Erosive pustular dermatosis of the scalp - is it really a rare condition?

Introduction. Erosive pustular dermatosis of the scalp (EPDS) is a rare disorder of unknown etiology that usually occurs in the elderly and is characterized by multiple pustules, erosions and crusts that appear on the scalp leading to scarring alopecia. The histopathology and laboratory tests are not specific which is the reason that EPDS is a frequently misdiagnosed condition. Case report. We presented two patients with EPDS. The first patient had the known history of local trauma, both patients had chronic recidivant process, classic clinical presentations, and nonspecific histological findings. Each patient had prompt therapeutical response to potent topical steroids. Conclusion. The diagnosis of EPDS can be made if a condition fulfills the following criteria: atrophic or actinic damaged skin, clinical association of erosions, pustules, scales and crusts, no specific histopathology, no infectious agent found responsible for the condition, and chronic course leading to scarring alopecia, and prompt response to the treatment with topical steroids. The history of chemical or physical trauma is often present

The expression of estrogen receptor beta in precancerous prostate lesions and adenocarcinoma

Adenokarcinom prostate (PCa) je najčešći karcinom u muškaraca. Intraepitelne prostatične neoplazme visokog gradusa (HGPIN) su lezije koje prethode nastanku invazivnog karcinoma i podrazumevaju kompletno odsustvo bazalnih ćelija i invaziju strome malignim acinusima. Estrogeni receptor β (ERβ) se nalazi u jedrima bazalnih i sekretornih ćelija acinusa i delimično u stromalnim ćelijama. Cilj istraživanja je da prikaže i lokalizuje ERβ u različitim morfološkim lezijama prostate: hiperplaziji (BHP), PINu i u PCa sa različitim Gleason scorom. Pretpostavlja se da prekancerozne lezije u svojim različitim fazama evolucije ne koreliraju u potpunosti sa ekspresijom ERβ. LGPIN pokazuje ekspresiju, dok u HGPINu nema ekspresije. Takođe je pretpostavka da ekspresija ERβ postoji u većine srednje diferentovanih PCa, te da se ekspresija posmatranog receptora gubi sa porastom Gleason scora. Ispitivano je pet grupa bolesnika:  kontrolna grupa sa BHP i četiri eksperimentalne grupe (PIN i 3 različite grupe PCa). Studija je sprovedena na muškarcima različite starosti u periodu 2010–2012. Nijedan pacijent nije prethodno primio hormonsku terapiju. Sekstant biopsije prostate su bojene na ERβ (Novocastra). Lokalizacija i intenzitet ERβ ekspresije prikazani su kroz skor: 0 = nula; 1 = 66%. Pozitivni fibroblasti i endotelne ćelije su korišćene za poređenje. Smanjena ekspresija ERβ primećena je kod malignih i premalignih lezija prostate naspram BHP. Ekspresija ERβ u epitelnim ćelijama acinusa bila je najslabija u dobro diferentovanim PCa. Kod BHP i dobro diferentovanih PCa bila je veća ekspresija ERβ u bazalnim ćelijama nego u sekretornim. Loše diferentovani PCa prikazali su smanjenje ekspresije ERβ u bazalnim ćelijama. Ukupna ćelijska ekspresija ERβ predstavlja složen i ponekad moguće paradoksalan nalaz, na osnovu čega primarni PCa zadržava ekspresiju ovog receptora, ali ipak značajno nižu u poređenju sa benignim epitelom i premalignim lezijama. Ovaj nalaz podupire stanovište o antiproliferativnoj ulozi ERβ u tkivu prostate.Adenocarcinoma of the prostate (PCa) is the most common cancer in men. High-grade prostatic intraepithelial neoplasia (HGPIN) are lesions that precede to invasive carcinomas and include complete absence of basal cells and stromal invasion by malignant acini. Estrogen receptor ß(ERß) is located in the nuclei of basal and secretory cells and partly in stromal ones.The aim of the research is to describe and localize ERß in different morphological lesions: prostate hyperplasia (BPH), PIN and PCa with different Gleason score. It is assumed that pre-cancerous lesions in different stages of their evolution not correlate completely with the expression ERß. LGPIN shows expression, while there is no expression in HGPIN. It is also an assumption that the expression ERß exists in most medium differentiated PCa, and that the expression of this receptor loses with increasing of Gleason score. Five groups of patient were investigated: control group with BPH and four experimental groups (PIN and 3 different groups of PCa). The study was conducted on men of different ages in the period 2010-2012. None of the patients received prior hormonal therapy. Sextant prostate biopsy were stained on ERß (Novocastra). ERß expression is shown through the score: 0 = zero; 1 = 66%. Positive fibroblasts and endothelial cells were used for comparison. Reduced expression was observed in malignant and premalignant lesions of the prostate versus BPH. ERß expression in the epithelial cells of acini was the weakest in well-differentiated PCa. In BPH and well differentiated PCa was greater expression in the basal cells than in secretory ones. Poorly differentiated PCa showed a decreased ERß expression in basal cells. Total cellular expression of ERß is a complex and sometimes paradoxical finding on the basis of which the primary PCa retains expression of this receptor, but significantly lower compared to benign epithelium and premalignant lesions. This finding supports the antiproliferative role of ERß in prostate tissue

