Study of self-assembling block co-polymer templated hydroxyapatite nanocomposites gel by urease enzymetic urea hydrolysis

This study aimed to develop a biomimetic approach to achieve the natural biomineralization of bone. Temperature and pH-sensitive self-assembling tri- and pentablock co-polymer templated Hydroxyapatite (Ca5(PO4)3OH) (HAp) nanocomposite hydrogels were synthesized, and enzyme-catalyzed urea decomposition was used to increase pH gradually and homogeneously. XRD, SEM, TEM and EDS analysis confirmed the formation of HAp. The hydrogels showed the existence of amorphous HAp. The inorganic phase exhibited thin sheet-like structure with a length of hundreds nanometers, and only 5-10 nm thick. Both high-resolution TEM and scanning TEM microimages, electron diffraction and SEM confirmed the nano-crystalline phase of HAp in dry state. The nano HAp sheets assembled to form clusters in the presence of polymer. The inorganic components account for 4-6 wt% of the total hydrogels. It is also proved by NMR that organic and inorganic components intimately associated with each other that formed nanocomposites. Samples prepared with Pluronic at 37oC showed smaller nanocomposite size than PAA. It is also found that by the same urea-urease method without polymer, low inorganic ion concentrations (0.2M and 0.4M) and low temperatures (room T and 37oC), resulted in mainly calcium carbonate (CaCO3, calcite) whereas for higher Ca2+ and PO43- concentrations and temperatures (i.e., 1.0M and 1.5M at 60oC), HAp was the dominant phase. The urease activity has been confirmed to be affected by high concentration of buffer phosphate solution. Low phosphate concentration may facilitate the urea hydrolysis to release CO2 at a faster rate which reacts with Ca2+ to form CaCO3

Helmert Variance Component Estimation for Multi-GNSS Relative Positioning

The Multi-constellation Global Navigation Satellite System (Multi-GNSS) has become the standard implementation of high accuracy positioning and navigation applications. It is well known that the noise of code and phase measurements depend on GNSS constellation. Then, Helmert variance component estimation (HVCE) is usually used to adjust the contributions of di¿erent GNSS constellations by determining their individual variances of unit weight. However, HVCE requires a heavy computation load. In this study, the HVCE posterior weighting was employed to carry out a kinematic relative Multi-GNSS positioning experiment with six short-baselines from day of year (DoY) 171 to 200 in 2019. As a result, the HVCE posterior weighting strategy improved Multi-GNSS positioning accuracy by 20.5%, 15.7% and 13.2% ineast-north-up(ENU) components, compared to an elevation-dependent (ED) priori weighting strategy. We observed that the weight proportion of both code and phase observations for each GNSS constellation were consistent during the entire 30 days, which indicates that the weight proportions of both code and phase observations are stable over a long period of time. It was also found that the quality of a phase observation is almost equivalent in each baseline and GNSS constellation, whereas that of a code observation is different. In order to reduce the time consumption off the HVCE method without sacrificing positioning accuracy, the stable variances of unit weights of both phase and code observations obtained over 30 days were averaged and then frozen as a priori information in the positioning experiment. The result demonstrated similar ENU improvements of 20.0%, 14.1% and 11.1% with respect to the ED method but saving 88% of the computation time of the HCVE strategy. Our study concludes with the observations that the frozen variances of unit weight (FVUW) could be applied to the positioning experiment for the next 30 days, that is, from DoY 201 to 230 in 2019, improving the positioning ENU accuracy of the ED method by 18.1%, 13.2% and 10.6%, indicating the effectiveness of the FVUW.Peer ReviewedPostprint (published version

Inter-system biases solution strategies in multi-GNSS kinematic precise point positioning

