Diet in the prevention and treatment of depression - systematic review

Depression is one of the leading causes of disability worldwide. It affects, according to WHO, nearly 300 million people worldwide, a number close to 3,8 % of the world’s population. Depression is not exclusively a mental disorder limited to psychiatry, nowadays it is present in all medical fields. It has a significant association with many comorbidities, as an example cardiovascular diseases and metabolic disorders. Additionally, depression often is manifested with psychosomatic symptoms. Both aspects lead clinicians to major diagnostic and therapeutic challenges. Each one of dietary element: omega-3 fatty acids, zinc, selenium, iron, vitamin B12, vitamin D, folate, creatine was found to correspond with mental health in patients and the level of mentioned diet components is negatively correlated with depression risk of individuals. Each of the dietary aspect considered in the article has a significant correlation with depression disorder and might support the new multidisciplinary attitude toward it in mental health.&nbsp

Zagrożenia zdrowotne wśród dzieci i młodzieży. T. 3

Praca recenzowana / Peer-reviewed pape

Geological structure of the Krasnobród area, Roztocze.

Krasnobród geograficznie położony jest w dolinie rzeki Wieprz na terenie Roztocza Środkowego, które jest częścią Wyżyny Lubelskiej, a geologicznie w obrębie zachodniej części Platformy Wschodnioeuropejskiej w pobliskim sąsiedztwie strefy T-T. Najstarszymi skałami, które odsłaniają się na tym obszarze są skały kredowe wieku mastrycht dolny: gezy, budujące wzgórza położone na południe od rzeki, oraz opoki i opoki margliste, budujące wzgórza na północ od rzeki i odsłaniające się w miejscowym ,,Kamieniołomie’’. Innymi utworami są holoceńskie osady aluwialne, deluwialne, piaski humusowe, torfy (borowina) i namuły torfiaste, a także plejstoceńskie lessy oraz piaski eoliczne. W Krasnobrodzie na szczególną uwagę zasługuje stanowisko dokumentacyjne ,,Kamieniołom’’, które jest częścią Szlaku geoturystycznego Roztocza Środkowego. Okazy paleontologiczne reprezentujące mastrychcką makrofaunę morską zostały zebrane w kamieniołomie i umieszczone w Muzeum Geologicznym przy kościele parafialnym NNMP w Krasnobrodzie. Z kamieniołomu pobrano 3 próbki w celu wstępnego zbadania mikrofauny. W badanym materiale stwierdzono przewagę otwornic bentonicznych. Otwornicą bentoniczną przewodnią dla mastrychtu dolnego jest Angulogavelinella gracilis.Krasnobród is geographically situated in the valley of the Wieprz river in the Central Roztocze, which is part of the Lublin Upland. It is geologically located within the western part of the Eastern Europe Platform in the nearby vicinity of the T-T zone. The oldest rocks which outcrop in this area are the Cretaceous-lower Maastrichtian age rocks: gaizes, which build the hills located to the south of the river, and opokas and marl opokas, which build the hills located to the north of the river and reveal in the local stone quarry ,,Kamieniołom''. Other formations are Holocene alluvial and deluvial deposits, humus sands, peat (therapeutic mud) and peat silts, as well as Pleistocene loess and aeolian sands. In Krasnobród on a special attention deserves a documentation quarry ,,Kamieniołom’', which is part of the Geotouristic trail of the Central Roztocze. Paleontological specimens representing Maastrichtian marine macrofauna were collected in the quarry and placed in the Geological Museum at the parish church of Our Lady in Krasnobród. There had been collected 3 samples from the quarry in order to microfauna initial study. The analyzed material showed dominance of the benthic foraminifera. Index benthic microfossil for lower Maastrichtian is Angulogavelinella gracilis

Frontex Agency against current migration crisis

Agencja Frontex swoje działania opiera na wywiadzie, analizie oraz na przewidywaniu i szacowaniu zdarzeń, które wpływają na bezpieczeństw granic państw członkowskich Unii Europejskiej. Zarządzanie zewnętrznymi granicami Unii Europejskiej przez Agencję Frontex stanowi jeden z ważniejszych tematów w zakresie polityki bezpieczeństwa na terenie Europy. Działania Agencji wpływają na poprawę ochrony i kontrolowania granic zewnętrznych państw członkowskich przed masowym napływem obywateli pochodzących z państw trzecich. Poziom życia, ustrój polityczny oraz ochrona i poszanowanie praw człowieka w Europie stanowią główne czynniki, które przyciągają uchodźców. Niejednokrotnie działania Frontexu udowodniły jaką ważną rolę odgrywa Agencja. Przykładem oczywiście jest obecny kryzys migracyjny. Frontex dokonuje wszelkich starań aby wzmocnić ochronę i kontrolę granic, ponadto podjął ogromne wyzwanie - opieki nad imigrantami, którzy przedostali się na teren Unii Europejskiej.Frontex actions are based on an interview, analysis and predicting and assessing events that affect the safety limits of the Member States of the European Union. Management of external borders of the European Union by Frontex is one of the most important topics in the field of security policy in Europe. The Agency's activities to improve the protection and control of the external borders of the Member States before the massive influx of citizens from third countries. The level of life, politics and the protection of and respect for human rights in Europe are the main factors that attract the refugees. Often the activities of Frontex has demonstrated that the Agency plays an important role. An example of course is the current refugee crisis. Frontex makes every effort to strengthen the protection and control of the borders, also has taken a huge challenge-care of the immigrants, who infiltrated into the European Union

Biodegradable Chitosan Decreases the Immune Response to Trichinella spiralis in Mice

