Transplanted olfactory ensheathing cells promote regeneration of cut adult rat optic nerve axons

Transplantation of olfactory ensheathing cells into spinal cord lesions promotes regeneration of cut axons into terminal fields and functional recovery. This repair involves the formation of a peripheral nerve-like bridge in which perineurial-like fibroblasts are organized into a longitudinal stack of parallel tubular channels, some of which contain regenerating axons enwrapped by Schwann-like olfactory ensheathing cells. The present study examines whether cut retinal ganglion cell axons will also respond to these cells, and if so, whether they form the same type of arrangement. In adult rats, the optic nerve was completely severed behind the optic disc, and a matrix containing cultured olfactory ensheathing cells was inserted between the proximal and distal stumps. After 6 months, the transplanted cells had migrated for up to 10 mm into the distal stump. Anterograde labeling with cholera toxin B showed that cut retinal ganglion cell axons had regenerated through the transplants, entered the distal stump, and elongated for 10 mm together with the transplanted cells. Electron microscopy showed that a peripheral nerve-like tissue had been formed, similar to that seen in the spinal cord transplants. However, in contrast to the spinal cord, the axons did not reach the terminal fields, but terminated in large vesicle-filled expansions beyond which the distal optic nerve stump was reduced to a densely interwoven mass of astrocytic processes

Knowledge Management for Maintenance, Repair and Service of Manufacturing System

Manufacturing equipment, such as numerical controlled machines and assembly cranes, requires constant maintenance and service in their operating lifecycle. Equipment maintenance plays an important role in avoiding unexpected failures and ensuring production efficiency. During maintenance operations, much data is generated and stored in databases. It is essential for manufacturing companies to develop a system to integrate equipment condition monitoring, fault prediction and knowledge base to support maintenance decisions. A case study, carried out within a power generator manufacturing organisation, was conducted to understand what the maintenance process is and how maintenance knowledge is currently managed. It was concluded that maintenance process is less efficient, and maintenance records, stored within internal databases, are not consistent, which makes knowledge hard to share, learn from and reuse. This paper proposes a Knowledge Management System for Maintenance, Repair and Service in Manufacturing Systems to support better maintenance decision and improve maintenance efficiency

Linkage between Accretion Disks and Blazars

The magnetic field in an accretion disk is estimated assuming that all of the angular momentum within prescribed accretion disk radii is removed by a jet. The magnetic field estimated at the base of the jet is extrapolated to the blazar emission region using a model for a relativistic axisymmetric jet combined with some simplifying assumptions based on the relativistic nature of the flow. The extrapolated magnetic field is compared with estimates based upon the synchrotron and inverse Compton emission from three blazars, MKN 501, MKN 421 and PKS 2155-304. The magnetic fields evaluated from pure synchrotron self- Compton models are inconsistent with the magnetic fields extrapolated in this way. However, in two cases inverse Compton models in which a substantial part of the soft photon field is generated locally agree well, mainly because these models imply magnetic field strengths which are closer to being consistent with Poynting flux dominated jets. This comparison is based on estimating the mass accretion rate from the jet energy flux. Further comparisons along these lines will be facilitated by independent estimates of the mass accretion rate in blazars and by more detailed models for jet propagation near the black hole.Comment: Submiteed to the Astrophysics & Space Science special issue on the 5th Stromlo Symposiu