Structural inequalities emerging from a large wire transfers network

We aim to explore the connections between structural network inequalities and bank’s customer spending behaviours, within an entire national ecosystem made of natural persons (i.e., an individual human being) and legal entities (i.e., private or public organisations), different business sectors, and supply chains that span distinct geographical regions. We focus on Italy, that is among the wealthiest nations in the world, and also an example of a complex economic system. In particular, we had access to a large subset of anonymised and GDPR-compliant wire transfer data recorded from Jan 2016 to Dec 2017 by Intesa Sanpaolo, a leading banking group in the Eurozone, and the most important one in Italy.Intesa Sanpaolo wire transfers network exhibits a strong heavy-tailed behaviour and a giant component that grows continuously around the same core of the 1% highest degree nodes, and it also shows a general disassortative pattern, even if some ranges of degrees’ values stand out from the trend. Structural heterogeneity is explored further by means of a bow-tie analysis, that shows clearly that the majority of relevant, in terms of transferred amount, transactions is settled between a smaller set of nodes that are associated to legal entities and that mostly belong to the strongly connected component. This observation brings to a more comprehensive inspection of differences between Italian regions and business sectors, that could support the detection and the understanding of the interplay between supply chains.Our results suggest that there is a general flow of money that seems to stream down from higher degree legal entities to lower degree natural persons, crossing Italian regions and connecting different business sectors, and that is finally redistributed through expenses sharing within families and smaller communities. We also describe a reference dataset and an empirical contribution to the study on financial networks, focusing on finer-grained information concerned about spending behaviour through wire transfers

TRPA1 mediates aromatase inhibitor-evoked pain by the aromatase substrate androstenedione

Aromatase inhibitors (AI) induce painful musculoskeletal symptoms (AIMSS), which are dependent upon the pain transducing receptor TRPA1. However, as the AI concentrations required to engage TRPA1 in mice are higher than those found in the plasma of patients, we hypothesized that additional factors may cooperate to induce AIMSS. Here we report that the aromatase substrate androstenedione, unique among several steroid hormones, targeted TRPA1 in peptidergic primary sensory neurons in rodent and human cells expressing the native or recombinant channel. Androstenedione dramatically lowered the concentration of letrozole required to engage TRPA1. Notably, addition of a minimal dose of androstenedione to physiologically ineffective doses of letrozole and oxidative stress byproducts produces AIMSS-like behaviors and neurogenic inflammatory responses in mice. Elevated androstenedione levels cooperated with low letrozole concentrations and inflammatory mediators were sufficient to provoke AIMSS-like behaviors. The generation of such painful conditions by small quantities of simultaneously administered TRPA1 agonists justifies previous failure to identify a precise link between AIs and AIMSS, underscoring the potential of channel antagonists to treat AIMSS

[Heart ischemia and psychosomatics: the role of stressful events and lifestyles].

Objective: the aim of our study was to evaluate the role of stressful events, lifestyles and various socio-environmental factors in the beginning of ischemic cardiac diseases, together with cardiovascular factors. Materials and methods: 64 patients with recent cardiac ischemia and 64 controls matched 1:1, according to their sex and age, have been evaluated. The study required the filling in of clinico-anamnestic reports and the evaluation of stressful events, using the Holmes Rahe scale. Results: in the 44% of the patients who had a heart ischemia, an emotional striking event occurred few days before, with a 28% incidence of work and family problems. The mean score of the Holmes Rahe Social Readjustment Rating Scale was statistically significantly higher among cases (p<0,05). The percentage of the subjects who experienced a stressful event during the last year was significantly higher among those with an ischemic event even though the heart disease factors were similar in the 2 groups of cases and controls. Conclusions: although the known heart risk factors predispose to ischemic event, our results suggest that stressful and emotional factors play a fundamental role in increasing the risk

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Status of the EU DEMO breeding blanket manufacturing R&D activities

The realization of a DEMOnstration Fusion Power Reactor (DEMO) to follow ITER, with the capability of generating several hundred MW of net electricity and operating with a closed fuel-cycle by 2050, is viewed by Europe as the remaining crucial step towards the exploitation of fusion power. The EUROfusion Consortium, in the frame of the European Horizon 2020 Program, has been assessing four different breeding blanket concepts in view of selecting the reference one for DEMO. This paper describes technologies and manufacturing scenarios developed and envisaged for the four blanket concepts, including nuclear “conventional” assembly processes as GTAW, electron beam and laser welding, Hot Isostatic Pressing (HIP), and also more advanced (from the nuclear standpoint) technologies as additive manufacturing techniques. These developments are performed in conformity with international standards and/or design/manufacturing codes. Topics as the metallurgical weldability of EUROFER steel and the associated risks or the development of appropriate filler wire are discussed. The development of protective W-coating layers on First Wall, with Functionally Graded (FG) interlayer as compliance layer between W and EUROFER substrate, realized by Vacuum Plasma Spraying method, is also propounded. First layer systems showed promising layer adhesion, thermal fatigue and thermal shock properties. He-cooled mock-ups, representative of the First Wall with FG W/EUROFER coating are developed for test campaigns in the HELOKA facility under relevant heat fluxes.First elements of Double Walled Tubes (DWT) manufacturing and tube/plate assembly for the water cooled concept are given, comprising test campaign aiming at assessing their behaviour under corrosion.In addition, further development strategies are suggested

