Dynamic characteristics of aero-engine’s rotor under large maneuvering flight

In view of the large maneuvering overload of the rotor system in Unmanned Aerial Vehicle (UAV), the dynamic characteristics of rotor system under large maneuvering overload conditions were analyzed in this paper. The finite element model of rotor system under large maneuvering overload was first established by Timoshenko beam element theory and finite element method. The motion differential equations of the rotor system were derived by Lagrange equation, and the additional damping matrix, stiffness matrix and excitation force were obtained. Critical speeds and unbalance response were calculated by characteristic equation method and Newmark-β numerical integration method respectively. The calculation results showed that the additional damping and stiffness leaded the critical speeds of the rotor system to change under large maneuvering flight, and the additional excitation force resulted in a certain static displacement of the whirling orbits

Research on the dynamic characteristics of the squeeze film damper of a certain aero-engine

Numerical methods were conducted to simulate the characteristics of SFD under different clearance, eccentricity and precession angular velocity and verified by bidirectional excitation experiments, which is comparatively leading initiative in characteristic measurement of SFD. In addition, finite difference method was introduced to derive Reynolds equation and SOR method to obtain the distribution of oil film, the convergence was also mathematical proof. The results indicate the rotor system keep large vibration state for a long time due to the increasing of actual critical speed of system, which result from the oil film stiffness increases nonlinear excessively with the increase of eccentricity; clearance make a great influence on SFD, especially SFD with large radial size should be kept within 2 ‰

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

SummarySterol regulatory element-binding proteins (SREBPs) are major transcription factors activating the expression of genes involved in biosynthesis of cholesterol, fatty acid and triglyceride. In this study, we identified a small molecule, betulin, that specifically inhibited the maturation of SREBP by inducing interaction of SREBP cleavage activating protein (SCAP) and Insig. Inhibition of SREBP by betulin decreased the biosynthesis of cholesterol and fatty acid. In vivo, betulin ameliorated diet-induced obesity, decreased the lipid contents in serum and tissues, and increased insulin sensitivity. Furthermore, betulin reduced the size and improved the stability of atherosclerotic plaques. Our study demonstrates that inhibition SREBP pathway can be employed as a therapeutic strategy to treat metabolic diseases including type II diabetes and atherosclerosis. Betulin, which is abundant in birch bark, could be a leading compound for development of drugs for hyperlipidemia

Molecular examination of bone marrow stromal cells and chondroitinase ABC-assisted acellular nerve allograft for peripheral nerve regeneration

The present study aimed to evaluate the molecular mechanisms underlying combinatorial bone marrow stromal cell (BMSC) transplantation and chondroitinase ABC (Ch-ABC) therapy in a model of acellular nerve allograft (ANA) repair of the sciatic nerve gap in rats. Sprague Dawley rats (n=24) were used as nerve donors and Wistar rats (n=48) were randomly divided into the following groups: Group I, Dulbecco's modified Eagle's medium (DMEM) control group (ANA treated with DMEM only); Group II, Ch-ABC group (ANA treated with Ch-ABC only); Group III, BMSC group (ANA seeded with BMSCs only); Group IV, Ch-ABC + BMSCs group (Ch-ABC treated ANA then seeded with BMSCs). After 8 weeks, the expression of nerve growth factor, brain-derived neurotrophic factor and vascular endothelial growth factor in the regenerated tissues were detected by reverse transcription-quantitative polymerase chain reaction and immunohistochemistry. Axonal regeneration, motor neuron protection and functional recovery were examined by immunohistochemistry, horseradish peroxidase retrograde neural tracing and electrophysiological and tibialis anterior muscle recovery analyses. It was observed that combination therapy enhances the growth response of the donor nerve locally as well as distally, at the level of the spinal cord motoneuron and the target muscle organ. This phenomenon is likely due to the propagation of retrograde and anterograde transport of growth signals sourced from the graft site. Collectively, growth improvement on the donor nerve, target muscle and motoneuron ultimately contribute to efficacious axonal regeneration and functional recovery. Thorough investigation of molecular peripheral nerve injury combinatorial strategies are required for the optimization of efficacious therapy and full functional recovery following ANA

