An Enhanced Grey Wolf Optimizer with Elite Inheritance and Balance Search Mechanisms

The Grey Wolf Optimizer (GWO) is recognized as a novel meta-heuristic algorithm inspired by the social leadership hierarchy and hunting mechanism of grey wolves. It is well-known for its simple parameter setting, fast convergence speed, and strong optimization capability. In the original GWO, there are two significant design flaws in its fundamental optimization mechanisms. Problem (1): the algorithm fails to inherit from elite positions from the last iteration when generating the next positions of the wolf population, potentially leading to suboptimal solutions. Problem (2): the positions of the population are updated based on the central position of the three leading wolves (alpha, beta, delta), without a balanced mechanism between local and global search. To tackle these problems, an enhanced Grey Wolf Optimizer with Elite Inheritance Mechanism and Balance Search Mechanism, named as EBGWO, is proposed to improve the effectiveness of the position updating and the quality of the convergence solutions. The IEEE CEC 2014 benchmark functions suite and a series of simulation tests are employed to evaluate the performance of the proposed algorithm. The simulation tests involve a comparative study between EBGWO, three GWO variants, GWO and two well-known meta-heuristic algorithms. The experimental results demonstrate that the proposed EBGWO algorithm outperforms other meta-heuristic algorithms in both accuracy and convergence speed. Three engineering optimization problems are adopted to prove its capability in processing real-world problems. The results indicate that the proposed EBGWO outperforms several popular algorithms.Comment: 51 pages, 21 tables, 16 figures, journa

Experimental and theoretical evidence for molecular forces driving surface segregation in photonic colloidal assemblies

Surface segregation in binary colloidal mixtures offers a simple way to control both surface and bulk properties without affecting their bulk composition. Here, we combine experiments and coarse-grained molecular dynamics (CG-MD) simulations to delineate the effects of particle chemistry and size on surface segregation in photonic colloidal assemblies from binary mixtures of melanin and silica particles of size ratio (Dlarge/Dsmall) ranging from 1.0 to similar to 2.2. We find that melanin and/or smaller particles segregate at the surface of micrometer-sized colloidal assemblies (supraballs) prepared by an emulsion process. Conversely, no such surface segregation occurs in films prepared by evaporative assembly. CG-MD simulations explain the experimental observations by showing that particles with the larger contact angle (melanin) are enriched at the supraball surface regardless of the relative strength of particle-interface interactions, a result with implications for the broad understanding and design of colloidal particle assemblies

Island-sensitivity of two different interpretations of why in Chinese

It has been assumed that the wh-element weishenme “why” in Chinese has two distinct interpretations: a reason reading, which typically yields yinwei “because”-answers, and a purpose reading, which typically triggers weile “in order to”-answers. It is claimed that the two interpretations differ in island sensitivity: the reason weishenme is sensitive to islands while the purpose weishenme is not. Assuming that the reason weishenme is a wh-adverb without finer internal structure, while the purpose weishenme is a wh-PP consisting of the preposition wei “for” and a wh-DP shenme “what,” this contrast in island sensitivity can be considered as an instance of a broader generalization: the so-called argument-adjunct asymmetry (or the DP-adverb asymmetry) of wh-in-situ island sensitivity. However, recent experimental studies provided mixed findings on whether the argument-adjunct asymmetry of wh-in-situ island sensitivity actually holds. The current study focuses on the two interpretations of weishenme “why/for what” in Chinese, and provides evidence using a formal acceptability judgment experiment that the two weishenmes are both sensitive to islands, contrary to previous generalizations. Our results provide further empirical challenge to the so-called argument-adjunct asymmetry of wh-in-situ island sensitivity

Fuzzy-NMS: Improving 3D Object Detection with Fuzzy Classification in NMS

Non-maximum suppression (NMS) is an essential post-processing module used in many 3D object detection frameworks to remove overlapping candidate bounding boxes. However, an overreliance on classification scores and difficulties in determining appropriate thresholds can affect the resulting accuracy directly. To address these issues, we introduce fuzzy learning into NMS and propose a novel generalized Fuzzy-NMS module to achieve finer candidate bounding box filtering. The proposed Fuzzy-NMS module combines the volume and clustering density of candidate bounding boxes, refining them with a fuzzy classification method and optimizing the appropriate suppression thresholds to reduce uncertainty in the NMS process. Adequate validation experiments are conducted using the mainstream KITTI and large-scale Waymo 3D object detection benchmarks. The results of these tests demonstrate the proposed Fuzzy-NMS module can improve the accuracy of numerous recently NMS-based detectors significantly, including PointPillars, PV-RCNN, and IA-SSD, etc. This effect is particularly evident for small objects such as pedestrians and bicycles. As a plug-and-play module, Fuzzy-NMS does not need to be retrained and produces no obvious increases in inference time

Effects of different extracts of Cremastra appendiculata (D. Don) Makino Cremastra appendiculata (D. Don) Makino on apoptosis of A549 cells

