An Evidence-Based Approach for Decreasing Burnout in Health Care Workers

Practice Problem: Health care worker (HCW) burnout is a pervasive phenomenon within the healthcare industry, affecting professionals across various disciplines. Emotional exhaustion is a prominent feature, leading to feelings of being emotionally drained, overwhelmed, and unable to cope effectively with the demands of the job. Additionally, burnout often results in a significant lack of motivation among HCWs, who may struggle to find meaning and purpose in their work, exacerbating feelings of frustration and disillusionment. Consequences extend beyond individual well-being, impacting healthcare organizations with reduced work efficacy, low productivity, increased absenteeism, and high turnover rates. Addressing burnout requires a multifaceted approach, prioritizing supportive work environments, effective stress management strategies, and interventions aimed at promoting resilience and job satisfaction among healthcare professionals. PICOT: The PICOT question that guided this scholarly project was: In healthcare workers (P) how does the HeartMath techniques (I) compared to standard mental health care (C) affect symptoms of burnout (O) within 8 weeks (T)? Evidence: The literature evidence consistently demonstrated positive outcomes in preventing burnout among healthcare workers through the implementation of burnout prevention programs. These interventions equip healthcare professionals with the necessary tools and skills to effectively address their mental health challenges and uphold their physical well-being. By providing support mechanisms and promoting self-care practices, burnout prevention initiatives empower healthcare workers to proactively manage stressors inherent in their roles, thereby fostering resilience and sustaining optimal job performance. Such interventions not only benefit individual healthcare workers but also contribute to the overall functioning and quality of healthcare delivery systems. Intervention: The proposed intervention entailed implementing burnout management-based techniques developed by HeartMath within a primary care setting, aiming to mitigate burnout and address employment-related mental health concerns among staff. The program was designed to provide a sustainable framework for employees experiencing mental health challenges, ultimately enhancing their well-being, reducing absenteeism, and enhancing patient outcomes. This initiative sought to offer practical strategies for coping with workplace stressors, thereby fostering a healthier work environment and promoting the overall welfare of both healthcare providers and the patients they serve. Outcome: The results of this scholarly change project indicated a significant difference in the mean scores between pre- and posttests on the Personal and Organizational Quality Assessment (POQA-R4), suggesting the effectiveness of the HeartMath intervention in improving mental health status and work productivity. The findings demonstrated clinical significance, as evidenced by a notable decrease in burnout levels following participants\u27 exposure to the intervention. These outcomes underscore the potential impact of implementing HeartMath techniques to address burnout and promote overall well-being among individuals in professional settings. Conclusion: The implementation of the HeartMath\u27s burnout management-based techniques within a primary care setting demonstrated promising results in mitigating burnout and enhancing mental health status and work productivity among healthcare professionals. The significant difference observed between pre- and post-test scores highlights the clinical significance of this intervention. These findings underscore the potential value of incorporating such interventions into organizational strategies aimed at addressing burnout and improving overall staff well-being. Further research and implementation efforts in similar contexts may provide additional insights into the effectiveness and scalability of these approaches in healthcare and other professional settings

Checkmate to CHK1 in T-cell ALL?

© Impact Journals, LLC.DNA replication ensures accurate duplication of the original genetic information present in a cell in order for it to be properly transmitted to daughter cells. However, replication can be perturbed, for instance in rapidly dividing cancer cells, in a process referred to as replication stress (RS). Checkpoint kinase 1 (CHK1) is an essential component of the ATR-dependent DNA damageresponse pathway that protect cells from RS by preventing replication fork collapse and activating homologous DNA repair. The ATR-CHK1 pathway is triggered upon exposure of single-stranded DNA that arises with the stalling of replication forks, and it is required to reset proper origin firing, and to promote fork stability and checkpoint activation, delaying mitosis until replication is completed and thereby avoiding mitotic catastrophe.info:eu-repo/semantics/publishedVersio

Foeniculum vulgare Essential Oils: Chemical Composition, Antioxidant and Antimicrobial Activities

The essential oils from Foeniculum vulgare commercial aerial parts and fruits were isolated by hydrodistillation, with different distillation times (30 min, I h, 2 h and 3 h), and analyzed by GC and GC-MS. The antioxidant ability was estimated using four distinct methods. Antibacterial activity was determined by the agar diffusion method. Remarkable differences, and worrying from the quality and safety point of view, were detected in the essential oils. trans-Anethole (31-36%), alpha-pinene (14-20%) and limonene (11-13%) were the main components of the essentials oil isolated from F. vulgare dried aerial parts, whereas methyl chavicol (= estragole) (79-88%) was dominant in the fruit oils. With the DPPH method the plant oils showed better antioxidant activity than the fruits oils. With the TBARS method and at higher concentrations, fennel essential oils showed a pro-oxidant activity. None of the oils showed a hydroxyl radical scavenging capacity >50%, but they showed an ability to inhibit 5-lipoxygenase. The essential oils showed a very low antimicrobial activity. In general, the essential oils isolated during 2 h were as effective, from the biological activity point of view, as those isolated during 3 h.info:eu-repo/semantics/publishedVersio

