Bioethics Authorship in Context: How Trends in Biomedicine Challenge Bioethics

This is an Author's Original Manuscript of an article whose final and definitive form, the Version of Record, has been published in The American Journal of Bioethics 2011. Available online at: http://www.tandfonline.com/ or DOI: 10.1080/15265161.2011.603808Resnik and Master (2011) propose a set of authorship guidelines for what they describe as “conceptual” papers in bioethics. These guidelines specifically address who should count as an author within multiply-authored conceptual research publications, given that various guidelines exist regarding empirical research in bioethics. Their arguments attend to an important and controversial issue, yet they do not take account of the broader historical and social contexts surrounding the growth of multiply-authored research publications. In this paper, we outline some of the characteristics of that context, particularly the rise of “big science” and its effects on patterns of practice (including authorship criteria) in the biomedical sciences and in turn bioethics. We then point to ways in which taking account of this context leads to challenges to some of Resnik and Master’s conclusions, and sketch alternative models that could overcome those difficulties

Repertoires: How to Transform a Project into a Research Community

SubmittedArticleHow effectively communities of scientists come together and co-operate is crucial both to the quality of research outputs and to the extent to which such outputs integrate insights, data and methods from a variety of fields, laboratories and locations around the globe. This essay focuses on the ensemble of material and social conditions that makes it possible for a short-¬‐term collaboration, set up to accomplish a specific task, to give rise to relatively stable communities of researchers. We refer to these distinctive features as repertoires, and investigate their development and implementation across three examples of collaborative research in the life sciences. We conclude that whether a particular project ends up fostering the emergence of a resilient research community is partly determined by the degree of attention and care devoted by researchers to material and social elements beyond the specific research questions under consideration

Model Organisms

A philosophical exploration of the concept of the 'model organism' in contemporary biology. Thinking about model organisms in order to examine how living organisms have been brought into the laboratory and used to gain a better understanding of biology, and to explore the research practices, commitments, and norms underlying this understanding

Impact of environmental factors on stilbene biosynthesis

Stilbenes are a small family of polyphenolic secondary metabolites that can be found in several distantly related plant species. These compounds act as phytoalexins, playing a crucial role in plant defense against phytopathogens, as well as being involved in the adaptation of plants to abiotic environmental factors. Among stilbenes, trans-resveratrol is certainly the most popular and extensively studied for its health properties. In recent years, an increasing number of stilbene compounds were subjected to investigations concerning their bioactivity. This review presents the most updated knowledge of the stilbene biosynthetic pathway, also focusing on the role of several environmental factors in eliciting stilbenes biosynthesis. The effects of ultraviolet radiation, visible light, ultrasonication, mechanical stress, salt stress, drought, temperature, ozone, and biotic stress are reviewed in the context of enhancing stilbene biosynthesis, both in planta and in plant cell and organ cultures. This knowledge may shed some light on stilbene biological roles and represents a useful tool to increase the accumulation of these valuable compounds

Beyond the digital divide: Towards a situated approach to open data

This is the author accepted manuscript. The final version is available from OUP via the DOI in this record.Poor provision of information and communication technologies in low/middle-income countries represents a concern for promoting Open Data. This is often framed as a “digital divide” and addressed through initiatives that increase the availability of information and communication technologies to researchers based in low-resourced environments, as well as the amount of resources freely accessible online, including data themselves. Using empirical data from a qualitative study of lab-based research in Africa we highlight the limitations of such framing and emphasize the range of additional factors necessary to effectively utilize data available online. We adopt the ‘Capabilities Approach’ proposed by Sen to highlight the distinction between simply making resources available, and doing so while fostering researchers’ ability to use them. This provides an alternative orientation that highlights the persistence of deep inequalities within the seemingly egalitarian-inspired Open Data landscape. The extent and manner of future data sharing, we propose, will hinge on the ability to respond to the heterogeneity of research environments.The research informing this article was supported by a grant from the Leverhulme Trust title ‘Beyond the Digital Divide’ (RPG-2013-153). Sabina Leonelli was also funded by the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013)/ ERC grant agreement n° 335925. Ann Kelly’s contribution was also supported by UK Economic Social Research Council Urgency Grants mechanism (ES/M009203/1)

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Probing Hyperbolic and Surface Phonon-Polaritons in 2D materials using Raman Spectroscopy

The hyperbolic dispersion relation of phonon-polaritons (PhPol) provides high-momentum states, highly directional propagation, subdiffractional confinement, large optical density of states, and enhanced light-matter interactions. In this work, we use Raman spectroscopy in the convenient backscattering configuration to probe PhPol in GaSe, a 2D material presenting two hyperbolic regions separated by a \textit{double} reststrahlen band. By varying the incidence angle, dispersion relations are revealed. Raman spectra calculations confirm the observation of one surface and two extraordinary guided polaritons and matches the evolution of PhPol frequency as a function of confinement. Resonant excitation close to the excitonic state singularly exalts the scattering efficiency of PhPol. Raman spectroscopy of PhPol in non-centrosymmetry 2D materials does not require any wavevector matching strategies. Widely available, it may accelerate the development of MIR nanophotonic devices and applications

Geopolymers: A new and smart way for a sustainable development

“Geopolymers” is a general term that describes a wide variety of inorganic and composite materials with limited restrictions on alumina and silica content. In the last decades, they have been also defined as “low-temperature aluminosilicate glasses”, “hydroceramics”, “inorganic polymer concrete” or “alkali bonded ceramics”. Recently, an updated definition has been proposed by the RILEM Technical Committee 224-AAM: “geopolymer materials are essential aluminosilicates activated with alkaline solution, excluding any other alkali-activated materials that should be classified apart” [1]