The purpose of this study was to evaluate the potential of chitosan units released during natural degradation of the polymer to activate the immune system against T. spiralis infection. High molecular weight chitosan was injected intraperitoneally into C57BL/6 mice. Flow cytometry and cytokine concentration, measured by ELISA, were used to characterize peritoneal cell populations during T. spiralis infection. The strong chemo-attractive properties of chitosan caused considerable infiltration into the peritoneal cavity of CD11b+ cells, with reduced expression of MHC class II, CD80, CD86, Dectin-1 or CD23 receptors in comparison to T. spiralis-infected mice. After prolonged chitosan biodegradation, cell populations expressing IL-4R, MR and Dectin-1 receptors were found to coexist with elevated IL-6, IL-10, TGF-β and IgA production. IgA cross-reacted with T. spiralis antigen and chitosan. It was found that chitosan treatment attracted immune cells with low activity, which resulted in the number of nematodes increasing. The glucosamine and N-acetyl-D-glucosamine residues were recognized by wheat germ agglutinin (WGA) lectin and therefore any biodegradable chitosan units may actively downregulate the immune response to the parasite. The findings are relevant for both people and animals treated with chitosan preparations

A Unique Glassy Cell Carcinoma (GCC) of the Cervix Diagnosed during Pregnancy—A Case Report

Glassy Cell carcinoma (GCC) of the cervix is classified as a unique, aggressive neoplasm, with different sensitivity to chemotherapy and radiotherapy. It is such an extremely rare tumor that it is practically not observed during pregnancy. Information on the coexistence of cervical GCC with pregnancy is also unique, so it seems extremely important to disseminate it in order to develop the most effective treatment regimen. Additionally, making any decisions regarding therapeutic methods during pregnancy encounters great ethical problems. We present the case of a 26-year-old pregnant woman, 18 weeks gestation, diagnosed with GCC of the cervix, IB3 grade in the International Federation of Gynecology and Obstetrics (FIGO) scale. Despite the unfavorable prognosis, the use of chemotherapy in a pregnant patient brought on a favorable therapeutic effect, without any negative effects on the fetus. The article also presents a literature review on the epidemiology, pathology, immunohistochemistry, treatment and prognosis of this rare disease

HPV Vaccination among Polish Adolescents-Results from POLKA 18 Study.

Human Papillomavirus (HPV) is the main cause of cervical cancer and genital warts and constitutes one of the most common sexually transmitted infections. Cervical cancer is the only reproductive cancer that has a primary prevention programme through the introduction of HPV vaccinations. Even though the majority of European countries have nationally funded HPV vaccination programmes, in Poland these are exclusively local and scarcely funded. Moreover, the majority of local programmes are directed to females only. Meanwhile, Poland has one of the highest cervical cancer incidence rates among high income countries. The aim of this study was to measure HPV vaccination levels among final-year students in Poland and to establish the association between vaccination status and gender, region and level of sexual education received. This study is a part of the POLKA 18 Study, which used original self-reported paper-based questionnaires distributed in schools in six Polish regions. The study was conducted between April and December 2019. The obtained data were analysed in STATA 17. In total, 2701 fully completed questionnaires were collected. Over half of the respondents (58.2%) did not know their HPV vaccination status. Only 16.0% of the respondents replied that they have been vaccinated against HPV (18.2% of females and 14.5% of males). There was no direct association between vaccination status and access to ‘family life education’ classes. The vaccination level significantly differed among the different regions of Poland (p < 0.0001), with the Śląskie and Wielkopolskie regions achieving the highest rates. At least a quarter of adolescents after their sexual debut have not been vaccinated against HPV. Regions with immunization programmes introduced to their provincial capitals had higher vaccination rates. Our findings indicate the need for the introduction of state-funded vaccination programmes at the national level for the vaccination rate to increase, which will have the potential to decrease cervical cancer incidence in the country

Abdominoplasty Skin-Based Dressing for Deep Wound Treatment&mdash;Evaluation of Different Methods of Preparation on Therapeutic Potential

The management of hard-to-heal wounds is a significant clinical challenge. Acellular dermal matrices (ADMs) have been successfully introduced to enhance the healing process. Here, we aimed to develop protocol for the preparation of novel ADMs from abdominoplasty skin. We used three different decellularization protocols for skin processing, namely, 1M NaCl and sodium dodecyl sulfate (SDS, in ADM1); 2M NaCl and sodium dodecyl sulfate (SDS, in ADM1); and a combination of recombinant trypsin and Triton X-100 (in hADM 3). We assessed the effectiveness of decellularization and ADM&rsquo;s structure by using histochemical and immunochemical staining. In addition, we evaluated the therapeutic potential of novel ADMs in a murine model of wound healing. Furthermore, targeted transcriptomic profiling of genes associated with wound healing was performed. First, we found that all three proposed methods of decellularization effectively removed cellular components from abdominoplasty skin. We showed, however, significant differences in the presence of class I human leukocyte antigen (HLA class I ABC), Talin 1/2, and chondroitin sulfate proteoglycan (NG2). In addition, we found that protocols, when utilized differentially, influenced the preservation of types I, III, IV, and VII collagens. Finally, we showed that abdominoplasty skin-derived ADMs might serve as an effective and safe option for deep wound treatment. More importantly, our novel dressing (ADM1) improves the kinetics of wound closure and scar maturation in the proliferative and remodeling phases of wound healing. In conclusion, we developed a protocol for abdominoplasty skin decellularization suitable for the preparation of biological dressings. We showed that different decellularization methods affect the purity, structure, and therapeutic properties of ADMs