Analysis of Enrollment Scale of Chinese Specialty Education

With the adjustment of industrial structure of China in recent years, the market urgently needs different levels of professionals. Specialty education is an important part of higher education in China, has its unique advantages. Through the analysis of the history data of specialty education in our country, the result shows that the specialty education scale has been increasing steadily. However, there are many variables and parameters influencing the enrollment scale. Based on the econometric method, four linear trend prediction models are given and compared. The results show that the accuracy of the simple linear model with lagged data is higher than that of the normal undergraduate enrollment linear model and the model with GDP variable. Keywords: specialty education, enrollment scale, linear mode

Uveal melanoma cells utilize a novel route for transendothelial migration

Uveal melanoma arises in the eye, and it spreads to distant organs in almost half of patients, leading to a fatal outcome. To metastasize, uveal melanoma cells must transmigrate into and out of the microvasculature, crossing the monolayer of endothelial cells that separates the vessel lumen from surrounding tissues. We investigated how human uveal melanoma cells cross the endothelial cell monolayer, using a cultured cell system with primary human endothelial cell monolayers on hydrogel substrates. We found that uveal melanoma cells transmigrate by a novel and unexpected mechanism. Uveal melanoma cells intercalate into the endothelial cell monolayer and flatten out, assuming a shape and geometry similar to those of endothelial cells in the monolayer. After an extended period of time in the intercalated state, the uveal melanoma cells round up and migrate underneath the monolayer. VCAM is present on endothelial cells, and anti-VCAM antibodies slowed the process of intercalation. Depletion of BAP1, a known suppressor of metastasis in patients, increased the amount of transmigration of uveal melanoma cells in transwell assays; but BAP1 depletion did not affect the rate of intercalation, based on movies of living cells. Our results reveal a novel route of transendothelial migration for uveal melanoma cells, and they provide insight into the mechanism by which loss of BAP1 promotes metastasis

Aqueous extract of Aconitum carmichaelii Debeaux attenuates sepsis-induced acute lung injury via regulation of TLR4/NF-ΚB pathway

Purpose: To investigate the therapeutic effect of aqueous extract of Aconitum carmichaelii Debeaux (AEACD) on sepsis-induced acute lung injury (ALI), as well as explore the underlying mechanism of action. Methods: C57BL/6 mice were treated with AEACD by gavage (4.0 g/kg/day) for 5 days before cecal ligation and puncture (CLP) challenge. After 24 h, the pathological morphology of lung tissue and the biochemical parameters in bronchoalveolar lavage fluid (BALF) were determined by H&E staining and enzyme-linked immunosorbent assay (ELISA). Furthermore, the total protein content and lactate dehydrogenase (LDH) level of BALF, as well as the oxidative biomarkers (malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD)) were evaluated in the lung homogenates by ELISA assay. The levels of pro-inflammatory cytokines, TNFα, IL-1β, and IL-6, in lung tissue were measured by qRT-PCR or ELISA. Finally, key proteins in Toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) pathway in lung tissue were evaluated by western blot. Results: CLP challenge induced abnormal changes in the histological structures of lung tissue, lung wet-to-dry weight (W/D) ratio, protein content and LDH levels of BALF, which were remarkably reversed by AEACD. In addition, AEACD decreased MDA levels, and increased GSH levels and SOD activity in the lung tissue of CLP–treated mice (p < 0.05). Furthermore, AEACD attenuated the CLP challengeinduced upregulation of TNFα, IL-1β, and IL-6. Finally, AEACD inactivated TLR4/NF-κB pathway by upregulating IκBα and downregulating TLR4 and phosphorylated-p65 levels. Conclusion: AEACD administration protects mice against sepsis-induced ALI through the regulation of oxidative stress and inflammatory responses in lung tissues. The underlying mechanism occurs by inhibiting TLR4/NF-κB signaling pathway. Keywords: Aconitum carmichaelii Debeaux, Acute lung injury, Sepsis, TLR4, NF-κ

PRIMARY JOURNALS AND THEIR COUNTRIES IN THE FIELD OF DENGUE LITERATURE: AN ANALYSIS

Presents a bibliometric analysis of the literature in the field of Dengue as indexed the MEDLINE data which covered in the Pubmed for the period 2008 to 2017. It is noticed that total of 11826 records on literature of Dengue are covered for a period of ten years from 2008 to 2017. It is also noticed that the maximum number of records (1810) was published during year 2016, followed by 1540 in 2017 and 1520 in 2015. It was found that Journal Article (41.4%), Research Support, Non-U.S. Gov’t (33.81%), Review (10.69%), Letter (3.61%), and Research Support, U.S. Gov\u27t Non-P.H.S. (2.86%). 37 primary journals grouped in zone 1 published 1675 articles accounting for one third of the total output. Similarly the second zone comprises of 143 journals and 904 journals grouped in third zone. Of the 37 titles in zone-1, 12 are associated with United States and followed by England (9), Netherlands (5), India (4), Brazil (2), China (1), Germany (1), Japan (1), Sweden (1) and Thailand (1). In zone-1 & 2 ; out of 180 journals, 51 frequently cited journals are United States, this is followed by the countries i.e. England (33), India (19), Netherlands (11), Brazil (9), Switzerland (9), France (6), Japan (4), China (3), Egypt (3), Germany (3), Pakistan (3), Singapore (3), Colombia (2), Italy (2), Malaysia (2), Thailand (2), Argentina (1), Australia(1), Austria (1), Canada (1), Chile (1), Cuba (1), Indonesia (1), Iran (1), Jamaica (1), Mexico (1), Peru (1), Philippines (1), Poland (1), Sri Lanka (1) and Sweden (1)

Climatic Signals in Wood Property Variables of Picea Crassifolia

Little attention has been given to climatic signals in wood properties. In this study, ring width(RW), annual average microfibril angle (MFA), annual average tracheid radial diameter (TRD), andannual average density (DEN), as the annual and intra-annual wood property variables, were measured at high resolution by SilviScan-3 on dated Picea crassifolia trees. Dendroclimatological methods were used to analyze climatic signals registered in wood property variables. RW, MFA, and TRD negatively correlated with temperature and positively correlated with precipitation in the growing season, whereas the reverse was true for DEN. Climatic signals recorded in the earlywood were similar to those measured for the full width of the annual rings. Climatic signals recorded in latewood were very weak except for latewood MFA. This study showed that wood property variables could be extensive resources for learning more about the influences of climate on tree growth and how trees adapt to ongoing climate change