2006 Lowbush Blueberry Project Reports

The 2006 edition of the Lowbush Blueberry Project Reports was prepared for the Wild Blueberry Commission of Maine and the Wild Blueberry Advisory Committee by researchers at the University of Maine, Orono. Projects in this report include: 1. Evaluation of Emerging Disinfection Technologies for Wild Blueberry Processing 2. Incorporation of wild blueberry puree into a soy-based burger and its effect on sensory and chemical properties of the broiled burgers 3. Infestation Detection using NIRS 4. Mechanism of Action through which Wild Blueberries affect Arterial Functional Properties in Normotensive and Spontaneously Hypertensive Rats 5. Practical Microbial Control Approach for Wild Blueberries and their Antimicrobial Property 6. Wild Blueberry Consumption and Risks for Cardiovascular Disease 7. Irrigation Water use in Wild Blueberry Production 8. Control Tactics for Blueberry Pest Insects & Program Base 9. Integrated Pest Management (IPM) Strategies 10. Biology and Ecology of Blueberry Insect Pests, 2006 11. Research on Wild Blueberry Diseases for 2006-2007 12. Effect of Soil pH on Nutrient Uptake 13. Effect of Manganese on Growth and Yield of Wild Blueberry 14. Effects of Summer Foliar Fertilization to Increase Branch Length and Flower Bud Formation in the Prune Year 15. Effects of Phosphite Foliar Fertilizers on disease control and fruit set of wild blueberry 16. Assessment of Hexazinone Alternatives for Weed Control in Wild Blueberries 17. Evaluation of Fall Applications of Tribenuron Methyl for Bunchberry Control in Wild Blueberries 18. Evaluation of spot treatments of Tribenuron Methyl, Ultim and Roundup for weed control in Wild Blueberries 19. Blueberry Extension Education Program 20. Cultural Weed Management Using p

2014 Wild Blueberry Project Reports

FOOD SCIENCE AND NUTRITION PAGE 1. Development of effective intervention measures to maintain and improve food safety for wild blueberries 2. Role of wild blueberries on lipid metabolism and inflammation as related to obesity and the Metabolic Syndrome ENTOMOLOGY 3. Control tactics for blueberry pest insects, 2014 4. Pest biology and IPM, 2014 5. Biology of spotted wing drosophila, 2014 6. Biology of blueberry, beneficial insects, and blueberry pollination DISEASE MANAGEMENT 7. Research and control of mummy berry disease 8. Evaluation of fungicides for control of mummy berry on lowbush blueberry (2014) WEED MANAGEMENT 9. A 2014 preliminary trial for a Callisto-Matrix tank mix versus a traditional wild blueberry herbicide spray regimen EXTENSION 10. Wild blueberry Extension Education Program in 2014 INPUT SYSTEMS STUDY – SCRI GRANT 11. Systems approach to improving the sustainability of wild blueberry production, Year Five of a six-year study – experimental design 12. Food safety- Prevalence study of Escherichia coli O157:H7, Listeria monocytogenes and Salmonella spp. on lowbush blueberries (Vaccinium angustifolium) 13. Systems approach to improving the sustainability of wild blueberry production, Year 5 – reports from Frank Drummond 14. Systems approach to improving the sustainability of wild blueberry production, 2014, Year 5 of a six-year study, disease management results 15. Systems approach to improving the sustainability of wild blueberry production, Year Five of a six-year study, weed management results 16. Systems approach to improving the sustainability of wild blueberry production, Year Five of a six year study, plant productivity 17. 2014 economic analysis of Maine blueberry production systems including an introductory risk analysis 18. Biosensor development for food safety (ancillary study) 19. Ancillary projects in disease research (ancillary study) 20. Systems approach to improving the sustainability of wild blueberry production – Ancillary land-leveling study, Year Four of a four-year study (ancillary study) 21. 2013-14 evaluation of three pre-emergence herbicides alone and in combination with Velpar or Sinbar for effects on wild blueberry productivity and weed control – 2014 crop year results (ancillary study) 22. Evaluation of fall and spring combinations of preemergence herbicides to prevent weed resistance in wild blueberry fields, 2013-15 (ancillary study) 23. Post-harvest control of red sorrel in a non-crop blueberry field, 2012-2014 (ancillary study) 24. Post-harvest control of red sorrel in a non-crop blueberry field, 2013-2015 (ancillary study) 25. Effect of soil nutrient amendments on growth and yield of wild blueberries in Maine (ancillary study

