1,177 research outputs found
A Study on the Historical Development of Chinaâs Sports Dream
Chinaâs sports dream was profoundly influenced by traditional Chinese culture in ancient China. At that time, the primary purpose of sports was bodybuilding, health preserving and entertainment. The ruling class never advocated even suppressed the phenomenon of emphasizing literacy and military force for the need of their ruling. In semi-colonial and semi-feudal old China, with the foreign invasion and inside corruption, modern sports were introduced to China and the Chinaâs sports dream had a strong sense of survival and participation. However, sports level as a whole was not high. At present, with the rejuvenation of Chinese nationâs âChinese Dreamâ, combining with Chinese excellent traditional culture, China plays a vital role in realizing Chinaâs sports dream, Â promoting Chinese sports soft power, shaping Chinaâs international sporting image, eliminating alienation in modern sports and establishing new international sports order
Difference operators on lattices
A differential operator of weight is the algebraic abstraction of
the difference quotient ,
including both the derivation as approaches to and the difference
operator when . Correspondingly, differential algebra of weight
extends the well-established theories of differential algebra and
difference algebra. In this paper, we initiate the study of differential
operators with weights, in particular difference operators, on lattices. We
show that differential operators of weight on a lattice coincide with
differential operators, while differential operators are special cases of
difference operators. Distributivity of a lattice is characterized by the
existence of certain difference operators. Furthermore, we characterize and
enumerate difference operators on finite chains and finite quasi-antichains.Comment: 19 page
Floroindole confers protection against cecal ligation and puncture-induced sepsis via inhibition of NF-kB p65 phosphorylation
Purpose: To investigate the protective effect of floroindole against cecal ligation and puncture (CLP)- induced sepsis, as well as the underlying mechanism of action.
Methods: Thirty-five 10âweek-old male Wistar rats weighing 190 - 210 g (mean: 200.00 ± 10.10 g) were used for this study. The rats were randomly assigned to seven groups of five rats each, viz, normal control group, and six CLP groups. The CLP groups were those subjected to cecal ligation and puncture (CLP). The first 5 CLP groups received 2, 4, 6, 8 or 10 mg/kg floroindole, respectively, 1 h after CLP, via intraperitoneal route (i.p.) while the 6th CLP group served as untreated control. Western blotting, enzyme-linked immunosorbent assay (ELISA) and real-time quantitative polymerase chain reaction (qRT-PCR) were used for the assessment of the expression levels of tumor necrosis factor-α (TNF- α), interleukn-6 (IL-6), nucleotide-binding oligomerization domain 2 (NOD2) and p-NF-ÎșB p65.
Results: Cecal ligation and puncture (CLP) significantly and time-dependently upregulated the expressions of TNF-α, IL-6 and NOD2 in intestinal tissues of rats (p < 0.05). However, treatment with floroindole significantly, and dose-dependently down-regulated CLP-induced expressions of these proteins (p < 0.05). Treatment of rats with floroindole also significantly and dose-dependently inhibited CLP-induced phosphorylation of NF-ÎșB p65 in rat ileum (p < 0.05).
Conclusion: The results obtained in this study demonstrate that floroindole confers some degree of protection against CLP-induced sepsis via inhibition of NF-ÎșB p65 phosphorylation
Prognostic value of routine laboratory variables in prediction of breast cancer recurrence.
The prognostic value of routine laboratory variables in breast cancer has been largely overlooked. Based on laboratory tests commonly performed in clinical practice, we aimed to develop a new model to predict disease free survival (DFS) after surgical removal of primary breast cancer. In a cohort of 1,596 breast cancer patients, we analyzed the associations of 33 laboratory variables with patient DFS. Based on 3 significant laboratory variables (hemoglobin, alkaline phosphatase, and international normalized ratio), together with important demographic and clinical variables, we developed a prognostic model, achieving the area under the curve of 0.79. We categorized patients into 3 risk groups according to the prognostic index developed from the final model. Compared with the patients in the low-risk group, those in the medium- and high-risk group had a significantly increased risk of recurrence with a hazard ratio (HR) of 1.75 (95% confidence interval [CI] 1.30-2.38) and 4.66 (95% CI 3.54-6.14), respectively. The results from the training set were validated in the testing set. Overall, our prognostic model incorporating readily available routine laboratory tests is powerful in identifying breast cancer patients who are at high risk of recurrence. Further study is warranted to validate its clinical application
Frequent mental distress among adults in the United States and its association with socio-demographic characteristics, unhealthy lifestyle, and chronic physical health status
Frequent mental distress (FMD) is a measure of poor mental health days for at least 14 days out of 30 days. It is one of the important dimensions of the health-related quality of life. The underlying causes of FMD are diverse. However, the issue has not been explored extensively due to the lack of reliable data on mental health. The aim of this study was to examine the level and trends of FMD among the adults of the United States (US) and identify the socio-demographic, lifestyles, and chronic health outcomes related correlates of FMD. The data for the study was obtained from the publicly available 2019 Behavioral Risk Factor Surveillance System (BRFSS) in the US, covering a large sample of 418,268 adult respondents from all the 50 states and participating territories. Respondents from each state and territory were identified by selecting the telephone number from the telephone directory following a systematic sampling design. To examine the trends in the prevalence of FMD, data from the 2010-2018 BRFSS were also utilized. Both descriptive and inferential statistical techniques, including multiple logistic regression models were employed to analyze the data. Results indicated that about 12% of the adults in the US experienced FMD, and the prevalence of FMD is increasing overtime. Females, students, adults aged below 35 years, multiracial, less educated, single, low income, and underweight individuals were found to have a higher risk of FMD. FMD was found to be significantly associated with unhealthy lifestyles and chronic health conditions. This study findings highlight the importance of interventions for mental health promotion and mental illness prevention, substance use prevention, screening and treatment services of FMD, and increased provision of resources to address social and economic determinants of FMD
Dielectric Response of Sr Doped CaCuâTiâOââ Ceramics
Ca1âxSrxCu3Ti4O12 (x=0, 0.1, and 0.2) ceramics were fabricated and their dielectric properties were investigated. It was found that the dielectric constant significantly decreased with the increase of Sr content at low temperature region (\u3c250 K) and remained almost unchanged at high temperature region (\u3e250 K). Three sets of relaxation peaks were observed in electric modulus plots, which were considered to be associated with grains, domain boundaries, and grain boundaries, respectively. Through the analysis of the heights and calculated activation energies of the relaxation peaks, it is strongly believed that the suppressed dielectric constant is related to the change of domain boundaries with Sr doping. ©2007 American Institute of Physic
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