Colchicine may decrease cardiovascular events in patients with coronary artery disease

This oral anti-inflammatory agent may offer a low-cost option for prevention of cardiovascular events in this patient population.Leslie Griffin, MD; Julia Groce, MD; Sara Conway, MD (University of Tennessee, College of Medicine, Chattanooga). Deputy Editor: Corey Lyon, DO (University of Colorado, Denver)Includes bibliographical reference

Teaching Advanced Technology with Higher Education: Computer Animation, Film Production and Broadcasting

This panel will discuss the current industry trend of Animation Technology and how it effects and changes the higher education from the history of Animation & Film, 2d & 3D Animation, Motion Graphic Animation and Motion Capture Animation fields. Through this presentation and peers discussions we should have a strong understanding of how the modern animation technology transform the traditional animation in current industry and higher education

Phonologic Rehabilitation of Anomia in Aphasia

The single most common feature of aphasia is impairment in ability to name, whether it involves naming seen objects, or producing nouns, verbs and other words conveying meaning in spontaneous language. The traditional treatment approach to this problem is to explicitly train aphasic patients in naming. Controlled studies have shown that this approach may be quite effective. However, typically generalization is very limited, that is, the knowledge gained by the patient tends to be limited to the words actually trained, and there is at best very modest improvement in performance with untrained words (limited mainly to those that are semantically related to the trained words). Because generalization is can be limited with this approach, there currently exists no viable means of training patients on the full corpus of words (perhaps several thousand) they are likely to need in daily life. Two approaches might be taken to solving this problem: 1) develop cost effective means for providing training on several thousand words; and 2) develop alternative training methods, e.g., phonological therapy, that potentially could intrinsically generalize widely. The focus of this proposal is the second of these two approaches. Thus, the primary purpose of this Phase II clinical rehabilitation study was to examine the effect of a phonologic based treatment on confrontation naming by individuals with anomic aphasia. We used a single-subject ABA design replicated across ten participants. The primary research question asked if phonologic treatment would improve confrontation naming. Secondary research questions addressed the impact of treatment on 1) generalization to untrained behaviors such as discourse production; 2) retention effects at 3-months; 3) phonologic production and 4) nonword repetition (potential evidence of phoneme sequence knowledge acquisition)

Neural Signatures of Semantic and Phonemic Fluency in Young and Old Adults

As we age, our ability to select and produce words changes, yet we know little about the underlying neural substrate of word-finding difficulties in old adults. The present study was designed to elucidate changes in specific frontally mediated retrieval processes involved in word-finding difficulties associated with advanced age. We implemented two overt verbal (semantic and phonemic) fluency tasks during functional magnetic resonance imaging and compared brain activity patterns of old and young adults. Performance during the phonemic task was comparable for both age-groups and mirrored by strongly left lateralized (frontal) activity patterns. On the other hand, a significant drop of performance during the semantic task in the older goup was accompanied by additional right (inferior and middle) frontal activity, which was negatively correlated with performance. Moreover, the younger group recruited different subportions of the left inferior frontal gyrus for both fluency tasks, while the older participants failed to show this distinction. Thus, functional integrity and efficient recruitment of left frontal language areas seems to be critical for successful word-retrieval in old age

Multi-modal Treatment of Phonological Alexia: Behavioral and Pilot fMRI Outcomes

Post-stroke phonological alexia is characterized by impaired reading of pseudowords, with relatively intact reading or orthographically irregular words. We conducted a single-subject repeated-probe research study of a multi-modal treatment of phonological processing and reading skills in five adults with phonological alexia. Based on the phonological deficit hypothesis, treatment tasks involved training written and verbal phonological skills. Visual inspection of repeated-probe graphs and standardized test scores provided evidence of improved phonological processing and real word reading skills for only some participants. One participant’s Pilot fMRI of overt pseudoword reading and pseudoword repeating exhibited perilesional and right-hemisphere neural reorganization

Developmental Toxicity of Nicotine: A Transdisciplinary Synthesis and Implications for Emerging Tobacco Products

While the health risks associated with adult cigarette smoking have been well described, effects of nicotine exposure during periods of developmental vulnerability are often overlooked. Using MEDLINE and PubMed literature searches, books, reports and expert opinion, a transdisciplinary group of scientists reviewed human and animal research on the health effects of exposure to nicotine during pregnancy and adolescence. A synthesis of this research supports that nicotine contributes critically to adverse effects of gestational tobacco exposure, including reduced pulmonary function, auditory processing defects, impaired infant cardiorespiratory function, and may contribute to cognitive and behavioral deficits in later life. Nicotine exposure during adolescence is associated with deficits in working memory, attention, and auditory processing, as well as increased impulsivity and anxiety. Finally, recent animal studies suggest that nicotine has a priming effect that increases addiction liability for other drugs. The evidence that nicotine adversely affects fetal and adolescent development is sufficient to warrant public health measures to protect pregnant women, children, and adolescents from nicotine exposure

Neighborhood Socioeconomic Status and Non School Physical Activity and Body Mass Index in Adolescent Girls

Socioeconomic status (SES) has well known associations with a variety of health conditions and behaviors in adults but is unknown in adolescents

Girls' Activity Levels and Lesson Contexts in Middle School PE: TAAG Baseline

To assess girls' physical activity (PA) in middle school physical education (PE) as it relates to field site, lesson context and location, teacher gender, and class composition