13,249 research outputs found
Assessment of the potential of MERIS near-infrared water vapour products to correct ASAR interferometric measurements
Atmospheric water vapour is a major limitation for high precision Interferometric Synthetic Aperture Radar (InSAR) applications due to its significant impact on microwave signals. We propose a statistical criterion to test whether an independent water vapour product can reduce water vapour effects on InSAR interferograms, and assess the potential of the Medium Resolution Imaging Spectrometer (MERIS) near-infrared water vapour products for correcting Advanced SAR (ASAR) data. Spatio-temporal comparisons show c. 1.1mm
agreement between MERIS and GPS/radiosonde water vapour products in terms of standard deviations. One major limitation with the use of MERIS water vapour products is the frequency of cloud free conditions. Our analysis indicates that in spite of the low global cloud free conditions (~25%), the frequency can be much higher for certain areas such as Eastern Tibet (~38%) and Southern
California (~48%). This suggests that MERIS water vapour products show potential for correcting ASAR interferometric measurements in certain regions
A comprehensive approach for drug safety assessment
Abstract A comprehensive, multidisciplinary approach is proposed here for the development of a drug with an acceptable safety profile. Key parameters to be considered for drug safety evaluation based on this comprehensive approach include the following: (1) Pharmacology: Possible toxicity due to drug-target interactions, including interactions with unintended molecular targets, or with molecular targets in unintended organs. (2) Chemistry: Chemical scaffolding and side-chains with safety concerns. (3) Toxicology: Toxicity in animals in vivo, and in relevant animal and human cells in culture. (4) Drug metabolism and pharmacokinetics: Safety concerns due to toxification or detoxification, organ distribution, clearance and pharmacokinetic drug-drug interactions. (5) Risk factors: Physiological, environmental and genetic factors that may enhance a patient's susceptibility. It is proposed that this integrated, multidisciplinary approach to safety evaluation may enhance the accuracy of the prediction of drug safety and thereby the efficiency of drug development
Drinfeld Twists and Symmetric Bethe Vectors of Supersymmetric Fermion Models
We construct the Drinfeld twists (factorizing -matrices) of the
-invariant fermion model. Completely symmetric representation of the
pseudo-particle creation operators of the model are obtained in the basis
provided by the -matrix (the -basis). We resolve the hierarchy of the
nested Bethe vectors in the -basis for the supersymmetric model.Comment: Latex File, 24 pages, no figure, some misprints are correcte
GALEX, Optical and IR Light Curves of MQ Dra: UV Excesses at Low Accretion Rates
Ultraviolet light curves constructed from NUV and FUV detectors on GALEX
reveal large amplitude variations during the orbital period of the Low
Accretion Rate Polar MQ Dra (SDSSJ1553+55). This unexpected variation from a UV
source is similar to that seen and discussed in the Polar EF Eri during its low
state of accretion, even though the accretion rate in MQ Dra is an order of
magnitude lower than even the low state of EF Eri. The similarity in phasing of
the UV and optical light curves in MQ Dra imply a similar location for the
source of light. We explore the possibilities of hot spots and cyclotron
emission with simple models fit to the UV, optical and IR light curves of MQ
Dra. To match the GALEX light curves with a single temperature circular hot
spot requires different sizes of spots for the NUV and FUV, while a cyclotron
model that can produce the optical harmonics with a magnetic field near 60 MG
requires multipoles with fields > 200 MG to match the UV fluxes.Comment: accepted for ApJ; 15 pages, 7 tables, 8 fig
Network Topology of an Experimental Futures Exchange
Many systems of different nature exhibit scale free behaviors. Economic
systems with power law distribution in the wealth is one of the examples. To
better understand the working behind the complexity, we undertook an empirical
study measuring the interactions between market participants. A Web server was
setup to administer the exchange of futures contracts whose liquidation prices
were coupled to event outcomes. After free registration, participants started
trading to compete for the money prizes upon maturity of the futures contracts
at the end of the experiment. The evolving `cash' flow network was
reconstructed from the transactions between players. We show that the network
topology is hierarchical, disassortative and scale-free with a power law
exponent of 1.02+-0.09 in the degree distribution. The small-world property
emerged early in the experiment while the number of participants was still
small. We also show power law distributions of the net incomes and
inter-transaction time intervals. Big winners and losers are associated with
high degree, high betweenness centrality, low clustering coefficient and low
degree-correlation. We identify communities in the network as groups of the
like-minded. The distribution of the community sizes is shown to be power-law
distributed with an exponent of 1.19+-0.16.Comment: 6 pages, 12 figure
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