Estimating inter-system biases (ISBs) is important in multi-constellation Global Navigation Satellite System (GNSS) processing. The present study aims to evaluate and screen out an optimal estimation strategy of ISB for multi-GNSS kinematic precise point positioning (PPP). The candidate strategies considered for ISB estimation are white noise process (ISB-WN), random walk process (ISB-RW), constant (ISB-CT) and eliminated by between-satellite single-differenced observations (ISB-SD). We first present the mathematical model of ISB derived from the observation combination among different GNSSs, and we demonstrate the equivalence between ISB-WN and ISB-SD in the Kalman filter. In order to evaluate the performance of these four ISB solution strategies, we implement kinematic PPP with 1-month static data from 112 International GNSS service stations and two-hour dynamic vehicular data collected in an urban case. For comparison, precise orbit and clock products from the Center for Orbit Determination in Europe (CODE), GeoForschungsZentrum in Germany (GFZ) and Wuhan University (WHU) are employed in our experiments. The results of static tests show that the positioning accuracy is comparable among the four strategies, but ISB-CT performs slightly better in convergence time. In the kinematic test, there are more cycle slips than static test, and the ISB-CT improves the positioning accuracy by 15.7%, 38.9% and 63.2% in east, north and up components, and reduces the convergence time by 60.1% comparing with the other strategies. Moreover, both the static and kinematic tests prove the consistence among CODE, GFZ and WHU precise products and the equivalence between ISB-WN and ISB-SD strategies. Finally, more, i.e., the same amount of cycle slips as for the dynamic data, are artificially added to the static data to conduct the pseudo-kinematic test. The result shows that ISB-CT improves the positioning accuracy and convergence time by 19.2% and 24.4%, respectively.The study is funded by Laoshan Laboratory (LSKJ202205104, LSKJ202205104_01), National Key Research and Development Program of China (2020YFB0505800, 2020YFB0505804), National Natural Science Foundation of China (42004012), Natural Science Foundation of Shandong Province, China (ZR2020QD048) and by the project RTI2018-094295-B-I00 funded by the MCIN/AEI 1013039/501100011033 which is co-funded by the FEDER program.Peer ReviewedPostprint (published version

The Mechanism for GNSS-Based Kinematic Positioning Degradation at High-Latitudes Under the March 2015 Great Storm

In this study, we focus on the kinematic precise point positioning (PPP) solutions at high-latitudes during the March 2015 great geomagnetic storm. We aim to discover the mechanism behind the positioning degradation from the perspective of the impacts of the storm-induced ionospheric disturbance on the global navigation satellite system (GNSS) data processing. We observed that the phase scintillation dominated the amplitude scintillation at high-latitudes and the variation pattern of the rate of total electron content index (ROTI) was consistent with that of the phase scintillation during the storm. The kinematic PPP errors at high-latitudes were almost three times larger than those at the middle- and low-latitude, which were accompanied by large ROTI variations. From the perspective of GNSS data processing, the large positioning errors were also found to be related to the large number of satellites experiencing cycle slips (CSs). Based on the lock time from the ionospheric scintillation monitoring receiver, we found that a large amount of the CSs was falsely detected under the conventional threshold of the CS detector. By increasing such threshold, the kinematic positioning accuracy at high-latitudes can be improved to obtain similar magnitude as at middle- and low-latitude. The improved positioning accuracy may suggest that the ionospheric disturbance induced by the geomagnetic storm at high-latitudes has minor effects on triggering the CSs. Therefore, precise positioning can be achieved at high-latitudes under geomagnetic storms, given that the CS problem is well addressed.The study is funded by the National Natural Science Foundation of China (No.42004012, 42004025), the Natural Science Foundation of Shandong Province, China (No.ZR2020QD048), the State Key Laboratory of GeoInformation Engineering (No.SKLGIE2019-Z-2-2), the State Key Laboratory of Geodesy and Earth's Dynamics (No. SKLGED-2021-3-4) and by the project RTI2018-094295-B-I00 funded by the MCIN/AEI 10.13039/501100011033, which is co-funded by the FEDER programme.Peer ReviewedPostprint (published version

Evaluation of precipitable water vapor from five reanalysis products with ground-based GNSS observations

At present, the global reliability and accuracy of Precipitable Water Vapor (PWV) from different reanalysis products have not been comprehensively evaluated. In this study, PWV values derived by 268 Global Navigation Satellite Systems (GNSS) stations around the world covering the period from 2016 to 2018 are used to evaluate the accuracies of PWV values from five reanalysis products. The temporal and spatial evolution is not taken into account in this analysis, although the temporal and spatial evolution of atmospheric flows is one of the most important information elements available in numerical weather prediction products. The evaluation results present that five reanalysis products with PWV accuracy from high to low are in the order of the fifth generation of European Centre for Medium-Range Weather Forecasts (ECMWF) Reanalysis (ERA5), ERA-Interim, Japanese 55-year Reanalysis (JRA-55), National Centers for Environmental Prediction/National Center for Atmospheric Research (NCEP/NCAR), and NCEP/DOE (Department of Energy) according to root mean square error (RMSE), bias and correlation coefficient. The ERA5 has the smallest RMSE value of 1.84 mm, while NCEP/NCAR and NCEP/DOE have bigger RMSE values of 3.34 mm and 3.51 mm, respectively. The findings demonstrate that ERA5 and two NCEP reanalysis products have the best and worst performance, respectively, among five reanalysis products. The differences in the accuracy of the five reanalysis products are mainly attributed to the differences in the spatial resolution of reanalysis products. There are some large absolute biases greater than 4 mm between GNSS PWV values and the PWV values of five reanalysis products in the southwest of South America and western China due to the limit of terrains and fewer observations. The accuracies of five reanalysis products are compared in different climatic zones. The results indicate that the absolute accuracies of five reanalysis products are highest in the polar regions and lowest in the tropics. Furthermore, the effects of different seasons on the accuracies of five reanalysis products are also analyzed, which indicates that RMSE values of five reanalysis products in summer and in winter are the largest and the smallest in the temperate regions. Evaluation results from five reanalysis products can help us to learn more about the advantages and disadvantages of the five released water vapor products and promote their applications.Peer ReviewedPostprint (published version