Fish models of induced osteoporosis

Osteopenia and osteoporosis are bone disorders characterized by reduced bone mineral density (BMD), altered bone microarchitecture and increased bone fragility. Because of global aging, their incidence is rapidly increasing worldwide and novel treatments that would be more efficient at preventing disease progression and at reducing the risk of bone fractures are needed. Preclinical studies are today a major bottleneck to the collection of new data and the discovery of new drugs, since they are commonly based on rodent in vivo systems that are time consuming and expensive, or in vitro systems that do not exactly recapitulate the complexity of low BMD disorders. In this regard, teleost fish, in particular zebrafish and medaka, have recently emerged as suitable alternatives to study bone formation and mineralization and to model human bone disorders. In addition to the many technical advantages that allow faster and larger studies, the availability of several fish models that efficiently mimic human osteopenia and osteoporosis phenotypes has stimulated the interest of the academia and industry toward a better understanding of the mechanisms of pathogenesis but also toward the discovery of new bone anabolic or antiresorptive compounds. This mini review recapitulates the in vivo teleost fish systems available to study low BMD disorders and highlights their applications and the recent advances in the field.UIDB/04326/2020, EAPA_151/2016/BLUEHUMANinfo:eu-repo/semantics/publishedVersio

The miniJPAS survey : detection of the double-core Lyα morphology for two high-redshift QSOs

Context. The Lyα emission is an important tracer of neutral gas in a circum-galactic medium (CGM) around high-z quasi-stellar objects (QSOs). The origin of Lyα emission around QSOs is still under debate, bringing on significant implications for galaxy formation and evolution. Aims. In this paper, we study Lyα nebulae around two high redshift QSOs, SDSS J141935.58+525710.7 at z = 3.218 (hereafter QSO1) and SDSS J141813.40+525240.4 at z = 3.287 (hereafter QSO2), from the miniJPAS survey within the All-wavelength Extended Groth Strip International Survey (AEGIS) field. Methods. Using the contiguous narrow-band (NB) images from the miniJPAS survey and Sloan Digital Sky Survey (SDSS) spectra, we analyzed their morphology, nature, and origin. Results. We report the serendipitous detection of double-core Lyα morphology around two QSOs, which is rarely seen among other QSOs. The separations of the two Lyα cores are 11.07 ± 2.26 kpcs (1.47 ± 0.300) and 9.73 ± 1.55 kpcs (1.31 ± 0.2100), with Lyα line luminosities of ∼ 3.35 × 1044 erg s−1 and ∼ 6.99 × 1044 erg s −1 for QSO1 and QSO2, respectively. The miniJPAS NB images show evidence of extended Lyα and CIV morphology for both QSOs and extended HeII morphology for QSO1. Conclusions. These two QSOs may be potential candidates for the new enormous Lyman alpha nebula (ELAN) found from the miniJPAS survey due to their extended morphology in the shallow depth and relatively high Lyα luminosities. We suggest that galactic outflows are the major powering mechanism for the double-core Lyα morphology. Considering the relatively shallow exposures of miniJPAS, the objects found here could merely form the cusp of a promising number of such objects that will be uncovered in the upcoming full Javalambre-Physics of the Accelerated Universe Astrophysical Survey (J-PAS) survey and deep integral field units (IFU) observations with 8–10 m telescopes will be essential for constraining the underlying physical mechanism that is responsible for the double-cored morphology

First data of Iberian Nematomorpha, with redescription of <i>Gordius aquaticus</i> Linnaeus, <i>G. plicatulus</i> Heinze, <i>Gordionus wolterstorffii</i> (Camerano) and <i>Paragordius tricuspidatus</i> (Dufour)

Four species of Nematomorpha are recorded from NE Spain, representing the first reliable data on the group in the Iberian peninsula. Gordius aquaticits Linnaeus, 1758, G. plicatulus Heinze, 1937, Gordionus wolterstorffii (Camerano, 1888) and Paragordius tricuspidatus (Dufour, 1828) are redescribed based on scanning electron microscope observations. Notes on intraspecific morphological variation and ecology of the species are given.Facultad de Ciencias Naturales y Muse

First data of Iberian Nematomorpha, with redescription of <i>Gordius aquaticus</i> Linnaeus, <i>G. plicatulus</i> Heinze, <i>Gordionus wolterstorffii</i> (Camerano) and <i>Paragordius tricuspidatus</i> (Dufour)

Four species of Nematomorpha are recorded from NE Spain, representing the first reliable data on the group in the Iberian peninsula. Gordius aquaticits Linnaeus, 1758, G. plicatulus Heinze, 1937, Gordionus wolterstorffii (Camerano, 1888) and Paragordius tricuspidatus (Dufour, 1828) are redescribed based on scanning electron microscope observations. Notes on intraspecific morphological variation and ecology of the species are given.Facultad de Ciencias Naturales y Muse

Biomimetic apatite formation on different polymeric microspheres modified with calcium silicate solutions

