technol, Tsukuba, Ibaraki 3058568, Japan 电子邮件地址: [email protected] carbon nanotube (CNT) arrays with adjustable patterns were prepared by a combination of the breath figure (BF) process and chemical vapor deposition. Polystyrene-b-poly(acrylic acid)/ferrocene was dissolved in carbon disulfide and cast onto a Si substrate covered with a transmission electron microscope grid in saturated relative humidity. A two-level microporous hybrid film with a block copolymer skeleton formed on the substrate after evaporation of the organic solvent and water. One level of ordered surface features originates from the contour of the hard templates; while the other level originates from the condensation of water droplets (BF arrays). Ultraviolet irradiation effectively cross-linked the polymer matrix and endowed the hybrid film with improved thermal stability. In the subsequent pyrolysis, the incorporated ferrocene in the hybrid film was oxidized and turned the polymer skeleton into the ferrous inorganic micropatterns. Either the cross-linked hybrid film or the ferrous inorganic micropatterns could act as a template to grow the multi-level CNT patterns, e. g. isolated and honeycomb-structured CNT bundle arrays perpendicular to the substrate.National Natural Science Foundation of China 50703032 51035002 20974089 Ministry of Education of China NCET-08-0475 Natural Science Foundation of Fujian Province 2009J0602