Intranazalni pleomorfni adenom podrijetlom iz lateralne stijenke nosa

Pleomorphic adenoma is very rare in the sinonasal region, with the most common localization on the nasal septum, followed by lateral nasal wall. In the case presented, a 72-year-old woman was complaining of the right sided nasal obstruction without any other symptoms. The symptom started a year before and increased progressively. Anterior rhinoscopy revealed a mucosa-covered, smooth-surfaced, soft, polypoid, pale, grayish-pink in color mass in the right nasal cavity, approximately 2x2 cm in size. Nasal endoscopy showed the mass to have a broad base on the lateral nasal wall. Computerized tomography scan showed a homogeneous, solid soft tissue mass, 25x18x12 mm in size, which was attached to the lateral nasal wall, behind the nasal vestibule, just in front of the inferior turbinate. Endonasal endoscopic complete tumor excision was performed, during which some spillage of the tumor occurred. Histology diagnosis was pleomorphic adenoma of minor salivary glands. The patient was followed up on regular basis and had no tumor recurrence in the 6th postoperative year. Intranasal pleomorphic adenoma arising from the lateral nasal wall in front of the inferior turbinate is extremely rare, so the presented case is probably the first ever published.Pleomorfni adenom je veoma rijedak u sinonazalnoj regiji, pričem je najučestalija lokalizacija septum, zatim lateralna stijenka nosa. U prikazanom slučaju bolesnica u dobi od 72 godine se žalila na unilateralnu začepljenost nosa, bez drugih simptoma. Zapušenost nosa joj se javila godinu dana prije pregleda i progresivno se pogoršavala. Prednjom rinoskopijom joj je u nosu desno uočena izraslina prekrivena sluznicom, glatke površine, polipoidna, meke konzistencije, blijedo sivkasto-ružičaste boje, veličine oko 2x2 cm. Endoskopija nosa je utvrdila da je polazište izrasline široko i da se nalazi na lateralnoj stijenci nosa. Kompjutoriziranom tomografijom je utvrđena homogena, solidna, mekotkivna masa veličine 25x18x12 mm spojena na lateralnu stijenku nosa, odmah iza vestibula. a neposredno ispred donje nosne školjke. Načinjena je endonazalna endoskopska kompletna ekscizija tumora tijekom koje je došlo do djelomičnog istjecanja sadržaja tumora. Patohistološka dijagnoza je bila pleomorfni adenom malih žlijezda slinovnica. Bolesnica je redovito praćena i kontrolirana, nije bilo recidiva tumora u šestoj poslijeoperacijskoj godini. Intranazalni pleomorfni adenom s polazištem na lateralnoj stijenci nosa ispred donje nosne školjke je iznimno rijedak pa je prikazani slučaj vjerojatno prvi ikada publiciran

OLIY TA'LIM XIZMATLARI KO'LAMLARI RIVOJLANISHI VA SAMARADORLIGINING O'ZIGA XOS KO'RSATKICHLARI

Ushbu maqolada олий таълим соҳасидаги муассасаларда ta’lim xizmatlari ko‘lamlari rivojlanishi va samaradorligining o‘ziga xos ko‘rsatkichlarini aniqlash, ularga mos tavsiyalarni tayyorlab, amaliyotga tadbiq etishdan iborat

The expression of estrogen receptor beta in precancerous prostate lesions and adenocarcinoma

