Leading, Knowing and Growing from a Wu Wei Perspective: A Study of Logistics SMEs in Shanghai, China

The aim of the study is to investigate how owner-managers of Chinese SMEs explore and exploit knowledge while growing SMEs in the spirit of Wu Wei. SME growth has been an increasingly important topic, where there is an important link between SME leadership, knowledge and growth. However, a large body of existing research treats knowledge as a static or reified asset or resource such that these studies are mainly concerned with how to create, acquire, transfer or manage knowledge. Following that, the research methods tend to be dominated by quantitative analysis, and weighs towards large organizations in developed economies. Drawing on the data collected in China, this study employs a mixed-methods approach by administering 103 surveys, wherefrom nine owner-managers are isolated for in-depth interviews at three business stages of SMEs (micro, small and medium). By attending to three dimensions (genuine Wu Wei, You Wei and Wu Bu Wei) of a Chinese Daoist Wu Wei perspective, it re-examines the link between SME leadership, knowledge and firm growth. This empirically-derived work shows evidence of subtle changes embedded in the growing process: While owner-managers stress keeping inherent openness to explore knowledge (genuine Wu Wei) and strategically exploit knowledge deployed in their everyday leadership practice (You Wei), growth evolves as a spontaneous and continuous accomplishment (Wu Bu Wei). By adopting a Wu Wei perspective, this study makes distinctive contributions to the understanding of leadership, knowledge and growth, where leadership and knowledge co-evolve and disseminate in the dynamic processes of growing as ‘leadership becoming’ rather than ‘knowledge leadership’. Whilst fostering the co-flow and co-evolution of leading, knowing and growing, the owner-managers undertake the role of knowledge generalist, knowledge supervisor and knowledge mentor within micro, small and medium firms

Using guanxi to conduct elite interviews in China

This is the final version. Available on open access from SAGE Publications via the DOI in this recordDrawing on two research projects in China, this article provides three contributions to the literature on elite interviews. First, we demonstrate how guanxi (informal, particularistic and personal connections) can help to gain access and build trust with Chinese elite interviewees in a dynamic rather than a static way. Second, we show the relational and ongoing process of elite interviewing combining the sensemaking and sensegiving efforts of the interviewer and interviewee. We introduce the concept of sense-becoming to describe how researchers can develop a sense of strategy for future interviews. Third, we highlight the value of guanxi and co-positionality for the interviewer and interviewee to enhance interaction during interviews. We conclude by providing a heuristic for conceptualising the salience of guanxi and sensemaking for elite interviews in China

Impact of enterprise digitalization on green innovation performance under the perspective of production and operation

Introduction: How enterprises should practice digitalization transformation to effectively improve green innovation performance is related to the sustainable development of enterprises and the economy, which is an important issue that needs to be clarified. Methods: This research uses the perspective of production and operation to deconstruct the digitalization of industrial listed enterprises from 2016 to 2020 into six features. A variety of machine learning methods are used, including DBSCAN, CART and other algorithms, to specifically explore the complex impact of enterprise digitalization feature configuration on green innovation performance. Conclusions: (1) The more advanced digitalization transformation the enterprises have, the more possibly the high green innovation performance can be achieved. (2) Digitalization innovation is the digitalization element with the strongest influence ability on green innovation performance. (3) As the advancement of digitalization transformation, enterprises should also focus on digitalization innovation input and digitalization operation output, otherwise they should pay attention to digitalization management and digitalization operation output. Discussion: The conclusions of this research will help enterprises understand their digitalization competitiveness and how to practice digitalization transformation to enhance green innovation performance, and also help the government to formulate policies to promote the development of green innovation in the digital economy era

What happens to refugee-origin entrepreneurs? Combining mixed embeddedness and strategy perspectives in a longitudinal study

Whilst it is acknowledged that refugees are more likely to select into self-employment due to discrimination and labour market exclusion, we know little about how their ventures perform over time. To address this gap, we draw upon qualitative longitudinal evidence gathered in 2010 and 2018 in the UK to explore the outcomes of their ventures and what strategies they have put in place. We argue that the trajectories of refugee-owned businesses are explained by their structural position and the strategies, resources, and business support networks, highlighting that refugee entrepreneurs re-work their condition in a manner that is much more proactive and resilient than suggested by extant portrayals of refugee entrepreneurship. Our analysis sheds new light on the dynamics of refugee business development and encourages a more nuanced theoretical approach to evaluate these enterprises as vehicles for integration against the backdrop of neoliberal Britain

Mucosal and Systemic Immune Responses to Influenza H7N9 Antigen HA1–2 Co-Delivered Intranasally with Flagellin or Polyethyleneimine in Mice and Chickens