Proceedings of the 18th International Symposium on Ceramics in Medicine, The Annual Meeting of the International Society for Ceramics in Medicine (ISCM), Kyoto, Japan, 5-8 December 2005. Published in : Key Enggineering Materials, vol. 309 - 311Bioactive polymeric microspheres can be produced by pre-coating them with a calcium silicate solution and the subsequent soaking in a simulated body fluid (SBF). Such combination should allow for the development of bioactive microspheres for several applications in the medical field including tissue engineering. In this work, three types of polymeric microspheres with different sizes were used: (i) ethylene-vinyl alcohol co-polymer (20-30 'm), (ii) polyamide 12 (10-30 'm) and (iii) polyamide 12 (300 'm). These microspheres were soaked in a calcium silicate solution at 36.5ºC for different periods of time under several conditions. Afterwards, they were dried in air at 100ºC for 24 hrs. Then, the samples were soaked in SBF for 1, 3 and 7 days. Fourier transformed infrared spectroscopy, thin-film X-ray diffraction, and scanning electron microscopy showed that after the calcium silicate treatment and the subsequent soaking in SBF, the microspheres successfully formed a bonelike apatite layer on their surfaces in SBF within 7 days due to the formation of silanol (Si-OH) groups that are quite effective for apatite formation.I. B. Leonor thanks the Portuguese Foundation for Science and Technology (FCT) for providing her a PhD scholarship (SFRH/BD/9031/2002) and the European Union funded STREP Project HIPPOCRATES (NMP3-CT-2003-505758) and the European NoE EXPERTISSUES (NMP3-CT-2004-500283)

Growth of a bonelike apatite on chitosan microparticles after a calcium silicate treatment

Bioactive chitosan microparticles can be prepared successfully by treating them with a calcium silicate solution and then subsequently soaking them in simulated body fluid (SBF). Such a combination enables the development of bioactive microparticles that can be used for several applications in the medical field, including injectable biomaterial systems and tissue engineering carrier systems. Chitosan microparticles, 0.6 lm in average size, were soaked either for 12 h in fresh calcium silicate solution (condition I) or for 1 h in calcium silicate solution that had been aged for 24 h before use (condition II). Afterwards, they were dried in air at 60 !C for 24 h. The samples were then soaked in SBF for 1, 3 and 7 days. After the condition I calcium silicate treatment and the subsequent soaking in SBF, the microparticles formed a dense apatite layer after only 7 days of immersion, which is believed to be due to the formation of silanol (Si– OH) groups effective for apatite formation. For condition II, the microparticles successfully formed an apatite layer on their surfaces in SBF within only 1 day of immersion.I.B.L. thanks the Portuguese Foundation for Science and Technology (FCT), for providing her a PhD scholarship (SFRH/BD/9031/2002), the European Union funded STREP Project HIPPOCRATES (NMP3-CT-2003-505758) and the European NoE EXPERTISSUES (NMP3-CT-2004-500283)

Populational analysis of Saccharomyces cerevisiae strains from different appellations of origin and grape varieties by microsatellite analysis.

The objective of the present study was to evaluate populational relationships among Saccharomyces cerevisiae strains isolated from some of the Portuguese most important grapevine varieties in different appellations of origin, using polymorphic microsatellites. &#xd;&#xa;One hundred ninety two grape samples were collected during the 2006 and 2007 harvest season in the Vinho Verde (grape varieties: Arinto, Alvarinho, Avesso, Loureiro, Touriga Nacional) Bairrada (grape varieties: Arinto, Baga, Castel&#xe3;o Franc&#xea;s, Maria Gomes, Touriga Nacional) Alentejo (grape varieties, Aragon&#xea;s, Trincadeira, Touriga Nacional), Terras do Sado (grape variety Castel&#xe3;o) Bucelas (grape variety Arinto) and Estremadura (grape varieties: Arinto, Aragon&#xea;s, Castel&#xe3;o, Trincadeira, Touriga Nacional) appellations of origin. From the final stage of spontaneous fermentations, 2820 yeast isolates were obtained, mainly belonging to the species S. cerevisiae. An initial genetic screen, based on mitochondrial DNA restriction fragment length polymorphism (mtDNA RFLP) and/or interdelta sequence analysis was followed by microsatellite analysis of strains with unique genetic profiles, using 10 highly polymorphic microsatellites. Our results showed that microsatellite analysis revealed a high resolution populational screen, showing that genetic differences and populational structures among S. cerevisiae populations derived from both &#x201c;diagnostic&#x201d; vineyard-, specific alleles and the accumulation of small allele-frequency differences across ten microsatellite loci. Heterozygosity was three to four times lower than the expected value, confirming the strong populational substructuring. The presented large-scale approach shows that each vineyard contains differentiated S. cerevisiae populations, showing the occurrence of specific native strains that can be associated with a terroir. &#xd;&#xa;&#xd;&#xa;Financially supported by the programs POCI 2010 (FEDER/FCT, POCTI/AGR/56102/2004) and AGRO (ENOSAFE, N&#xba; 762).&#xd;&#xa