Exploring Users’ Intention to use QQ\u27s Various Functions based on Social Cognitive Theory

Based upon social cognitive theory, this study explores the effect of personal and environment factors on users’ intention to use QQ’s various functions. Online survey is used to collect data in China. The results show that relationship benefit, switching cost, compatibility and subjective norms can significantly affect users’ intention to use QQ’s various functions. Whereas image benefit, perceived advantage and popularity have no effect. Finally, we propose the theoretical contribution and practical implication of this study

Mechanism underlying synergic activation of Tyrosinase promoter by MITF and IRF4

Background: The transcription factor interferon regulatory factor 4 (IRF4) was identified to be involved in human pigmentation by genome-wide association studies (GWASs). The rs12203592-[T/C], which is located in intron 4 of IRF4, shows the strongest link to these pigmentation phenotypes including freckling, sun sensitivity, eye and hair color. Previous studies indicated a functional cooperation of IRF4 with Microphthalmia-associated transcription factor (MITF), a causing gene of Waardenburg syndrome (WS), to synergistically trans-activate Tyrosinase (TYR). However, the underlying mechanism is still unknown. Methods: To investigate the importance of DNA binding in the synergic effect of IRF4. Reporter plasmids with mutant TYR promoters was generated to locate the IRF4 DNA binding sites in the Tyrosinase minimal promoter. By building MITF and IRF4 truncated mutations plasmids, the necessary regions of the synergy functions of these two proteins were also located. Results: The cooperative effect between MITF and IRF4 was specific for TYR promoter. The DNA-binding of IRF4 was critical for the synergic function. IRF4 DNA binding sites in TYR promoter were identified. The Trans-activation domains in IRF4 (aa134-207, aa300-420) were both important for the synergic function, whereas the auto-mask domain (aa207-300) appeared to mask the synergic effect. Mutational analysis in MITF indicated that both DNA-binding and transcriptional activation domains were both required for this synergic effect. Conclusions: Here we showed that IRF4 potently synergized with MITF to activate the TYR promoter, which was dependent on DNA binding of IRF4. The synergic domains in both IRF4 and MITF were identified by mutational analysis. This identification of IRF4 as a partner for MITF in regulation of TYR may provide an important molecular function for IRF4 in the genesis of melanocytes and the pathogenic mechanism in WS

The effect of litter decomposition mostly depends on seasonal variation of ultraviolet radiation rather than species in a hyper-arid desert

Introduction: Ultraviolet (UV) radiation is believed to play a significant role in accelerating litter decomposition in water-limited ecosystems. Litter traits also influence the decomposition. However, the dominance of litter traits and ultraviolet radiation on litter decomposition in hyper-arid deserts (annual precipitation: potential evaporation < 0.05) with diverse species and seasonal variations remain unclear.Methods: To address this knowledge gap, we examined the decomposition of three dominant litter species (Karelinia caspia, Alhagi sparsifolia, and Populus euphratica) in the southern edge of the Taklimakan Desert, Northwest China.Results: Our results revealed that under UV radiation conditions, K. caspia, A. sparsifolia, and P. euphratica experienced mass losses of 45.4%, 39.8%, and 34.9%, respectively, and 20%, 22.2% and 17.4%, respectively under UV filtering treatment. Specifically, the loss rate of carbon and lignin under UV radiation, was 2.5 and 2.2 times higher than under UV filtering treatment, respectively.Conclusion: UV radiation did not dominate decomposition throughout the year in our study area, and the loss rate of litter traits was significantly higher in summer than in winter under UV radiation. Moreover, this photodegradation is related to the intensity of UV exposure, but not to precipitation or temperature. Surprisingly, species type had no significant effect on litter decomposition. However, when we applied a UV filtering treatment, we observed higher loss rates of nitrogen compared with the ambient treatment, suggesting the involvement of other spectra in the litter decomposition process. Overall, our findings elucidate that UV radiation is a crucial factor that affects litter mass loss. The magnitude of this effect mostly varies with the season rather than the species of litter

Personal Involvement Moderates Message Framing Effects on Food Safety Education among Medical University Students in Chongqing, China.