Consecutive cases of human infection with H7N9 influenza viruses since 2013 in China have prompted efforts to develop an effective treatment. Subunit vaccines introduced by intranasal administration can block an infection at its primary site; flagellin (fliC) and polyethyleneimine (PEI) have been shown to be potent adjuvants. We previously generated the hemagglutinin (HA)1–2-fliC fusion protein consisting of the globular head domain (HA1–2; amino acids 62–284) of HA fused with Salmonella typhimurium fliC. In the present study, we investigated its effectiveness of both flagellin and PEI as mucosal adjuvants for the H7N9 influenza subunit vaccine. Mice immunized intranasally with HA1–2-fliC and HA1–2-PEI showed higher HA1–2-specific immunoglobulin (Ig)G and IgA titers in serum, nasal wash, and bronchial alveolar lavage fluid. Moreover, splenocyte activation and proliferation and the number of HA1–2-specific interferon (IFN)-γ- and interleukin (IL)-4-producing splenocytes were markedly increased in the fliC and PEI groups; in the latter, there were more cells secreting IL-4 than IFN-γ, suggesting that fliC induced T helper type (Th)1 and Th2 immune responses, and PEI induced Th2-biased responses, consistent with the serum antibody isotype pattern (IgG1/IgG2a ratio). Furthermore, virus challenge was performed in a chicken model. The results showed that chickens receiving fliC and PEI adjuvant vaccine exhibited robust immune responses leading to a significant reduction in viral loads of throat and cloaca compared to chickens receiving only HA1–2. These findings provide a basis for the development of H7N9 influenza HA1–2 mucosal subunit vaccines

Microbial-environmental interactions reveal the evaluation of fermentation time on the nutrient properties of soybean meal

Microbial fermentation techniques are often used to improve their quality, where the keys are fermentation strains and fermentation time. This study studied the interaction between microbiota and environmental (or nutritional) factors and microbiota at different fermentation times to determine the most appropriate time, using lactic acid bacteria as fermentation strains. It can be concluded that fermentation improved the nutritional value of soybean meals. In the early stages of fermentation, debris in soybean meal highly proliferated and destabilized the microbial community, while pH and nutritional conditions played an important role in helping its stabilization. In addition, we must pay attention to the interspecific interactions of microorganisms, which makes it easy to understand how the microbial community maintains community stability. A 4-day fermentation of soybean meal with Lactobacillus is recommended

Profiling analysis of long non-coding RNAs in early postnatal mouse hearts

Mammalian cardiomyocytes undergo a critical hyperplastic-to-hypertrophic growth transition at early postnatal age, which is important in establishing normal physiological function of postnatal hearts. In the current study, we intended to explore the role of long non-coding (lnc) RNAs in this transitional stage. We analyzed lncRNA expression profiles in mouse hearts at postnatal day (P) 1, P7 and P28 via microarray. We identified 1,146 differentially expressed lncRNAs with more than 2.0-fold change when compared the expression profiles of P1 to P7, P1 to P28, and P7 to P28. The neighboring genes of these differentially expressed lncRNAs were mainly involved in DNA replication-associated biological processes. We were particularly interested in one novel cardiac-enriched lncRNA, ENSMUST00000117266, whose expression was dramatically down-regulated from P1 to P28 and was also sensitive to hypoxia, paraquat, and myocardial infarction. Knockdown ENSMUST00000117266 led to a significant increase of neonatal mouse cardiomyocytes in G0/G1 phase and reduction in G2/M phase, suggesting that ENSMUST00000117266 is involved in regulating cardiomyocyte proliferative activity and is likely associated with hyperplastic-to-hypertrophic growth transition. In conclusion, our data have identified a large group of lncRNAs presented in the early postnatal mouse heart. Some of these lncRNAs may have important functions in cardiac hyperplastic-to-hypertrophic growth transition

Dual Antiplatelet Treatment up to 72 Hours after Ischemic Stroke

BackgroundDual antiplatelet treatment has been shown to reduce recurrence of stroke compared to aspirin alone when initiated early after an acute stroke. The effect of clopidogrel and aspirin versus aspirin alone within 72 hours of acute cerebral ischemia from atherosclerosis has not been well studied.MethodsWe conducted a randomized, double-blind, placebo-controlled, 2-by-2 factorial trial in patients with mild ischemic stroke or high-risk transient ischemic attack (TIA) of presumed atherosclerotic cause, not receiving thrombolysis or thrombectomy in 222 hospitals in China. Patients were randomly assigned within 72 hours after symptom onset in a 1:1 ratio, to receive clopidogrel (300mg on day 1, 75mg daily on days 2-90) and aspirin (100-300mg on day1, 100mg daily on days 2-21), or clopidogrel placebo and aspirin (100-300mg on day1, 100mg daily on days 2-90). There was no interaction between this component of the factorial trial design trial and a second part that tested immediate vs delayed stain treatment and is reported separately. The primary efficacy outcome was a new stroke, and the primary safety outcome was moderate-to-severe bleeding, both within 90 days.ResultsA total of 6100 patients were enrolled, 3050 assigned to each trial group. The qualifying event for enrollment was TIA in 13%. Approximately 13% of patients were assigned to a treatment group within 24 hours and 87% were assigned between 24 and 72 hours of onset of stroke. A new stroke occurred in 222 (7.3%) in the clopidogrel-aspirin group, and 279 (9.2%) in the aspirin group (hazard ratio, 0.79; 95% confidence interval [CI], 0.66-0.94; P=0.008). Moderate-to-severe bleeding occurred in 27 (0.9%) and 13 patients (0.4%), respectively (hazard ratio, 2.08; 95% CI, 1.07-4.04, P=0.03).ConclusionsAmong patients with mild ischemic stroke or high-risk TIA of presumed atherosclerotic cause, combined clopidogrel-aspirin initiated within 72 hours of onset was superior to aspirin alone in reducing the risk of new stroke at 90 days but was associated with a low but increased risk of moderate-to-severe bleeding