Formation a valeological culture of students

Описана структура валеологической культуры молодежи. Представлено социологическое осмысление различных типов поведения молодежи в сфере здоровья. Дан анализ результатов исследования возможностей поддержания личных ресурсов и сохранения здоровья студенческой молодежью.Describe the structure of valeological culture of the youth. Presented sociological understanding of different types of behaviour of young people in the field of health. Presented an analysis of the results of investigation of possibilities to maintain personal resources and preservation of health of the student youth

Self-preservation behavior as a component of demographic municipal policy

В статье дается определение молодежи как социальной общности, раскрывается вопрос о важности решения социальных и демографических проблем молодежи и о необходимости изменения социальной политики в отношении данной социально незащищенной категории населения. Показано, что существует несколько этапов влияния на потребность молодежи в самосохранительном поведении. Определена значимость самосохранительного поведения в демографической и муниципальной политике.This paper provides a definition of youth as a social community, revealed the importance of resolving social and demographic problems of youth and the need for changes in social policy in relation to this, socially vulnerable categories of society. It is shown that there are several stages of influence on young people and the need. The importance of self-preservation behavior in population and municipal politics

Practical observations - the COVID-19 influence on Latvian early intervention work with first episode psychosis (FEP) patients

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Formation of Personal Competitiveness of the Student in the Educational Space of the University

Рассмотрены особенности формирования конкурентоспособности студентов — будущих чиновников. Выделены проблемные поля в процессе конкурентоориентирования студенческой молодежи. Сформулирован ряд рекомендаций, направленных на совершенствование формирования конкурентоспособности студентов в образовательном пространстве университета.The article describes the features of the formation of the competitiveness of students - future officials. The problem fields in the process of competitive orientation of students are identified. We formulated a number of recommendations aimed at improving the formation of students’ ompetitiveness in the educational space of the university

Education of Adults as a Subject of Sociological Analysis

The article analyzes the results of sociological research of attitudes of adults to receive additional education; the problem field in the organization of the educational process is revealed. We have formulated conclusions that determine the possible directions of improvement of the organization of professional education of adults. It is proposed to consistently use the basic principles and procedures of the technological approach to eliminate problem areas in the process of organizing additional professional education.В статье проанализированы результаты социологического исследования установок взрослых на получение дополнительного образования; выявлено проблемное поле в организации образовательного процесса. Сформулированы выводы, определяющие возможные направления совершенствования организации профессионального образования взрослых. Предлагается последовательное использование основных принципов и процедур технологического подхода для устранения проблемных зон в процессе организации дополнительного профессионального образования.The article is prepared with the support of Russian Foundation for Basic Research, project № 19-011-00096 «Education as a resource for the preservation and development of the «third age» people».Исследование выполнено при финансовой поддержке РФФИ в рамках научного проекта № 19-011-00096 «Образование как ресурс сохранения и развития социальной общности людей "третьего возраста"»

Finite difference analysis and experimental validation of 3D photonic crystals for structural health monitoring

Copyright 2017 Society of Photo‑Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this publication for a fee or for commercial purposes, and modification of the contents of the publication are prohibited

Disruption of STAT3 signaling promotes KRAS induced lung tumorigenesis

STAT3 is considered to play an oncogenic role in several malignancies including lung cancer; consequently, targeting STAT3 is currently proposed as therapeutic intervention. Here we demonstrate that STAT3 plays an unexpected tumour-suppressive role in KRAS mutant lung adenocarcinoma (AC). Indeed, lung tissue-specific inactivation of Stat3 in mice results in increased KrasG12D-driven AC initiation and malignant progression leading to markedly reduced survival. Knockdown of STAT3 in xenografted human AC cells increases tumour growth. Clinically, low STAT3 expression levels correlate with poor survival and advanced malignancy in human lung AC patients with smoking history, which are prone to KRAS mutations. Consistently, KRAS mutant lung tumours exhibit reduced STAT3 levels. Mechanistically, we demonstrate that STAT3 controls NF-B-induced IL-8 expression by sequestering NF-B within the cytoplasm, thereby inhibiting IL-8-mediated myeloid tumour infiltration and tumour vascularization and hence tumour progression. These results elucidate a novel STAT3NF-BIL-8 axis in KRAS mutant AC with therapeutic and prognostic relevance.P 25599(VLID)183891