2015 Wild Blueberry Project Reports

FOOD SCIENCE AND NUTRITION 1. Increasing the food safety margin of wild blueberries through improved intervention measures ENTOMOLOGY 2. Control tactics for blueberry pest insects, 2015 3. Pest biology and IPM, 2015 4. Biology of spotted wing drosophila, 2015 5. Biology of blueberry bees, and blueberry pollination DISEASE MANAGEMENT 6. Research and control of mummy berry disease 7. Evaluation of fungicides for control of mummy berry on lowbush blueberry (2015) 8. Evaluation of fungicides for control of leafspot on lowbush blueberry (2015) WEED MANAGEMENT 9. Single vs split applications of post-emergent herbicides for spreading dogbane (Apocynum androsaemifolium) control in wild blueberry fields 10. Evaluation of fall applications of herbicides targeting horseweed in wild blueberry fields 11. Herbicide combinations with Sinbar and Grounded to assess efficacy on weed control in wild blueberry EXTENSION 12. Wild Blueberry Extension Education Program in 2015 INPUT SYSTEMS STUDY – SCRI GRANT PAGE 13. Systems approach to improving the sustainability of wild blueberry production, Year Six of a six-year study – experimental design 14. Systems approach to improving the sustainability of wild blueberry production, Year 6 15. Systems approach to improving the sustainability of wild blueberry production, 2015, Year 6 of a six-year study, disease management results 16. Systems approach to improving the sustainability of wild blueberry production, Year Six of a six-year study, weed management results 17. Systems approach to improving the sustainability of wild blueberry production, preliminary economic comparison for 2014-15 18. Ancillary projects in disease research (ancillary study) 19. Evaluation of fall and spring combinations of preemergence herbicides to prevent weed resistance in wild blueberry fields, 2013-15 (ancillary study) 20. Post-harvest control of red sorrel in a non-crop blueberry field, 2013-2015 - crop year evaluation (ancillary study) 21. Evaluation of spring applications of herbicides targeting red sorrel in wild blueberry fields (ancillary study

