Elastic precursor of the transformation from glycolipid-nanotube to -vesicle

By the combination of optical tweezer manipulation and digital video microscopy, the flexural rigidity of single glycolipid "nano" tubes has been measured below the transition temperature at which the lipid tubules are transformed into vesicles. Consequently, we have found a clear reduction of the rigidity obviously before the transition as temperature increasing. Further experiments of infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC) have suggested a microscopic change of the tube walls, synchronizing with the precursory softening of the nanotubes.Comment: 9 pages, 6 figure

Pattern formation by lateral inhibition with feedback: a mathematical model of Delta-Notch intercellular signalling

In many developing tissues, adjacent cells diverge in character so as to create a fine-grained pattern of cells in contrasting states of differentiation. It has been proposed that such patterns can be generated through lateral inhibition—a type cells–cell interaction whereby a cell that adopts a particular fate inhibits its immediate neighbours from doing likewise. Lateral inhibition is well documented in flies, worms and vertebrates. In all of these organisms, the transmembrane proteins Notch and Delta (or their homologues) have been identified as mediators of the interaction—Notch as receptor, Delta as its ligand on adjacent cells. However, it is not clear under precisely what conditions the Delta-Notch mechanism of lateral inhibition can generate the observed types of pattern, or indeed whether this mechanism is capable of generating such patterns by itself. Here we construct and analyse a simple and general mathematical model of such contact-mediated lateral inhibition. In accordance with experimental data, the model postulates that receipt of inhibition (i.e. activation of Notch) diminishes the ability to deliver inhibition (i.e. to produce active Delta). This gives rise to a feedback loop that can amplify differences between adjacent cells. We investigate the pattern-forming potential and temporal behavior of this model both analytically and through numerical simulation. Inhomogeneities are self-amplifying and develop without need of any other machinery, provided the feedback is sufficiently strong. For a wide range of initial and boundary conditions, the model generates fine-grained patterns similar to those observed in living systems

S and P-wave heavy-light mesons in lattice NRQCD

The mass spectrum of S and P-wave mesons containing a single heavy quark is computed in the quenched approximation, using NRQCD up to third order in the inverse heavy quark mass expansion. Previous results found third order contributions which are as large in magnitude as the total second order contribution for the charmed S-wave spin splitting. The present work considers variations such as anisotropic lattices, Landau link tadpole improvement, and a highly-improved light quark action, and finds that the second order correction to the charmed S-wave spin splitting is about 20% of the leading order contribution, while the third order correction is about 20%(10%) for D^*-D(D_s^*-D_s). Nonleading corrections are very small for the bottom meson spectrum, and are statistically insignificant for the P-wave charmed masses. The relative orderings among P-wave charmed and bottom mesons, and the sizes of the mass splittings, are discussed in light of experimental data and existing calculations.Comment: 21 pages including 6 figures, changed method of fitting correlators, this version to be published in Phys Rev

Attractive instability of oppositely charged membranes induced by charge density fluctuations

We predict the conditions under which two oppositely charged membranes show a dynamic, attractive instability. Two layers with unequal charges of opposite sign can repel or be stable when in close proximity. However, dynamic charge density fluctuations can induce an attractive instability and thus facilitate fusion. We predict the dominant instability modes and timescales and show how these are controlled by the relative charge and membrane viscosities. These dynamic instabilities may be the precursors of membrane fusion in systems where artificial vesicles are engulfed by biological cells of opposite charge

Mathematical Analysis and Simulations of the Neural Circuit for Locomotion in Lamprey

We analyze the dynamics of the neural circuit of the lamprey central pattern generator (CPG). This analysis provides insights into how neural interactions form oscillators and enable spontaneous oscillations in a network of damped oscillators, which were not apparent in previous simulations or abstract phase oscillator models. We also show how the different behaviour regimes (characterized by phase and amplitude relationships between oscillators) of forward/backward swimming, and turning, can be controlled using the neural connection strengths and external inputs.Comment: 4 pages, accepted for publication in Physical Review Letter

Geometric Phases, Symmetries of Dynamical Invariants, and Exact Solution of the Schr\"odinger Equation

We introduce the notion of the geometrically equivalent quantum systems (GEQS) as quantum systems that lead to the same geometric phases for a given complete set of initial state vectors. We give a characterization of the GEQS. These systems have a common dynamical invariant, and their Hamiltonians and evolution operators are related by symmetry transformations of the invariant. If the invariant is $T$-periodic, the corresponding class of GEQS includes a system with a $T$-periodic Hamiltonian. We apply our general results to study the classes of GEQS that include a system with a cranked Hamiltonian $H(t)=e^{-iKt}H_0e^{iKt}$. We show that the cranking operator $K$ also belongs to this class. Hence, in spite of the fact that it is time-independent, it leads to nontrivial cyclic evolutions and geometric phases. Our analysis allows for an explicit construction of a complete set of nonstationary cyclic states of any time-independent simple harmonic oscillator. The period of these cyclic states is half the characteristic period of the oscillator.Comment: Accepted for publication in J. Phys.

Newton-Hooke spacetimes, Hpp-waves and the cosmological constant

We show explicitly how the Newton-Hooke groups act as symmetries of the equations of motion of non-relativistic cosmological models with a cosmological constant. We give the action on the associated non-relativistic spacetimes and show how these may be obtained from a null reduction of 5-dimensional homogeneous pp-wave Lorentzian spacetimes. This allows us to realize the Newton-Hooke groups and their Bargmann type central extensions as subgroups of the isometry groups of the pp-wave spacetimes. The extended Schrodinger type conformal group is identified and its action on the equations of motion given. The non-relativistic conformal symmetries also have applications to time-dependent harmonic oscillators. Finally we comment on a possible application to Gao's generalization of the matrix model.Comment: 21 page

Dynamics of electrons in the quantum Hall bubble phases

In Landau levels N > 1, the ground state of the two-dimensional electron gas (2DEG) in a perpendicular magnetic field evolves from a Wigner crystal for small filling of the partially filled Landau level, into a succession of bubble states with increasing number of guiding centers per bubble as the filling increases, to a modulated stripe state near half filling. In this work, we show that these first-order phase transitions between the bubble states lead to measurable discontinuities in several physical quantities such as the density of states and the magnetization of the 2DEG. We discuss in detail the behavior of the collective excitations of the bubble states and show that their spectra have higher-energy modes besides the pinned phonon mode. The frequencies of these modes, at small wavevector k, have a discontinuous evolution as a function of filling factor that should be measurable in, for example, microwave absorption experiments.Comment: 13 pages, 7 figures. Corrected typos in eqs. (38),(39),(40