Adenokarcinom prostate (PCa) je najčešći karcinom u muškaraca. Intraepitelne prostatične neoplazme visokog gradusa (HGPIN) su lezije koje prethode nastanku invazivnog karcinoma i podrazumevaju kompletno odsustvo bazalnih ćelija i invaziju strome malignim acinusima. Estrogeni receptor β (ERβ) se nalazi u jedrima bazalnih i sekretornih ćelija acinusa i delimično u stromalnim ćelijama. Cilj istraživanja je da prikaže i lokalizuje ERβ u različitim morfološkim lezijama prostate: hiperplaziji (BHP), PINu i u PCa sa različitim Gleason scorom. Pretpostavlja se da prekancerozne lezije u svojim različitim fazama evolucije ne koreliraju u potpunosti sa ekspresijom ERβ. LGPIN pokazuje ekspresiju, dok u HGPINu nema ekspresije. Takođe je pretpostavka da ekspresija ERβ postoji u većine srednje diferentovanih PCa, te da se ekspresija posmatranog receptora gubi sa porastom Gleason scora. Ispitivano je pet grupa bolesnika:  kontrolna grupa sa BHP i četiri eksperimentalne grupe (PIN i 3 različite grupe PCa). Studija je sprovedena na muškarcima različite starosti u periodu 2010–2012. Nijedan pacijent nije prethodno primio hormonsku terapiju. Sekstant biopsije prostate su bojene na ERβ (Novocastra). Lokalizacija i intenzitet ERβ ekspresije prikazani su kroz skor: 0 = nula; 1 = 66%. Pozitivni fibroblasti i endotelne ćelije su korišćene za poređenje. Smanjena ekspresija ERβ primećena je kod malignih i premalignih lezija prostate naspram BHP. Ekspresija ERβ u epitelnim ćelijama acinusa bila je najslabija u dobro diferentovanim PCa. Kod BHP i dobro diferentovanih PCa bila je veća ekspresija ERβ u bazalnim ćelijama nego u sekretornim. Loše diferentovani PCa prikazali su smanjenje ekspresije ERβ u bazalnim ćelijama. Ukupna ćelijska ekspresija ERβ predstavlja složen i ponekad moguće paradoksalan nalaz, na osnovu čega primarni PCa zadržava ekspresiju ovog receptora, ali ipak značajno nižu u poređenju sa benignim epitelom i premalignim lezijama. Ovaj nalaz podupire stanovište o antiproliferativnoj ulozi ERβ u tkivu prostate.Adenocarcinoma of the prostate (PCa) is the most common cancer in men. High-grade prostatic intraepithelial neoplasia (HGPIN) are lesions that precede to invasive carcinomas and include complete absence of basal cells and stromal invasion by malignant acini. Estrogen receptor ß(ERß) is located in the nuclei of basal and secretory cells and partly in stromal ones.The aim of the research is to describe and localize ERß in different morphological lesions: prostate hyperplasia (BPH), PIN and PCa with different Gleason score. It is assumed that pre-cancerous lesions in different stages of their evolution not correlate completely with the expression ERß. LGPIN shows expression, while there is no expression in HGPIN. It is also an assumption that the expression ERß exists in most medium differentiated PCa, and that the expression of this receptor loses with increasing of Gleason score. Five groups of patient were investigated: control group with BPH and four experimental groups (PIN and 3 different groups of PCa). The study was conducted on men of different ages in the period 2010-2012. None of the patients received prior hormonal therapy. Sextant prostate biopsy were stained on ERß (Novocastra). ERß expression is shown through the score: 0 = zero; 1 = 66%. Positive fibroblasts and endothelial cells were used for comparison. Reduced expression was observed in malignant and premalignant lesions of the prostate versus BPH. ERß expression in the epithelial cells of acini was the weakest in well-differentiated PCa. In BPH and well differentiated PCa was greater expression in the basal cells than in secretory ones. Poorly differentiated PCa showed a decreased ERß expression in basal cells. Total cellular expression of ERß is a complex and sometimes paradoxical finding on the basis of which the primary PCa retains expression of this receptor, but significantly lower compared to benign epithelium and premalignant lesions. This finding supports the antiproliferative role of ERß in prostate tissue

