The Grizzly, November 20, 1981

Ursinus Takes First Step As Planning Gets Under Way • Successful Graduates Advise Seniors • Whatley Invited to Shuttle Launch • Ursinus\u27 Tuition Compared to Other Colleges • Sleigh Bells in September • Annual Messiah Concert Dec. 5 • Study Abroad Series: \u27Of Pints and Men\u27 • Variety Briefs: One-man band; Chamber orchestra performs; Cafe international • USGA Notes • Girls B-Ball Optimistic For New Season • Aquamen Drop Opener • Grapplers Do Well • Men\u27s B-Ball...Can They Do It Again? • Fine Showing in Regionals Sends Team to Wisconsin • Girls Splash to Victoryhttps://digitalcommons.ursinus.edu/grizzlynews/1068/thumbnail.jp

The Grizzly, December 5, 1980

Work Study Pay Increased To Minimum Wage • Chemistry Department Victimized by Malicious Pranks • Holiday Vacation Marred By Campus Break-ins • Richter Outlines Campus Concerns • Petition Shows Strong Support for Greaseband Return • Alumni Committee for Pre-Med Consultation • Wismer Corner • 1980 at Ursinus: The Year in Review • Southern Bands \u27Rock\u27 Spectrum • Handel\u27s \u27Messiah\u27 to Be Presented Tomorrow • Songfest Tradition Revived • Women\u27s Basketball Lookin\u27 Good • Basketball Off to Slow Start • Football Ends Victorioushttps://digitalcommons.ursinus.edu/grizzlynews/1049/thumbnail.jp

The Grizzly, November 21, 1980

Dean of Students\u27 Office Releases Vandalism Figures • Maintenance Working To Conserve Energy • Weight Room Relocated In Helfferich • College Union Attempts World\u27s Largest Molecule • Ursinus News In Brief: Espadas to speak today in Illinois; Maintenance planting new trees; Placement interviews coming soon • Rassias Method Explored for Languages • Journalism To Be Added To Curriculum • Medical Ethics Course Offered • Phil. & Rel. Dept. Lecture On Judaism • College To Host 43rd Messiah Performance • Foghat and Outlaws Perform for \u27Serious Rockers\u27 • Forum On Radiation Draws Mixed Views • Art Exhibit On Display In Wismer • Open House Planned By Astronomy Club • A Look At This Year\u27s Basketball Season • Cross Country To Compete In Nationals This Weekend • Gridders Lose Early Lead to Tie Gettysburghttps://digitalcommons.ursinus.edu/grizzlynews/1048/thumbnail.jp

The Grizzly, November 7, 1980

Reagan, Anderson Win In Campus Mock Election • Window Replacement To Start Soon • Weekend Crime Continues In New Men\u27s Dormitory • Bookstore Eyes Enlarged Facilities • Honorary Degrees Conferred At Founder\u27s Day • Library To Sponsor Open House • Breakdown For SAC Allocations Explored • Foreign Language Lunches Offered To Students • Another Viewpoint: I Object To War! • Students Do Their Stuff In Talent Show • Springsteen Unveils Interesting New Album • Party Brings Out Spirit On Halloween • Classics Club Underway • Why Carter Lost • UBEC Council Presents Three Faces Of Management • Soccer Finishes Season 7-7-1 • Breaks Carry Ursinus Past Lebanon Valley • Harriers Head Toward MACs • Field Hockey Enters Regional Competitionhttps://digitalcommons.ursinus.edu/grizzlynews/1046/thumbnail.jp

The Grizzly, October 17, 1980

Clouser Organizes Medical Advisory Committee • Union Rules Out Greaseband This Year • Freshman Class Appointments Available • Education Department Optimistic About Jobs • New Profs Appointed In German, History Depts. • Parents\u27 Day Brings Campus Enthusiasm • Staiger Named for State Committee • College Offers Numerous Special Programs • Coffeehouse Of \u27Distant Admiration\u27 • Radio WRUC Making Slow Return • Forum Presents Tyler and Althea • Parents\u27 Day Sees Gym Dedication • SAC Approves Two New Clubs • \u27Gong Show\u27 Provides Friday Night Fun • College Bowl Season Officially Opens • Heathens Take Intramural Title • Booters Kick Del Valley • Women\u27s Volleyball Faces Tough Schedule • Football Finds Season\u27s First W • Hockey Raises Record To 6-1-3https://digitalcommons.ursinus.edu/grizzlynews/1044/thumbnail.jp

