The geometric realization of a simplicial Hausdorff space is Hausdorff

It is shown that the thin geometric realization of a simplicial Hausdorff space is Hausdorff. This proves a famous claim by Graeme Segal that the thin geometric realisation of a simplicial k-space is a k-space.Comment: 19 page

The temporary labor force

Labor market ; Temporary employees

Wage differentials for temporary services work: evidence from administrative data

We use administrative data from the unemployment insurance system State of Washington to study the magnitude of the wage differential associated with work in the temporary services industry. We find that temp wage rates are 15% to 20% below the levels that might have been expected based on trends during other periods in workers' careers even after controlling for differences between temps and other workers. Comparing temp wages immediately before and after temp work or to the wages on non-temp jobs begun during the same period as workers were in the temp industry yields estimates of the temp work penalty as low as 10%.Wages ; Temporary employees

Black/white differences in wealth

This article studies the extent to which the wide gap in the wealth holdings of whites and African Americans can be explained by differences in family income and demographic characteristics.Wealth ; Income ; Demography

Dynamics and Lax-Phillips scattering for generalized Lamb models

This paper treats the dynamics and scattering of a model of coupled oscillating systems, a finite dimensional one and a wave field on the half line. The coupling is realized producing the family of selfadjoint extensions of the suitably restricted self-adjoint operator describing the uncoupled dynamics. The spectral theory of the family is studied and the associated quadratic forms constructed. The dynamics turns out to be Hamiltonian and the Hamiltonian is described, including the case in which the finite dimensional systems comprises nonlinear oscillators; in this case the dynamics is shown to exist as well. In the linear case the system is equivalent, on a dense subspace, to a wave equation on the half line with higher order boundary conditions, described by a differential polynomial $p(\partial_x)$ explicitely related to the model parameters. In terms of such structure the Lax-Phillips scattering of the system is studied. In particular we determine the incoming and outgoing translation representations, the scattering operator, which turns out to be unitarily equivalent to the multiplication operator given by the rational function $-p(i\kappa)^*/p(i\kappa)$, and the Lax-Phillips semigroup, which describes the evolution of the states which are neither incoming in the past nor outgoing in the future

Small Sample Bias in GMM Estimation of Covariance Structures

We examine the small sample properties of the GMM estimator for models of covariance structures, where the technique is often referred to as the optimal minimum distance (OMD) estimator. We present a variety of Monte Carlo experiments based on simulated data and on the data used by Abowd and Card (1987, 1990) in an examination of the covariance structure of hours and earnings changes. Our main finding is that OMD is seriously biased in small samples for many distributions and in relatively large samples for poorly behaved distributions. The bias is almost always downward in absolute value. It arises because sampling errors in the second moments are correlated with sampling errors in the weighting matrix used by OMD. Furthermore, OMD usually has a larger root mean square error and median absolute error than equally weighted minimum distance (EWMD). We also propose and investigate an alternative estimator, which we call independently weighted optimal minimum distance (IWOMD). IWOMD is a split sample estimator using separate groups of observations to estimate the moments and the weights. IWOMD has identical large sample properties to the OMD estimator but is unbiased regardless of sample size. However, the Monte Carlo evidence indicates that IWOMD is usually dominated by EWMD.

A Smooth Model for the String Group

We construct a model for the string group as an infinite-dimensional Lie group. In a second step we extend this model by a contractible Lie group to a Lie 2-group model. To this end we need to establish some facts on the homotopy theory of Lie 2-groups. Moreover, we provide an explicit comparison of string structures for the two models and a uniqueness result for Lie 2-group models.Comment: 32 pages; v2: uniqueness result for 2-group models added (Th. 6.5), typo in title corrected; v3: construction of basic PU(H)-bundle discussed (Rem. 3.9), final version to appear in IMR

Incorporating expression data in metabolic modeling: a case study of lactate dehydrogenase

Integrating biological information from different sources to understand cellular processes is an important problem in systems biology. We use data from mRNA expression arrays and chemical kinetics to formulate a metabolic model relevant to K562 erythroleukemia cells. MAP kinase pathway activation alters the expression of metabolic enzymes in K562 cells. Our array data show changes in expression of lactate dehydrogenase (LDH) isoforms after treatment with phorbol 12-myristate 13-acetate (PMA), which activates MAP kinase signaling. We model the change in lactate production which occurs when the MAP kinase pathway is activated, using a non-equilibrium, chemical-kinetic model of homolactic fermentation. In particular, we examine the role of LDH isoforms, which catalyze the conversion of pyruvate to lactate. Changes in the isoform ratio are not the primary determinant of the production of lactate. Rather, the total concentration of LDH controls the lactate concentration.Comment: In press, Journal of Theoretical Biology. 27 pages, 9 figure

Examining sex differences in knee pain: the Multicenter Osteoarthritis Study

SummaryObjectiveTo determine whether women experience greater knee pain severity than men at equivalent levels of radiographic knee osteoarthritis (OA).Design and methodsA cross-sectional analysis of 2712 individuals (60% women) without knee replacement or a recent steroid injection. Sex differences in pain severity at each Kellgren–Lawrence (KL) grade were assessed by knee using visual analog scale (VAS) scale and Western Ontario and McMaster Universities Arthritis Index (WOMAC) with and without adjustment for age, analgesic use, Body mass index (BMI), clinic site, comorbid conditions, depression score, education, race, and widespread pain (WSP) using generalized estimating equations. Effect sizes (Cohen's d) were also calculated. Analyses were repeated in those with and without patellofemoral OA (PFOA).ResultsWomen reported higher VAS pain at all KL grades in unadjusted analyses (d = 0.21–0.31, P < 0.0001–0.0038) and in analyses adjusted for all covariates except WSP (d = 0.16–0.22, P < 0.0001–0.0472). Pain severity differences further decreased with adjustment for WSP (d = 0.10–0.18) and were significant for KL grade ≤2 (P = 0.0015) and 2 (P = 0.0200). Presence compared with absence of WSP was associated with significantly greater knee pain at all KL grades (d = 0.32–0.52, P < 0.0001–0.0008). In knees with PFOA, VAS pain severity sex differences were greater at each KL grade (d = 0.45–0.62, P = 0.0006–0.0030) and remained significant for all KL grades in adjusted analyses (d = 0.31–0.57, P = 0.0013–0.0361). Results using WOMAC were similar.ConclusionsWomen reported greater knee pain than men regardless of KL grade, though effect sizes were generally small. These differences increased in the presence of PFOA. The strong contribution of WSP to sex differences in knee pain suggests that central sensitivity plays a role in these differences