The asymptotic distribution of maxima of stationary random sequences under random replacing

In this paper, we investigated the effect on extreme of random replacing for a stationary sequence satisfying a type of long dependent condition and a local dependent condition, and derived the joint asymptotic distribution of maximum from the stationary sequence and the maximum from the random replacing sequence. We also provided several applications for our main results.Comment:

Lysine demethylase 1A exacerbates LPS-induced inflammation of vascular smooth muscle cells through modulation of NF-κB activation

Purpose: To study the effect of lysine demethylase 1A (LSD1) on inflammatory responses of vascular smooth muscle cells (VSMCs), and investigate the mechanism. Methods: VSMCs were treated with lipopolysaccharide (LPS). Overexpression and knockdown of LSD1 in VSMCs were performed by transfecting with LSD1 overexpression plasmid and small interfering RNAs (siRNAs), respectively. Western blot and quantitative real-time polymerase chain reaction (qRTPCR) were used to measure protein and mRNA levels. Enzyme-linked immunosorbent (ELISA) assay was used to determine the levels of inflammatory cytokines. Results: Phosphorylation of LSD1 (p-LSD1) was significantly increased in LPS-induced VSMCs. Monocyte chemoattractant protein-1 and IL-6 levels were also increased by LPS, but attenuated by LSD1 knockdown in VSMCs. Activation of NF-κB was increased by LPS, but was also decreased by LSD1 knockdown. Level of methylated p65 (p65-me) in VSMCs was increased by treatment with SET7/9 (p65 methyltransferase), but this effect was attenuated by overexpression of LSD1. Besides, the increased levels of MCP-1 and IL-6 induced by overexpression of LSD1 were reversed by NF-κB signaling inhibitor, PDTC. Conclusion: LSD1 exacerbates LPS-induced inflammation of VSMCs through NF-κB activation via p65 demethylation, which indicates that LSD1 might be a potential target for the treatment of cardiovascular diseases. Keywords: Vascular smooth muscle cells, Lysine demethylase 1A, Phosphorylation, NF-κB, p65, Demethylatio

Semidiscrete optical vortex droplets in quasi-phase-matched photonic crystals

A new scheme for producing semidiscrete self-trapped vortices (\textquotedblleft swirling photon droplets\textquotedblright ) in photonic crystals with competing quadratic ($\chi ^{(2)}$) and self-defocusing cubic ($\chi ^{(3)}$) nonlinearities is proposed. The photonic crystal is designed with a striped structure, in the form of spatially periodic modulation of the $\chi ^{(2)}$ susceptibility, which is imposed by the quasi-phase-matching technique. Unlike previous realizations of semidiscrete optical modes in composite media, built as combinations of continuous and arrayed discrete waveguides, the semidiscrete vortex droplets are produced here in the fully continuous medium. This work reveals that the system supports two types of semidiscrete vortex droplets, \textit{viz}., onsite- and intersite-centered ones, which feature, respectively, odd and even numbers of stripes, $\mathcal{N}$. Stability areas for the states with different values of $\mathcal{N}$ are identified in the system's parameter space. Some stability areas overlap with each others, giving rise to multistability of states with different $\mathcal{N}$. The coexisting states are mutually degenerate, featuring equal values of the Hamiltonian and propagation constant. An experimental scheme to realize the droplets is outlined, suggesting new possibilities for the long-distance transmission of structured light carrying orbital angular momentum in nonlinear media.Comment: 9 pages, 7 figures, and 82 reference

Effect of Blueberry Anthocyanins Malvidin and Glycosides on the Antioxidant Properties in Endothelial Cells

The objective of this research was to survey the antioxidant functional role of the main anthocyanins of blueberries in endothelial cells. Changes on the reactive oxygen species (ROS), xanthine oxidase-1 (XO-1), superoxide dismutase (SOD), and heme oxygenase-1 (HO-1) in cells of malvidin and the two glycosides were investigated. The results showed that these anthocyanins decreased the levels of ROS and XO-1 but increased the levels of SOD and HO-1. Glycosides improved the antioxidant capacity of malvidin to a great extent. The changes in the antioxidant properties of malvidin-3-glucoside were more pronounced than malvidin-3-galactoside. Variation in levels of malvidin-3-glucoside and malvidin-3-galactoside had a significant impact on antioxidant properties to different extents. It indicates that blueberries are a good resource of anthocyanins, which can protect cells from oxidative deterioration and use blueberry as a potential functional food to prevent diseases related to oxidative stress

Literature Review on SNS Recruitment

SNS recruitment has become one of the hot topics of scholars and business in the past ten years, the focus of which through literature search and analysis is about the present situation, operation mechanism, brand creation of employers, legal disputes and regulation.Cross-cultural research also gradually becomes a new trend. Foreign research in this topic gets enriched from different fields including information technology, sociology, psychology, management and economics. Questionnaire analysis, case study and comparative study are main research methods, that’s to say, normative research and empirical research can be beautifully reached. Compared it abroad, related study in China is lack of empirical research with the limits of time, database selection and research methods, this paper still needs to be improved and possible future research trend can be cross-cultural research, behavior analysis based on large data, corporate social responsibility of SNS and brand creation of employers

Research on the Protective Effect of Twin-groyne Arrangement on Riverbank

A curved channel with intersecting streams can be easily scoured by incoming flow, and the concave bank is badly damaged. This research showed that the twin-groyne could effectively adjust and optimize the flow velocity distribution, change the shape of the free water surface of the bend, prevent erosion, and promote silting on the concave bank, and it could provide a scouring and silting effect on the convex bank. When the spacing of twin-groyne was increased to more than four times the body length of the single-groyne (spur dike), the protective effect on the concave bank was weakened, and the scouring and silting effect of the convex bank was reduced. Excessive spacing of the twin-groyne could cause local erosion damage to the concave bank. When the distance exceeded the theoretical optimum, it was equivalent to the effect of single-groyne. With the increase in the submergence degree, the velocity of the concave bank decreased first and then increased, while the velocity of convex bank decreased continuously. The protective effect of a non-submerged twin-groyne with a dam spacing of four times the body length of the single-groyne was better than that of other conditions, and it is recommended to be used in practice

Larmor precession: observation and utilization for boosting the signal intensity of radio frequency glow discharge mass spectrometry

A novel magnet array system was constructed to use Larmor precession for boosting the signal intensity of rf-GD-MS. The enhancement mechanism with four magnet array devices of single block magnet and 2×2, 3×2, and 3×4 magnet arrays was simulated and studied by COMSOL Multiphysics Software 5.4.0 (COMSOL) to determine if the electrons in the discharge plasma could perform Larmor precession along the direction perpendicular to the magnetic field. Induced by Larmor precession, inelastic collisions between the primary electrons and sample produced numerous secondary electrons and further improved the ionization efficiency. Moreover, the fuzzy synthetic evaluation result predicted that the device with 3×2 magnet array would display the greatest enhancement effect among the four devices. Based on these theoretical studies, a magnet array system with four magnet array devices was fabricated and utilized for studies of two scintillation crystals BGO and PWO. The observations indicated that the signal intensities obtained for 209Bi and 208Pb with the magnet array system were 630-3600 times of that obtained without magnet, and were enhanced by a factor of 1.5-2.8 compared with a previously reported stacked magnetic device. Two NIST samples were used to validate the method, and the results suggested that relative errors were less than 10% and the lowest detection limit for the 3×2 magnet array could reach 0.0032μg•g−1. Furthermore, the magnet array enhancement system with Larmor precession offers an efficient and sensitive approach for the direct analysis of non-conducting materials