Consumers' Views on Local Food

This focus-group study investigated shoppers'’ beliefs and behaviors regarding local foods. Two of the four focus groups consisted of organic food shoppers. They were more committed to purchasing local foods and identified a much wider array of such foods than did the conventional shoppers. One group of conventional shoppers consisted of African-Americans, who tended to define “"local"” as a much larger geographic area than did the group of Caucasian conventional shoppers. The African-Americans were also less interested in local-food labels per se, despite being interested in the qualities associated with local foods: freshness, supporting local farmers, and developing personal relationships with food producers.Consumer/Household Economics,

Multi-stakeholder Governance in Cooperative Organizations: Toward a New Framework for Research?

ABSTRACTDespite the increasing popularity of multi-stakeholder cooperatives, social-economy researchers largely predict that these organizations will fail. Using a “cost of decision-making” approach, these researchers conclude that the governance structure of multi-stakeholder cooperatives makes this organizational model fundamentally untenable. In this paper, we review the empirical evidence available on multi-stakeholder cooperatives, which suggests that different groups of actors are able to govern themselves successfully. Consequently, we argue that the literature that has focused on the management of common pool resources by self-organized groups may be an appropriate body of literature in which to root a research program on these social-economy organizations.RÉSUMÉMalgré la popularité grandissante des coopératives à multiples intervenants, les chercheurs en économie sociale prédisent que ces organisations essuieront un échec. Grâce à une méthode des coûts pour la prise de décisions, ces chercheurs en viennent à la conclusion que la structure de gouvernance des coopératives à multiples intervenants, par sa nature, en fait un modèle organisationnel indéfendable. Dans cet article, nous examinons les éléments de preuve empiriques disponibles sur les coopératives à multiples intervenants, qui suggèrent que différents groups d’actants peuvent réussir à s’autogérer. Par conséquent, nous discutons du fait que la documentation qui porte sur la gestion des ressources communes par les groupes autogérés pourrait constituer un corpus approprié pour établir un programme de recherche sur ces organisations d’économie sociale.&nbsp

Can They Build or Not? Non-profit Housing Development in an Era of Government Re-engagement

In the context of new government investment in housing, this article explores the experiences of nonprofit organizations in securing support for new affordable rental housing development in three regions across Canada. Many challenges were reported, including ones pertaining to administration (extensive proposal requirements, lack of information and communication, and lengthy review processes), and the design of funding programs (such as a lack of flexibility available to proponents). Participants also reported limitations to the amount and nature of support provided, challenges working across different levels of government, and an uneven playing field among nonprofit and for-profit housing developers. Overall, results show that despite significant and recent investments made available for affordable housing, the nonprofit sector faces many barriers in accessing these, and that significant changes are required so that housing organizations may provide rental units to those in greatest need

On the Front Lines: Nonprofits in the Homeless-serving Sector During the COVID-19 Pandemic

This article examines the experiences of the nonprofit, homeless-serving sector during the first wave of the COVID-19 pandemic. Qualitative interviews were conducted with staff and volunteers from frontline organizations in the two largest communities in Nova Scotia, Canada. Participants reported much strain on their organizations' human resources, but also the ability to adjust service delivery mechanisms quickly in order to continue offering supports. Most reported greater in-kind contributions from businesses and community members as well as more funding from the federal government in particular, albeit with administrative burdens and defined timelines. Nonprofits played a leadership role in developing responses to serve the needs of those experiencing homelessness, including developing comfort centres, installing portable toilets in downtown locations, and moving those without housing into hotels. They also advocated to government for state-level responses to those without housing, including calls to invest in new units and enhance funding for frontline service providers. At the same time, nonprofits reported working across sectors, noting better communication and relationships with state actors as well as other nonprofit organizations as a result of their COVID-19 response

Sulfation of L-Selectin Ligands by an HEV-Restricted Sulfotransferase Regulates Lymphocyte Homing to Lymph Nodes

AbstractLymphocytes home to lymph nodes, using L-selectin to bind specific ligands on high endothelial venules (HEV). In vitro studies implicate GlcNAc-6-sulfate as an essential posttranslational modification for ligand activity. Here, we show that genetic deletion of HEC-GlcNAc6ST, a sulfotransferase that is highly restricted to HEV, results in the loss of the binding of recombinant L-selectin to the luminal aspect of HEV, elimination of lymphocyte binding in vitro, and markedly reduced in vivo homing. Reactivity with MECA 79, an adhesion-blocking mAb that stains HEV in lymph nodes and vessels in chronic inflammatory sites, is also lost from the luminal aspects of HEV. These results establish a critical role for HEC-GlcNAc6ST in lymphocyte trafficking and suggest it as an important therapeutic target

Evolution of ecological specialization and venom of a predatory marine gastropod

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74591/1/j.1365-294X.2007.03627.x.pd

Plasmid-Encoded Proinsulin Preserves C-Peptide While Specifically Reducing Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes

In type 1 diabetes (T1D) an intense inflammatory response destroys β cells in the pancreas, where insulin is produced and released. A therapy for T1D that reduces the specific autoimmune response in this disease while leaving the remainder of the immune system intact has long been sought. Proinsulin is a major target of adaptive immunity in T1D. We hypothesized that an engineered DNA plasmid encoding proinsulin (BHT-3021) would preserve β cell function in T1D patients through reduction of insulin-specific T cells. We studied 80 subjects over 18 years of age who were diagnosed with T1D within 5 years. Subjects were randomized 2:1 to receive intramuscular injections of BHT-3021 or BHT-placebo, weekly for 12 weeks, and then monitored for safety and immune responses in a blinded fashion. Four dose levels of BHT-3021 were evaluated: 0.3, 1.0, 3.0, and 6.0 mg. C-peptide served as an exploratory measure of efficacy and safety. Islet-specific CD8+ T cell frequencies were assessed with multimers of monomeric human leukocyte antigen class I molecules loaded with peptides containing pancreatic or unrelated antigens. No serious adverse events related to BHT-3021 occurred. C-peptide levels improved relative to placebo at all doses, most notably at 1 mg at 15 weeks (+19.5% BHT-3021 versus −8.8% BHT-placebo, P < 0.026). Proinsulin-reactive CD8+ T cells, but not T cells against unrelated islet or foreign molecules, declined in the BHT-3021 arm (P < 0.006). Thus, we demonstrate that a plasmid encoding proinsulin reduces the frequency of CD8+ T cells reactive to proinsulin while preserving C-peptide over the course of dosing

The 3 Levels Of Outcomes: A Framework For Evaluating Multidimensional CED

CED organizations can undertake a tremendous range of activities in the service of their constituents and communities. This article reports on how one CED organization (see Torjman, 2000 as well) clarified the outcomes they desired from a particularly complex initiative and then established a process and chose methodologies that enabled progress to be tracked at the individual/family, organization/business, and community/network levels