Status of the EU DEMO breeding blanket manufacturing R&D activities

The realization of a DEMOnstration Fusion Power Reactor (DEMO) to follow ITER, with the capability of generating several hundred MW of net electricity and operating with a closed fuel-cycle by 2050, is viewed by Europe as the remaining crucial step towards the exploitation of fusion power. The EUROfusion Consortium, in the frame of the European Horizon 2020 Program, has been assessing four different breeding blanket concepts in view of selecting the reference one for DEMO. This paper describes technologies and manufacturing scenarios developed and envisaged for the four blanket concepts, including nuclear “conventional” assembly processes as GTAW, electron beam and laser welding, Hot Isostatic Pressing (HIP), and also more advanced (from the nuclear standpoint) technologies as additive manufacturing techniques. These developments are performed in conformity with international standards and/or design/manufacturing codes. Topics as the metallurgical weldability of EUROFER steel and the associated risks or the development of appropriate filler wire are discussed. The development of protective W-coating layers on First Wall, with Functionally Graded (FG) interlayer as compliance layer between W and EUROFER substrate, realized by Vacuum Plasma Spraying method, is also propounded. First layer systems showed promising layer adhesion, thermal fatigue and thermal shock properties. He-cooled mock-ups, representative of the First Wall with FG W/EUROFER coating are developed for test campaigns in the HELOKA facility under relevant heat fluxes. First elements of Double Walled Tubes (DWT) manufacturing and tube/plate assembly for the water cooled concept are given, comprising test campaign aiming at assessing their behaviour under corrosion. In addition, further development strategies are suggested

ForBioEnergy - Forest Bioenergy in the Protected Mediterranean Areas

ForBioEnergy project, funded in 2016 within the INTERREG MED Programme 2014 – 2020, involves a Lead Partner (Regional Department for the Rural and Territorial Development, Sicily Region), 8 project partners from 4 Mediterranean countries (Italy, Spain, Slovenia and Croatia) and 4 Associate Partners from Italy (Ente Parco delle Madonie, AIEL) and Croatia. The other Italian partners are Enviland s.r.l. and the municipality of Petralia Sottana. ForBioEnergy is an innovative project which bets on the chance to favour the sustainable development of the rural areas through the exploitation of the forest biomass for the production of bioenergy. In Mediterranean contexts, however, most of the forests are within protected areas, where the current regulatory restrictions as well as the lack of appropriate management plans impede and slow down the possibility to exploit woody biomass. The main objective of the project is fostering the bio-energy production in the protected areas, providing trans-national solutions for reducing barriers that currently hinder the development of the biomass sector, and planning models in order to exploit the full potential of woody biomass, whereas preserving the forest biodiversity. To achieve these goals the project include: (i) an Action Plan for shaping new regulatory framework and permit route aimed at removing the administrative, technical and socio-economic barriers that hinder the use of biomass; (ii) a multi-level planning process; (iii) a set of sustainability requirements and quality standards of forest biomass. During the project activities, the most significant gaps and the best practices will be identified through a trans-national process where key actors and stakeholders who deal with bioenergy and biodiversity issues are involved. Common challenges will be addressed through a participatory and shared process involving institutions, as well as social and productive organization at regional and local level. This objective will be pursued through the establishment of a permanent technical panel in each involved country with the aim of encouraging the exchange of knowledge and information between private and public key actors that operate in the bioenergy field. The project provides a three-level approach to the planning process for the use of forest biomass: 1) sub-regional, useful for the connections with the large scale energy planning; 2) local, useful for the development of best practices for sustainable forest management; 3) operating, useful for planning and management of forest-wood-energy supply chain. The results achieved by the project up to now are: 1) Methodologies and tools for drawing up Forest Biomass Plans aimed at the bioenergy production in the protected areas. A Decision Support Systems (DSS) has been elaborated and tested in order to guide the competent public authorities in the choice of the best solutions to increase the sustainable production of biomass in accordance with the sustainability objectives established for protected areas. GIS applications have been used for implementing the planning activities and for identifying the “Biomass Districts”; 2) Methodology for evaluating threats and benefits deriving from biomass harvesting and extraction. For this purpose, a set of specific indicators has been defined to evaluate the positive and negative impacts that the forestry interventions could have on the biotic, abiotic, and socio-economic components, in the short, medium and long period. Other activities in progress are: (i) drafting of a Action Plan to support the Public Authorities in the mitigation of the administrative and technical barriers that slow down the biomass use in the protected areas; (ii) drafting of a forest management plan at biomass district scale; (iii) definition of criteria for planning sustainable forest-wood-energy supply chains for the production of forest biomass in the protected areas; (iv) definition of a traceability system and quality standards for woody biomass in order to ensure the respect of the sustainability criteria necessary for the development of the biomass chain in the protected areas. The transferring activities, as well as the communicative ones, will contribute to spread the know-how and the results gained during the project implementation not only at a local level but also at a regional and national level, in order to favoring high levels of replicability all over the MED Programme cooperation area