Induction and transmission of oncogene-induced senescence

Senescence is a cellular stress response triggered by diverse stressors, including oncogene activation, where it serves as a bona-fide tumour suppressor mechanism. Senescence can be transmitted to neighbouring cells, known as paracrine secondary senescence. Secondary senescence was initially described as a paracrine mechanism, but recent evidence suggests a more complex scenario involving juxtacrine communication between cells. In addition, single-cell studies described differences between primary and secondary senescent end-points, which have thus far not been considered functionally distinct. Here we discuss emerging concepts in senescence transmission and heterogeneity in primary and secondary senescence on a cellular and organ level

Imaging Pulmonary NF-kappaB Activation and Therapeutic Effects of MLN120B and TDZD-8

NF-κB activation is a critical signaling event in the inflammatory response and has been implicated in a number of pathological lung diseases. To enable the assessment of NF-κB activity in the lungs, we transfected a luciferase based NF-κB reporter into the lungs of mice or into Raw264.7 cells in culture. The transfected mice showed specific luciferase expression in the pulmonary tissues. Using these mouse models, we studied the kinetics of NF-κB activation following exposure to lipopolysaccharide (LPS). The Raw264.7 cells expressed a dose-dependent increase in luciferase following exposure to LPS and the NF-κB reporter mice expressed luciferase in the lungs following LPS challenge, establishing that bioluminescence imaging provides adequate sensitivity for tracking the NF-κB activation pathway. Interventions affecting the NF-κB pathway are promising clinical therapeutics, thus we further examined the effect of IKK-2 inhibition by MLN120B and glycogen synthase kinase 3 beta inhibition by TDZD-8 on NF-κB activation. Pre-treatment with either MLN120B or TDZD-8 attenuated NF-κB activation in the pulmonary tissues, which was accompanied with suppression of pro-inflammatory chemokine MIP-1ß and induction of anti-inflammatory cytokine IL-10. In summary, we have established an imaging based approach for non-invasive and longitudinal assessment of NF-κB activation and regulation during acute lung injury. This approach will potentiate further studies on NF-κB regulation under various inflammatory conditions

Association of kidney disease measures with risk of renal function worsening in patients with type 1 diabetes

Background: Albuminuria has been classically considered a marker of kidney damage progression in diabetic patients and it is routinely assessed to monitor kidney function. However, the role of a mild GFR reduction on the development of stage 653 CKD has been less explored in type 1 diabetes mellitus (T1DM) patients. Aim of the present study was to evaluate the prognostic role of kidney disease measures, namely albuminuria and reduced GFR, on the development of stage 653 CKD in a large cohort of patients affected by T1DM. Methods: A total of 4284 patients affected by T1DM followed-up at 76 diabetes centers participating to the Italian Association of Clinical Diabetologists (Associazione Medici Diabetologi, AMD) initiative constitutes the study population. Urinary albumin excretion (ACR) and estimated GFR (eGFR) were retrieved and analyzed. The incidence of stage 653 CKD (eGFR < 60 mL/min/1.73 m2) or eGFR reduction > 30% from baseline was evaluated. Results: The mean estimated GFR was 98 \ub1 17 mL/min/1.73m2 and the proportion of patients with albuminuria was 15.3% (n = 654) at baseline. About 8% (n = 337) of patients developed one of the two renal endpoints during the 4-year follow-up period. Age, albuminuria (micro or macro) and baseline eGFR < 90 ml/min/m2 were independent risk factors for stage 653 CKD and renal function worsening. When compared to patients with eGFR > 90 ml/min/1.73m2 and normoalbuminuria, those with albuminuria at baseline had a 1.69 greater risk of reaching stage 3 CKD, while patients with mild eGFR reduction (i.e. eGFR between 90 and 60 mL/min/1.73 m2) show a 3.81 greater risk that rose to 8.24 for those patients with albuminuria and mild eGFR reduction at baseline. Conclusions: Albuminuria and eGFR reduction represent independent risk factors for incident stage 653 CKD in T1DM patients. The simultaneous occurrence of reduced eGFR and albuminuria have a synergistic effect on renal function worsening