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Hippo信号通路通过调控Skp2活性从而抑制细胞多倍体产生及肝癌发生
Authors
Chengyan Liu
Daming Gao
+22 more
Jing Geng
Keiich I.Nakayama
Keiko Nakayama
Kwang-Huei Lin
Liang Zhu
Lixin Hong
Qiao Wu
Qiyuan Li
Randy L.Johnson
Suyuan Ji
Weiji Zhang
Xianming Deng
Xiufeng Sun
Yuanyuan Zeng
Yuxi Li
Zhen-Yu Yin
Zhonglei Lu
刘清许
周大旺
张世浩
陈兰芬
陈青花
Publication date
25 April 2018
Publisher
Abstract
文章简介在这项研究中,课题组揭示了Hippo信号通路在限制肝脏细胞的染色体由两倍体向多倍/非整倍体转变过程中起关键作用,该机制异常将导致基因组不稳定继而诱发肝癌的发生发展。课题组通过对Hippo信号通路重要成员(WW45,Mst1/2,Lats1/2)肝脏特异性敲除和过表达国家自然科学基金委;;国家重点基础研究发展计划(973)项目;;青年千人计划;;中央高校基本科研基金的资
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Last time updated on 10/06/2020