The Grizzly, February 6, 1981

Computer Relocation Offers New Services • Breakage and Theft: Wismer Releases Alarming Loss Assessment • Borough Announces Water Alert • Weather Brings Maintenance Headaches • Departmental Focus: Chemistry • News Briefs: Speech exemption examination; Fraternity sponsors foster child; Resident assistant applications • USGA Notes • Union Announces Photo Contest • JDB in Transition • NY Trip A Must • UC Lorelei Tradition • Transplanted Texan • O\u27Neill\u27s First Union Appearance Success • Altered States Weakened • College Placement Office Expecting Busy Semester • NMD Waiting for Windows • Union Snack Shop Receives Needed Improvements • KDK Tops Sorority GPA List • Gymnastics Lookin\u27 Good • Women\u27s B-Ball Seen as Powerhouse • Basketball Still Holding First • W. Maryland Swamped by Swimmershttps://digitalcommons.ursinus.edu/grizzlynews/1051/thumbnail.jp

The Grizzly, October 3, 1980

Administration Focuses Attention On Pledging • Ritter Investigation Continues • Strangers Vandalize Beardwood Extinguishers • USGA Sponsors Alcohol Awareness Program • Women Experience the Excitement of Bid Day • College Disciplines Two Fraternities • Prof Appointed in Ec/BA • Photography Course Offered In Evening School • Values Education Examined By Committee • Candidates\u27 Platforms for Campus Elections • Classes of \u2781, \u2783 to Sponsor Gong Show • Album Review: Panorama: New View New Wave • Time Square Is Sheer Inspiration • Rush Returns to Philadelphia After Long Delay • Dingy Room Ideas Vol. II • Field Hockey Ties W&M; Beats Gettysburg • Volleyball Lookin\u27 Good • Awesome Widener Crunches Grizzlies • Sports Profile: Debbie Tweed • Cross Country Streak Alive • Despite 2-0 Loss, Booters Still Showing Promisehttps://digitalcommons.ursinus.edu/grizzlynews/1042/thumbnail.jp

The Grizzly, September 25, 1981

Greaseband Tonight • Campus Welcome • Fridge Fee Unfrozen • Deutsch und Deutschland Heute: German Professor Co-authors Text • Public Speaking Exemption Exam • Books Sought by Ursinus Friends • Red Cross Bloodmobile at Helfferich Hall • Career Planning and Placement Office • Dessert Held in Union • Fast Food Service Losing Convenience • ProTheatre: Canterbury Tales Presented • Transplanted Texan: Nobody Expects the Moral Majority • School Bands Looking for Musicians • WRUC: Back on the Air? • First Coffeehouse Sparkles With Talent • Late Mail for Off-Campus Houses • [Reprinted Articles About the Greaseband] • Bear\u27s Booters Kick Off Season • Business as Usual for Cross-Country • Bears Drop 10-3 Decision to Western Maryland • Davis Leads Hockey Over Widenerhttps://digitalcommons.ursinus.edu/grizzlynews/1061/thumbnail.jp

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Temporal Stability of Serum Concentrations of Cytokines and Soluble Receptors Measured Across Two Years in Low-Risk HIV-Seronegative Men

BackgroundProspective cohort studies often quantify serum immune biomarkers at a single time point to determine risk of cancer and other chronic diseases that develop years later. Estimates of the within-person temporal stability of serum markers partly assess the utility of single biomarker measurements and may have important implications for the design of prospective studies of chronic disease risk.MethodsUsing archived sera collected from 200 HIV-seronegative men at three visits spaced over approximately 2 years, concentrations of 14 biomarkers (ApoA1, sCD14, sgp130, sIL-6R, sIL-2Rα, sTNFR2, BAFF/BLyS, CXCL13, IFN-γ, interleukin [IL]-1β, IL-6, IL-8, IL-10, and TNF-α) were measured in a single laboratory. Age- and ethnicity-adjusted intraclass correlation coefficients (ICC) were calculated for each biomarker, and mixed linear regression models were used to examine the influence of age, ethnicity, season, and study site on biomarker concentrations.ResultsAcross all three study visits, most biomarkers had ICC values indicating fair to excellent within-person stability. ApoA1 (ICC = 0.88) and TNF-α (ICC = 0.87) showed the greatest stability; the ICC for IL-8 (ICC = 0.33) was remarkably less stable. The ICCs were similar when calculated between pairs of consecutive visits. The covariables did not influence biomarker levels or their temporal stability. All biomarkers showed moderate to strong pairwise correlations across visits.ConclusionsSerum concentrations of most evaluated immune biomarkers displayed acceptable to excellent within-person temporal reliability over a 2-year period. Further investigation may be required to clarify the stability of IL-8.ImpactThese findings lend support to using these serologic immune biomarkers in prospective studies investigating associations with chronic diseases