Steroid metabolism In vitro by the adrenal cortex from male and female monkeys, macca mulatta

1. 1. Biosynthesis of steroid hormones from radioactive progesterone, 17[alpha]-hydroxyprogesterone, androst-4-ene-3, 17-dione and testosterone by the adrenals of male and female Rhesus monkeys was studied.2. 2. On a comparative basis the adrenals from the female monkeys yielded a higher ratio of estrogens to androst-4-ene-3, 17-dione and/or testosterone among the biosynthetic products.3. 3. Probably due to the common embryologic origin, the sex chromatin constitution (XX, or XY) reflected is not only in gonadal but also in adreno-cortical enzyme activities.4. 4. Following gonadectomy, decreased sex difference in the biosynthetic activities of the adrenals was observed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32872/1/0000250.pd