OLIY TA'LIM MUASSASALARIDA TA'LIM XIZMATLARINI STRATEGIK REJALASHTIRISH JARAYONLARINING UMUMIY HUSUSIYATLARI

Ushbu maqolada oliy taʼlim sohasidagi muassasalardagi past strategik darajasini hisobga olgan holda, o‘rta muddat uchun belgilangan missiyaning maqsadi “sifatli xizmat ko‘rsatish” ni o‘zlashtirish va strategik rejalashtirishni amalga oshirish yani, OTMda ichki va tashqi muhitga yo‘naltirilgan samarali xizmat ko‘rsatishni tashkil etish, ularga mos tavsiyalarni tayyorlab, amaliyotga tadbiq etishdan iborat

Radical cystectomy: Analysis of postoperative course

Background/Aim. Radical cystectomy is a method of choice in the therapy of infiltrative bladder cancer. The aim of this research was to analyze postoperative course after radical cystectomy (length of hospitalization, most frequent complications and utilization of antibiotics and transfusions). Methods. We analyzed the records of 82 patients operated on in the Department of Urology, Clinical Center of Vojvodina, in a three-year period. In order to aquire data World Health Organization (WHO) has developed Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) methodology. Defined daily dose (DDD) is the assumed average maintenance dose per day for a drug use for its main indication. Results. Continent urinary derivation was preformed in 23.15% cases. Postoperative complications occurred in 18.29% of patients. Average blood utilization was 2.19 units. Blood utilization for continent derivations (n = 48) was 4.6 units, and incontinent ones 3.36 units. Totally 159.33 DDD/100 bed days were used. Conclusion. When preforming continent derivation there is a significant increase in blood utilization. Frequency of postoperative complications correlates to those reported in the literature

Primary Umbilical Endometriosis: A Case Report

Endometriosis (EM) is defined as extrauterine functional endometrial tissue, commonly found in the pelvic peritoneum, ovaries, or rectovaginal septum. This is a chronic condition that affects 6-15% women of reproductive age and 6% of postmenopausal women (1). The most common symptoms are dysmenorrhea and dyspareunia (1), although 20-25% patients are asymptomatic (1-3). Infertility affects 30- 50% of patients (2)

Primary Umbilical Endometriosis: A Case Report

Endometriosis (EM) is defined as extrauterine functional endometrial tissue, commonly found in the pelvic peritoneum, ovaries, or rectovaginal septum. This is a chronic condition that affects 6-15% women of reproductive age and 6% of postmenopausal women (1). The most common symptoms are dysmenorrhea and dyspareunia (1), although 20-25% patients are asymptomatic (1-3). Infertility affects 30- 50% of patients (2)

СУЩЕСТВОВАНИЕ ИЗМЕРИМЫХ СОГЛАСОВАННЫХ СЕЛЕКТОРОВ МНОГОЗНАЧНЫХ ОТОБРАЖЕНИЙ

The present article is devoted to considering measurable set-valued random functions that are adapted to a fixed filtration of σ-algebras and the values of which are closed subsets of some complete separable metric space. For such functions, a criterion of measurability and adaptation is proved, which is analogous to Castain’s well-known criterion of measurability of set-valued functions. A theorem on existence of measurable and adapted selectors of set-valued random functions, which approximate some measurable adapted random function, is obtained. This theorem is improved in the case of set-valued functions with compact values. The generalization of Filippov’s theorem about the inverse function to the set-valued measurable random functions is proved. The obtained results can be useful both for proving the existence and for considering the properties of the solutions of stochastic differential inclusions.В настоящей статье рассматриваются измеримые многозначные случайные отображения, согласованные с заданным потоком σ-алгебр, значениями которых являются замкнутые подмножества некоторого полного сепарабельного метрического пространства. Для них установлен критерий измеримости и согласованности, аналогичный известному критерию Кастэна измеримости многозначных отображений. Доказана теорема о существовании у случайных многозначных отображений измеримых и согласованных селекторов, с заданной точностью аппроксимирующих некоторую однозначную измеримую и согласованную случайную функцию. Данная теорема усилена в случае, когда рассматриваемое многозначное отображение принимает компактные значения. Доказана теорема, обобщающая на многозначные измеримые случайные отображения теорему Филиппова об обратной функции. Полученные результаты могут быть использованы при доказательстве существования и исследовании свойств решений стохастических дифференциальных включений.