Enhancement of polar phases in PVDF by forming PVDF/SiC nanowire composite

Different contents of silicon carbide (SiC) nanowires were mixed with Poly(vinylidene fluoride) (PVDF) to facilitate the polar phase crystallization. It was shown that the annealing temperature and SiC content affected on the phase and crystalline structures of PVDF/SiC samples. Furthermore, the addition of SiC nanowire enhanced the transformation of non-polar α phase to polar phases and increased the relative fraction of β phase in PVDF. Due to the nucleating agent mechanism of SiC nanowires, the ion-dipole interaction between the negatively charged surface of SiC nanowires and the positive CH2 groups in PVDF facilitated the formation of polar phases in PVDF

Adaptive Agent Architecture for Real-time Human-Agent Teaming

Teamwork is a set of interrelated reasoning, actions and behaviors of team members that facilitate common objectives. Teamwork theory and experiments have resulted in a set of states and processes for team effectiveness in both human-human and agent-agent teams. However, human-agent teaming is less well studied because it is so new and involves asymmetry in policy and intent not present in human teams. To optimize team performance in human-agent teaming, it is critical that agents infer human intent and adapt their polices for smooth coordination. Most literature in human-agent teaming builds agents referencing a learned human model. Though these agents are guaranteed to perform well with the learned model, they lay heavy assumptions on human policy such as optimality and consistency, which is unlikely in many real-world scenarios. In this paper, we propose a novel adaptive agent architecture in human-model-free setting on a two-player cooperative game, namely Team Space Fortress (TSF). Previous human-human team research have shown complementary policies in TSF game and diversity in human players' skill, which encourages us to relax the assumptions on human policy. Therefore, we discard learning human models from human data, and instead use an adaptation strategy on a pre-trained library of exemplar policies composed of RL algorithms or rule-based methods with minimal assumptions of human behavior. The adaptation strategy relies on a novel similarity metric to infer human policy and then selects the most complementary policy in our library to maximize the team performance. The adaptive agent architecture can be deployed in real-time and generalize to any off-the-shelf static agents. We conducted human-agent experiments to evaluate the proposed adaptive agent framework, and demonstrated the suboptimality, diversity, and adaptability of human policies in human-agent teams.Comment: The first three authors contributed equally. In AAAI 2021 Workshop on Plan, Activity, and Intent Recognitio

New sesquiterpenes from the roots of Ligularia virgaurea

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Study of RNA Interference Targeting NET-1 Combination with Sorafenib for Hepatocellular Carcinoma Therapy In Vitro

The aim of this study is to explore the inhibitory effects of RNA interference (RNAi) targeting NET-1 or combined with sorafenib on HCC in vitro and in vivo and the possible underlying mechanisms. The expressions of NET-1 mRNA and protein were detected by RT-QPCR and western blot. The ability of proliferation was determined by CCK-8 assay. Apoptosis was examined by flow cytometry (FCM). Abilities of migration and invasion were measured by scratch-wound assay and transwell assay. MHCC97H cells with stable transfection of NET-1shRNA were injected subcutaneously to prepare nude mice model of HCC and Caspase-3, Caspase-8, and Caspase-9 mRNAs of tumor tissues in different groups were examined. NET-1 mRNA and protein were reduced sharply in MHCC97H cells transfected with NET-1shRNA. The abilities of proliferation and migration were inhibited and apoptosis was promoted in either NET-1shRNA or sorafenib as compared with untreated cells in vitro and in vivo (P<0.05). The mRNA levels of caspase-3, caspase-8, and caspase-9 of tumor tissues were reduced in different treatment groups compared with untreated group, particularly in combination group. (P<0.05). The combination NET-1shRNA with sorafenib dramatically enhanced the effects of sorafenib antitumor ,which may involve in blocking ras signaling pathway and stimulating apoptotic pathways simultaneously

Ring structure amino acids affect the suppressor activity of melon aphid-borne yellows virus P0 protein

AbstractMelon aphid-borne yellows virus (MABYV) is a newly identified polerovirus occurring in China. Here, we demonstrate that the MABYV encoded P0 (P0MA) protein is a strong suppressor of post-transcriptional gene silencing (PTGS) with activity comparable to tobacco etch virus (TEV) HC-Pro. In addition we have shown that the LP F-box motif present at the N-terminus of P0MA is required for suppressor activity. Detailed mutational analyses on P0MA revealed that changing the conserved Trp 212 with non-ring structured amino acids altered silencing suppressor functions. Ala substitutions at positions 12 and 211 for Phe had no effect on P0 suppression-activity, whereas Arg and Glu substitutions had greatly decreased suppressor activity. Furthermore, substitutions targeting Phe at position 30 also resulted in reduced P0 suppression-activity. Altogether, these results suggest that ring structured Trp/Phe residues in P0 have important roles in suppressor activity