Preliminary report on the CTS transient event counter performance through the 1976 spring eclipse season

The transient event counter (TEC), senses and counts transients having a voltage rise of greater than five volts in three separate wire harnesses: the attitude control harness, the solar array instrumentation harness and the solar array power harness. The operational characteristics of TEC are defined and the preliminary results obtained through the first 90 days of operation including the spring 1976 eclipse season are presented. The results show that the Communications Technology Satellite was charged to the point where discharges occurred. The discharge induced transients did not cause any anomalous events in spacecraft operation. The data indicate that discharges can occur at any time during the day without preference to any local time quadrant. The number of discharges occurring in the one second sample interval are greater than anticipated. The compilation and review of the data is continuing

Are vitiligo treatments cost-effective? A systematic review

Vitiligo is characterised by well demarcated, cutaneous, macular depigmentation, with worldwide prevalence estimated to be between 0.2-1.8% [1]. Vitiligo treatments aim to encourage re-pigmentation and include topical corticosteroids, calcineurin inhibitors and NB-UVB phototherapy. Camouflage can also be prescribed to help mask the appearance of vitiligo, although this is frequently only prescribed for the face

Lower limb cellulitis: low diagnostic accuracy and underdiagnosis of risk factors

Accurate diagnosis and recognition of predisposing factors has been shown to be challenging in lower limb cellulitis. Assessment of 1746 consecutive cellulitis patients presenting to a UK university hospital showed increasing overdiagnosis with only 31.9% of referred patients with confirmed lower-limb cellulitis between 2015-2018. Recognition of at least one predisposing factor increased from 61% to 89% following introduction of more specific screening questions. This identified a need for better primary care dermatology education and the benefit of a proforma with specific screening questions for reversible predisposing factors for lower limb cellulitis. This article is protected by copyright. All rights reserved

Beneficial effect of ustekinumab in familial pityriasis rubra pilaris with a new missense mutation in CARD14

Pityriasis rubra pilaris (PRP) represents a group of rare chronic inflammatory skin disorders in which ~1 in 20 affected individuals show autosomal dominant inheritance. In such cases, there may be gain-of-function mutations in CARD14, encoding caspase recruitment domain-containing protein 14 (CARD14) that activates the non-canonical nuclear factor-kappa B (NF-κB) pathway, thereby promoting cutaneous inflammation. Here, we report a mother and son with PRP due to a new missense mutation in CARD14 and describe the beneficial clinical effects of ustekinumab, a monoclonal antibody against interleukins-12 and -23, in both subjects. A 49 year-old female and her 20 year-old son had lifelong, generalised, patchy erythematous scale with a few islands of sparing, as well as minor nail ridging and mild palmoplantar keratoderma, features consistent with generalised PRP. Topical steroids, phototherapy and oral retinoids proved ineffective therapies. Following informed consent, Sanger sequencing of CARD14 in both individuals revealed a new heterozygous single nucleotide transversion in exon 16, c.356T>G, resulting in the missense mutation, p.Met119Arg. Ustekinumab, at a dose of 45mg every 12 weeks, brought about a significant physical and emotional improvement in both the mother and son within a few days of the initial dose, which was sustained on maintenance dosing. This report highlights the therapeutic potential of biologics that downregulate NF-kB signalling in familial PRP with mutations in CARD14. This article is protected by copyright. All rights reserved

A New Approach to Non-Commutative U(N) Gauge Fields

Based on the recently introduced model of arXiv:0912.2634 for non-commutative U(1) gauge fields, a generalized version of that action for U(N) gauge fields is put forward. In this approach to non-commutative gauge field theories, UV/IR mixing effects are circumvented by introducing additional 'soft breaking' terms in the action which implement an IR damping mechanism. The techniques used are similar to those of the well-known Gribov-Zwanziger approach to QCD.Comment: 11 pages; v2 minor correction

Clinical response to antibiotic regimens in lower limb cellulitis: a systematic review

There is variation in the treatment of lower limb cellulitis (LLC) with no agreement on the most effective antibiotic regimen. Many patients with cellulitis fail to respond to first-line antibiotics. This can negatively affect patient care and result in unnecessary hospital admissions. The aim of this systematic review was to determine the clinical response and safety of antibiotic regimens for the management of LLC. A systematic review for randomized controlled trials (RCTs) was conducted using OVID MEDLINE, Ovid Embase and Cochrane Central Register of Controlled Trials in January 2019. Outcomes of interest included the clinical response to antibiotic regimens (type, dose, route, duration) and the safety of antibiotics in LLC. Trial quality was identified using the Cochrane Risk of Bias tool. Four RCTs were included. All included studies showed no significant differences between the clinical response to different antibiotic type, administration route, treatment duration or dose. LLC may be overtreated and shorter courses of oral antibiotics, possibly with lower doses, may be more suitable. There is a lack of published data on the clinical response and safety of antibiotics in LLC. Three studies were high risk for bias overall. Further high-quality studies may help determine whether less intensive antibiotic regimens can effectively treat LLC

N=1/2 Supersymmetric gauge theory in noncommutative space

A formulation of (non-anticommutative) N=1/2 supersymmetric U(N) gauge theory in noncommutative space is studied. We show that at one loop UV/IR mixing occurs. A generalization of Seiberg-Witten map to noncommutative and non-anticommutative superspace is employed to obtain an action in terms of commuting fields at first order in the noncommutativity parameter tetha. This leads to abelian and non-abelian gauge theories whose supersymmetry transformations are local and non-local, respectively.Comment: One reference added, published versio

Eccrine Porocarcinoma of the Skin is Rising in Incidence in the East of England

[No abstract available