2013 Wild Blueberry Project Reports

The 2013 edition of the Wild Blueberry Project Reports was prepared for the Wild Blueberry Commission of Maine and the Wild Blueberry Advisory Committee by researchers at the University of Maine, Orono. Projects in this report include: 1. Development of effective intervention measures to maintain and improve food safety for wild blueberries 2. Do wild blueberries alleviate risk factors related to the Metabolic Syndrome? 3. Wild Blueberry consumption and exercise-induced Oxidative Stress: Inflammatory Response and DNA damage 4. Control tactics for blueberry pest insects, 2013 5. Pesticide residues on wild blueberry, 2013 6. Biology of pest insects and IPM, 2013 7. Biology of blueberry, beneficial insects, and blueberry pollination 8. Biology of spotted wing drosophila, 2013 9. Maine wild blueberry –mummy berry research and extension 10. Evaluation of fungicides for control of mummy berry on lowbush blueberry (2013) 11. Wild blueberry Extension Education Program in 2013 INPUT SYSTEMS STUDY: 12. Systems approach to improving the sustainability of wild blueberry production, Year Four of a four-year study – experimental design 13. Food safety- Prevalence study of Escherichia coli O157:H7, Listeria monocytogenes and Salmonella spp. on lowbush blueberries (Vaccinium angustifolium) 14. Agronomic input effects on sensory quality and chemical composition of wild Maine blueberries 15. Systems approach to improving the sustainability of wild blueberry production, Year four of a four-year study – reports from Frank Drummond 16. Systems approach to improving the sustainability of wild blueberry production, Year 4 of a four-year study, disease management results 17. Systems approach to improving the sustainability of wild blueberry production, Year Four of a four-year study, weed management results 18. Phosphorus and organic matter interactions on short-range ordered minerals in acidic barren soils 19. Systems approach to improving the sustainability of wild blueberry production, preliminary economic comparison for 2012-13 20. Ancillary projects in disease research (ancillary study) 21. Systems approach to improving the sustainability of wild blueberry production – Ancillary land-leveling study, Year Three of a four-year study (ancillary study) 22. Pre-emergent combinations of herbicides for weed control in wild blueberry fields – 2013 results from the 2012 trial (ancillary study) 23. Evaluation of herbicides for 2012 prune year control of fineleaf sheep fescue in wild blueberries – 2013 crop year results (ancillary study) 24. 2012 pre-emergence application timing and rate of Alion and Sandea in combination with Velpar or Sinbar – 2013 yields (ancillary study) 25. Pre-emergence Sinbar combinations for weed control in a non-crop wild blueberry field – 2012-2014 (ancillary study) 26. Evaluation of three pre-emergence herbicides alone and in combination with Velpar or Sinbar for effects on wild blueberry productivity and weed control (ancillary study) 27. Post-harvest control of red sorrel in a non-crop blueberry field, 2012-2014 (ancillary study) 28. Compost and mulch effects on soil health and nutrient dynamics in wild blueberry (ancillary study) 29. Evaluation of conventional and organic fertilizers on blueberry growth and yield (ancillary study

The Political Economy of Economic Reforms in Argentina

In 1989, Argentina entered a process of sweeping transformation of its economic institutions which provided for the (temporary) recovery of economic growth and the taming of inflation. The Argentine experience with market-oriented reforms has been regarded by the literature as a salient case of radical and 'unconstrained' reform. Yet, a closer scrutiny portrays that the building and maintenance of a pro-"reform coalition determined the pace, depth and characteristics of the 'new economic institutions'. The idiosyncrasies of Argentina's political institutions, in turn, conditioned this coalition-building strategy. The same idiosyncrasies were at play in the 2001/2002 collapse of the convertibility regime and ensuing social and political chaos.Political Economy, Economic Reforms, Argentina,

Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy

Endogenous costimulatory molecules on T cells such as 4-1BB (CD137) can be leveraged for cancer immunotherapy. Systemic administration of agonistic anti-4-1BB antibodies, although effective preclinically, has not advanced to phase 3 trials because they have been hampered by both dependency on Fc gamma receptor-mediated hyperclustering and hepatotoxicity. To overcome these issues, we engineered proteins simultaneously targeting 4-1BB and a tumor stroma or tumor antigen: FAP-4-1BBL (RG7826) and CD19-4-1BBL. In the presence of a T cell receptor signal, they provide potent T cell costimulation strictly dependent on tumor antigen-mediated hyperclustering without systemic activation by Fc gamma R binding. We could show targeting of FAP-4-1BBL to FAP-expressing tumor stroma and lymph nodes in a colorectal cancer-bearing rhesus monkey. Combination of FAP-4-1BBL with tumor antigen-targeted T cell bispecific (TCB) molecules in human tumor samples led to increased IFN-gamma and granzyme B secretion. Further, combination of FAP- or CD19-4-1BBL with CEA-TCB (RG7802) or CD20-TCB (RG6026), respectively, resulted in tumor remission in mouse models, accompanied by intratumoral accumulation of activated effector CD8(+) T cells. FAP- and CD19-4-1BBL thus represent an off-the-shelf combination immunotherapy without requiring genetic modification of effector cells for the treatment of solid and hematological malignancies