This study explored whether the efficacy of food safety education interventions can be increased by message framing among medical university students, and demonstrated the role of personal involvement within the message recipient in moderating framed effects. A cross-sectional study of food safety message framing was conducted among medical university students (randomly selected 1353 participants). An online self-administered questionnaire was used to collect information. Wilcoxon rank-sum test and Ordered multivariate logistic regression were utilised in the data analyses. The present study showed significant differences in acceptance between the gain- and loss-framed groups ( < 0.001). Participants with higher personal involvement had higher acceptance than those with low personal involvement in gain- and loss-framed message models ( < 0.001). The acceptance of participants who were concerned about their health condition was higher than those who were neutral regarding their health condition ( < 0.001) and participants who suffered a food safety incident had higher acceptance than those who did not ( < 0.05). This study portrayed the selection preference of message framing on food safety education among medical university students in southwest China. Participants exposed to loss-framed messages had higher message acceptance than those exposed to gain-framed messages. Personal involvement may affect the food safety message framing. Public health advocates and professionals can use framed messages as a strategy to enhance intervention efficacy in the process of food safety education

Evidence for Transgenerational Transmission of Epigenetic Tumor Susceptibility in Drosophila

Transgenerational epigenetic inheritance results from incomplete erasure of parental epigenetic marks during epigenetic reprogramming at fertilization. The significance of this phenomenon, and the mechanism by which it occurs, remains obscure. Here, we show that genetic mutations in Drosophila may cause epigenetic alterations that, when inherited, influence tumor susceptibility of the offspring. We found that many of the mutations that affected tumorigenesis induced by a hyperactive JAK kinase, HopTum-l, also modified the tumor phenotype epigenetically, such that the modification persisted even in the offspring that did not inherit the modifier mutation. We analyzed mutations of the transcription repressor Krüppel (Kr), which is one of the hopTum-l enhancers known to affect ftz transcription. We demonstrate that the Kr mutation causes increased DNA methylation in the ftz promoter region, and that the aberrant ftz transcription and promoter methylation are both transgenerationally heritable if HopTum-l is present in the oocyte. These results suggest that genetic mutations may alter epigenetic markings in the form of DNA methylation, which are normally erased early in the next generation, and that JAK overactivation disrupts epigenetic reprogramming and allows inheritance of epimutations that influence tumorigenesis in future generations

Effects of Goal-Framed Messages on Mental Health Education Among Medical University Students: Moderating Role of Personal Involvement.

Mental health problem among university students is an emerging public health issue, and mental health education has always been the focus of attention for universities. However, limited attention has been paid to the effect of students' acceptance of health messages. Previous studies have found that message framing plays a key role in the process of responding to health-promoting messages. In this backdrop, the study aimed to examine the effects of goal-framed messages on mental health education among medical university students and investigate the moderating role of personal involvement. A cross-sectional study was conducted on medical university students. An online self-administered questionnaire was used to collect data. Wilcoxon rank-sum test and ordinal logistic regression were used for data analysis. Results showed significant differences in message acceptance between the gain- and loss-framed groups ( < 0.001). Participants with high personal involvement had higher message acceptance than those with low personal involvement in gain- and loss-framed message models ( < 0.05). Specifically, participants who related to roommates with high intimacy had higher message acceptance than those who related to roommates generally ( < 0.05). Participants who were concerned about their health condition had higher message acceptance than those who were neutral about their health condition ( < 0.001). Evidence of advantages of gain- over loss-framed messages on mental health among medical university students was found. The hypothesis that personal involvement with a health issue affects the acceptance of message framing was supported. Public health advocates can use framed message as a strategy to improve the efficacy of intervention in mental health education