Design and characterization of the readout ASIC for the BESIII CGEM detector

TIGER (Turin Integrated Gem Electronics for Readout) is a mixed-mode ASIC for the readout of signals from CGEM (Cylindrical Gas Electron Multiplier) detector in the upgraded inner tracker of the BESIII experiment, carried out at BEPCII in Beijing. The ASIC includes 64 channels, each of which features a dual-branch architecture optimized for timing and energy measurement. The input signal time-of-arrival and charge measurement is provided by low-power TDCs, based on analogue interpolation techniques, and Wilkinson ADCs, with a fully-digital output. The silicon results of TIGER first prototype are presented showing its full functionality.Peer Reviewe

TIGER: a custom readout electronics for the BESIII CGEM detector

TIGER (aka Torino Integrated Gem Electronics for Readout) is the ASIC designed at INFN-Torino for the front-end electronics of a cylindrical triple GEM detector, proposed to replace the inner tracker of BESIII spectrometer (Beijing Electron Spectrometer). The high luminosity of the collider, operational at the Institute of High Energy Physics in Beijing (IHEP), allows to measure states of charmonium and open charm, to carry out light hadrons spectroscopy and to study $\tau$ lepton physics, but it caused aging and degradation problems to the tracking performance. The 64-channel chip in analog-digital mixed mode has been designed using CMOS 110 nm UMC technology in order to be exported to China. Each channel has two branches: branch E for charge measurements and branch T for time measurements

Distinct Expression Profiles of p63 Variants during Urothelial Development and Bladder Cancer Progression

The TP63 gene, a member of the TP53 tumor suppressor gene family, can be expressed as at least six isoforms due to alternative promoter use and alternative splicing. The lack of p63 isoform–specific antibodies has limited the analysis of the biological significance of p63. We report a novel set of well-defined antibodies to examine p63 isoforms in mouse and human urothelium during embryogenesis and tumor progression, respectively. We provide evidence that basal and intermediate urothelial cells express p63 isoforms, with the TAp63 variant the first to be detected during development, whereas umbrella cells are characterized by a p63-negative phenotype. Notably, we report that p63-null mice develop a bladder with an abnormal urothelium, constituted by a single layer of cells that express uroplakin II and low molecular weight cytokeratins, consistent with an umbrella cell phenotype. Finally, analysis of 202 human bladder carcinomas revealed a new categorization of invasive tumors into basal-like (positive for ΔNp63 and high molecular weight cytokeratins and negative for low molecular weight cytokeratins) versus luminal-like (negative for ΔNp63 and high molecular weight cytokeratins and positive for low molecular weight cytokeratins) phenotypes, with ΔNp63 expression associated with an aggressive clinical course and poor prognosis. This study highlights the relevance of p63 isoforms in both urothelial development and bladder carcinoma progression, with ΔNp63 acting as an oncogene in certain invasive bladder tumors

The new CGEM Inner Tracker and the new TIGER ASIC for the BES III Experiment

A new detector exploiting the technology of Gas Electron Multipliers is under construction to replace the innermost drift chamber of BESIII experiment, since its efficiency is compromised owing the high luminosity of Beijing Electron Positron Collider. The new inner tracker with a cylindrical shape will deploy several new features. The analogue readout and two complementary algorithms to reconstruct the position will allow achieving a spatial resolution of 130 µm in a 1 T magnetic field. For this purpose, TIGER, a new custom 64-channel ASIC, providing time and charge measurements, has been developed. Here, a summary of the most recent results on detector and electronics prototypes is given

Test beam results of a Cylindrical GEM detector for the BESIII experiment

Gas detector are very light instrument used in high energy physics to measure the particle properties: position and momentum. Through high electric field is possible to use the Gas Electron Multiplier (GEM) technology to detect the charged particles and to exploit their properties to construct a large area detector, such as the new IT for BESIII. The state of the art in the GEM production allows to create very large area GEM foils (up to 50x100 $\mathrm{cm}^2$) and thanks to the small thickness of these foils is it possible to shape it to the desired form: a Cylindrical Gas Electron Multiplier (CGEM) is then proposed. The innovative construction technique based on Rohacell, a PMI foam, will give solidity to cathode and anode with a very low impact on material budget. The entire detector is sustained by Permaglass rings glued at the edges. These rings are used to assembly the CGEM, together with a dedicated Vertical Insertion System and moreover they host the On-Detector electronic. The anode has been improved w.r.t. the state of the art through a jagged readout that minimize the inter-strip capacitance. The mechanical challenge of this detector requires a precision of the entire geometry within few hundreds of microns in the whole area. In this contribution an overview of the construction technique, the validation of this technique through the realization of a CGEM, and its first tests will be presented. These activities are performed within the framework of the BESIIICGEM Project (645664), funded by the European Commission in the action H2020-RISE-MSCA-2014.Gas detector are very light instrument used in high energy physics to measure the particle properties: position and momentum.Through high electric field is possible to use the Gas Electron Multiplier (GEM) technology to detect the charged particles and to exploit their properties to construct a large area detector, such as the new IT for BESIII. The state of the art in the GEM production allows to create very large area GEM foils (up to 50x100 $\mathrm{cm}^2$) and thanks to the small thickness of these foils is it possible to shape it to the desired form: a Cylindrical Gas Electron Multiplier (CGEM) is then proposed.The innovative construction technique based on Rohacell, a PMI foam, will give solidity to cathode and anode with a very low impact on material budget. The entire detector is sustained by Permaglass rings glued at the edges. These rings are used to assembly the CGEM, together with a dedicated Vertical Insertion System and moreover they host the On-Detector electronic. The anode has been improved w.r.t. the state of the art through a jagged readout that minimize the inter-strip capacitance.The mechanical challenge of this detector requires a precision of the entire geometry within few hundreds of microns in the whole area.In this contribution an overview of the construction technique, the validation of this technique through the realization of a CGEM, and its first tests will be presented.These activities are performed within the framework of the BESIIICGEM Project (645664), funded by the European Commission in the action H2020-RISE-MSCA-2014