Purpose: To investigate the effect of different extracts of Cremastra appendiculata (D. Don) Makino onapoptosis of A549 cells, and the underlying mechanism.Methods: The contents of colchicine in ethyl acetate and n-butanol extracts of Cremastra appendiculata(D. Don) Makino were determined using high performance liquid chromatography (HPLC). Lung cancerA549 cells cultured in vitro were divided into blank control, standard colchicine and Cremastra appendiculata (D. Don) Makino extract groups. The effect of different extract concentrations on proliferation of the cells was determined using methyl thiazolyl diphenyl-tetrazolium (MTT) assay, while apoptosis of A549 cells induced by the extracts was evaluated by flow cytometry (FC).Results: Compared with the standard colchicine group, there was no colchicine in the n-butanol and ethyl acetate extracts of Cremastra appendiculata. Results from MTT assay showed that the extract inhibited the proliferation of A549 cells (p < 0.05). Flow cytometry results showed that ethyl acetate extract significantly enhanced apoptosis in A549 cells (p < 0.05). However, n-butanol extract had no significant effect on the apoptosis of A549 cells (p < 0.05).Conclusion: The ethyl acetate extract of Cremastra appendiculata (D. Don) Makino induces apoptosis in lung cancer A549 cells. Therefore, there is a need for further research and development of antitumor drugs from the extract of Cremastra appendiculata (D. Don) Makino. Keywords: Cremastra appendiculata (D. Don) Makino, Colchicine, A549 cells, Apoptosi

Response of species dominance and niche of plant community to wetland degradation along alpine lake riparian

Alpine wetland degradation threatens riparian biodiversity and ecological balance. Our study, conducted in July 2020 along the northern and eastern shores of Qinghai Lake, seeks to unravel the impacts of such degradation on plant species dominance and ecological niches, using advanced network analysis methods to explore the dynamics and survival strategies of plant species. We applied a space-to-time method to delineate three wetland degradation stage: a healthy swamp wetland, a slightly degraded wet meadow, and a degraded dry meadow. Six representative sampling points were chosen. At each point, three sample lines were randomly established, radiating outward from the center of the lake wetland, with each stage of degradation meticulously examined through three replicates to assess the plant communities in terms of species composition, plant height, coverage, and abundance. The results indicated: Species such as Kobresia tibetica and Leymus secalinus exhibit remarkable abundance across various stages of wetland degradation, indicating a robust tolerance to these conditions. This observation, coupled with the complexity of plant community structures in degrading wetlands, suggests that such intricacy cannot be solely attributed to the dominance of particular species. Instead, it is the result of a diverse array of species adapting to fluctuating water levels, which promotes increased species richness. Despite the prominence of species that exhibit rapid growth and reproduction, the ecological significance of less abundant species in contributing to the community’s complexity is also notable. Changes in habitat conditions due to wetland degradation facilitate both competitive and cooperative interactions among species, highlighting the dynamic nature of these ecosystems. Our analysis shows no significant linear relationship between the ecological niche overlap values and niche widths of plant species. However, the strategies employed by dominant species for competition and resource acquisition, as observed in the ecological niche overlap networks, underscore the adaptive capacity of plant communities. These insights underscore the need for tailored restoration strategies to conserve the biodiversity of alpine lake riparian ecosystems. This research not only sheds light on the resilience and adaptability of ecosystems in the Qinghai-Tibetan Plateau but also offers valuable lessons for the conservation of similar habitats worldwide. Our findings underscore the need for tailored restoration strategies to conserve the biodiversity of alpine lake riparian ecosystems. This research not only sheds light on the resilience and adaptability of ecosystems in the Qinghai-Tibetan Plateau but also offers valuable lessons for the conservation of similar habitats worldwide

Hawthorn with “homology of medicine and food”: a review of anticancer effects and mechanisms

Over the past few years, there has been a gradual increase in the incidence of cancer, affecting individuals at younger ages. With its refractory nature and substantial fatality rate, cancer presents a notable peril to human existence and wellbeing. Hawthorn, a medicinal food homology plant belonging to the Crataegus genus in the Rosaceae family, holds great value in various applications. Due to its long history of medicinal use, notable effects, and high safety profile, hawthorn has garnered considerable attention and plays a crucial role in cancer treatment. Through the integration of modern network pharmacology technology and traditional Chinese medicine (TCM), a range of anticancer active ingredients in hawthorn have been predicted, identified, and analyzed. Studies have shown that ingredients such as vitexin, isoorientin, ursolic acid, and maslinic acid, along with hawthorn extracts, can effectively modulate cancer-related signaling pathways and manifest anticancer properties via diverse mechanisms. This review employs network pharmacology to excavate the potential anticancer properties of hawthorn. By systematically integrating literature across databases such as PubMed and CNKI, the review explores the bioactive ingredients with anticancer effects, underlying mechanisms and pathways, the synergistic effects of drug combinations, advancements in novel drug delivery systems, and ongoing clinical trials concerning hawthorn’s anticancer properties. Furthermore, the review highlights the preventive health benefits of hawthorn in cancer prevention, offering valuable insights for clinical cancer treatment and the development of TCM with anticancer properties that can be used for both medicinal and edible purposes

Seismic Constraint From Vp/Vs Ratios on the Structure and Composition Across the Continent‐Ocean Transition Zone, South China Sea

At non-volcanic passive continental margins, seismic techniques often failed to uniquely define the nature of crustal domains. Here, we overcome this problem by studying the structure and composition of the continent-ocean transition (COT) in the Southwest Sub-basin of the South China Sea, using P and S wave seismic tomography and Vp/Vs ratios, providing unique constraints on lithology. Throughout the image domain, we can rule out large areas of exhumed mantle as Vp/Vs ratios are always <1.9 in the shallow basement layer. Instead, the COT is characterized by extended and fragmented continental crust, and possibly mafic aggregation at the bottom of the crust. In concert with observations from multichannel seismic reflection data, seismic velocities and Vp/Vs ratios suggest that the oldest oceanic crust was formed by starved magmatism, causing rugged basement, thin crust, nearly absent lower crust, and moderately serpentinized mantle below. Our results reveal that rifting occurred without un-roofing continental mantle