gLAB hands-on education on satellite navigation

The Global Navigation Satellite System (GNSS) allows computing the Position, Velocity and Time (PVT) of users equipped with appropriate hardware (i.e. an antenna and a receiver) and software. The latter estimates the PVT from the ranging measurements and ephemeris transmitted by the GNSS satellites in frequencies of the L band. The research group of Astronomy and Geomatics (gAGE) at the Universitat Politecnica de Catalunya (UPC) has been developing the GNSS LABoratory (gLAB) tool suite since 2009, in the context of the European Space Agency (ESA) educational program on satellite navigation (EDUNAV). gLAB is a multi-purpose software capable of determining the PVT in several modes: stand-alone (e.g. as a smartphone or car navigator), differential (e.g. surveying equipment or precise farming), and augmented with integrity (e.g. civil aviation or safety of life applications). gLAB has been designed for two main sets of users and functions. The first one is to educate University students and professionals in the art and science of GNSS data processing. This includes newcomers to the GNSS field that highly appreciate the Graphical User Interface (GUI), the default templates with the necessary configuration or the messages with warnings and errors. The second group of users are those with previous experience on GNSS. Those are interested into a high computation speed, high-accuracy positioning, batch processing and access to the intermediate computation steps. In the present contribution, we present some examples in which gLAB serves as an education platform. The data sets are actual GNSS measurements collected by the publicly available International GNSS Service (IGS), together with other IGS products such as the satellite orbits and clocks broadcast in the navigation message. The proposed methodology and procedures are tailored to understand the effects of different error components in both the Signal in Space (SIS) and the position domain, by activating or deactivating different modeling terms in gLAB. The results illustrate some examples of how the PVT can be enhanced or deteriorated when using different processing strategies or propagation effects present in the GNSS signals traversing the atmosphere, among others. We conclude that gLAB is a useful tool to learn GNSS data processing or to expand any prior knowledg

Editorial: Rock landslide risk assessment, stability analysis and monitoring for the development of early warning systems and reinforcement measures

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Tourist risk perceptions and revisit intention: A critical review of literature

Tourists’ perceptions of risk with travel destination are one of the key determinants of their decision-making in revisiting a destination. Despite the importance of the subject in tourism literature, a few attempts have been made to focus on the effects of tourist risk perceptions on revisit intentions. Moreover, a theoretical foundation is still lacking in current literature highlighting the relationship of the effect of tourist risk perceptions through satisfaction and attitude towards revisiting with tourist revisit intention. Taking this into account as research gap, this paper provides a critical review of the effect of tourist risk perceptions in tourism research, presenting a descriptive background, identifying the progress, develop an integrated conceptual framework, review of their theoretical propositions and methodological issues and suggesting new areas and approaches for future research. The study concludes that the area is dominated by both the quantitative and the qualitative research, and a lack of appropriate theoretical foundation is a major problem to understand the common risk dimensions and their effect on tourist revisit intention. Therefore, the integration of satisfaction and attitude towards revisit with the relationship between tourist risk perceptions and revisit intention in a single framework seems rational to provide an insight for new research approach

Dimethylarginine metabolism during acute and chronic rejection of rat renal allografts

Background. Dimethylarginines are inhibitors of NO synthesis and are involved in the pathogenesis of vascular diseases. In this study, we ask the question if asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) levels change during fatal and reversible acute rejection, and contribute to the pathogenesis of chronic vasculopathy

Effective risk relievers for dimensional perceived risks on mail-order purchase: a case study on speciality foods in the UK

This article examines the effective risk relievers for different dimensions of perceived risk on mail-order purchase of food products. The sample comprised 1,600 active and inactive mail-order specialty food shoppers in the UK. The analysis focused on the correlation coefficients between consumers' levels of perceived risk and their weight on the importance of the risk relievers. Amongst 15 risk relievers, the results implied that there are certain risk relievers attached to higher levels of importance by consumers, who perceive higher levels of risks in certain aspects of mail-order purchase. Therefore, mail-order companies should promote the effective risk relievers to reduce specific dimensions of perceived risks