Mechanisms predisposing penile fracture and long-term outcomes on erectile and voiding functions

Purpose. To determine the mechanisms predisposing penile fracture as well as the rate of long-term penile deformity and erectile and voiding functions. Methods. All fractures were repaired on an emergency basis via subcoronal incision and absorbable suture with simultaneous repair of eventual urethral lesion. Patients’ status before fracture and voiding and erectile functions at long term were assessed by periodic follow-up and phone call. Detailed history included cause, symptoms, and single-question self-report of erectile and voiding functions. Results. Among the 44 suspicious cases, 42 (95.4%) were confirmed, mean age was 34.5 years (range: 18–60), mean follow-up 59.3 months (range 9–155). Half presented the classical triad of audible crack, detumescence, and pain. Heterosexual intercourse was the most common cause (28 patients, 66.7%), followed by penile manipulation (6 patients, 14.3%), and homosexual intercourse (4 patients, 9.5%). “Woman on top” was the most common heterosexual position ( = 14, 50%), followed by “doggy style” (=8, 28.6%). Four patients (9.5%) maintained the cause unclear. Six (14.3%) patients had urethral injury and two (4.8%) had erectile dysfunction, treated by penile prosthesis and PDE-5i. No patient showed urethral fistula, voiding deterioration, penile nodule/curve or pain. Conclusions. “Woman on top” was the potentially riskiest sexual position (50%). Immediate surgical treatment warrants long-term very low morbidity2014sem informaçã

Unraveling Brazilian Indian population prostate good health: clinical, anthropometric and genetic features

To compare dietary, lifestyle, clinical, anthropometric, genetic and prostatic features of Brazilian Indians and non-Indians (Amazon). 315 men, 228 Indians and 89 non-Indians, ≥40 years old were submitted to digital rectal examination, serum prostate specific antigen (PSA), testosterone, TP53 and GSTP1 genotyping, anthropometric, lifestyle, dietary, personal and familial medical history. Prostatic symptoms were evaluated with the International Prostate Symptom Score (IPSS). Macuxis and Yanomamis represented 43.6% and 14.5% of Indians respectively who spontaneously referred no prostate symptoms. Mean IPSS was 7, range 3-19, with only 15% of moderate symptoms (score 8-19); Mean age was 54.7 years, waist circumference 86.6 cm, BMI 23.9 kg/m2. Yanomamis presented both lower BMI (21.4 versus 24.8 and 23.3, p=0,001) and prostate volume than Macuxis and “other ethnic groups” (15 versus 20, p=0.001). Testosterone (414 versus 502 and 512, p=0.207) and PSA (0.48 versus 0.6 and 0.41, p=0.349) were similar with progressive PSA increase with aging. Val/Val correlated with lower PSA (p=0.0361). Indians compared to control population presented: - TP53 super representation of Arg/Arg haplotype, 74.5% versus 42.5%, p<0.0001. -GSTP1 Ile/Ile 35.3% versus 60.9%; Ile/Val 45.9% versus 28.7%; Val/Val 18.8% versus 10.3%; p=0.0003. Observed specific dietary, lifestyle, anthropometric and genetic profile for TP53 and GSTP1 may contribute to Brazilian Indian population prostate good health.41234435

Digital marketing profile of nursing professional ventures published via Instagram / Perfil mercadológico digital de empreendimentos de profissionais de enfermagem divulgados via Instagram

Objective: to identify the digital marketing profile of nursing professionals' ventures disclosed via Instagram. Methods: netnographic study, conducted on Instagram, which is a social network of public access. The sample was composed of 15 profiles of digital entrepreneurs, which were nursing professionals. Data collection was performed between March and May 2022 using hashtags as a search strategy. Results: there was a prevalence of digital books (30,0%), followed by online courses (26,6%). The areas undertaken and the content produced were about wound healing and dressings; general training in the nursing field; law in nursing; entrepreneurship for nurses; ear piercing; obstetric care; general nursing care; and exam preparation. Conclusion: there was a considerable increase in products disseminated via Instagram by nursing professionals, resulting in greater visibility, autonomy, and independence of the professional category.Objetivo: identificar el perfil mercadológico digital de los negocios de profesionales de enfermería divulgados a través de Instagram. Métodos: estudio netnográfico, realizado en el instagram, siendo esta una red social pública. Muestra compuesta por 15 perfiles de empresarios digitales, siendo estos profesionales de enfermería. La recopilación de datos se realizó entre marzo y mayo de 2022 por medio de hashtags. Resultados: predominan los libros digitales (30,0%), seguidos de los cursos en línea (26,6%). Las áreas emprendidas y los contenidos elaborados fueron sobre curación de heridas y vendajes; formación general en el ámbito de la enfermería; derecho en la enfermería; espíritu empresarial para enfermeras; perforación de orejas; cuidados obstétricos; cuidados generales de enfermería; y preparación de exámenes. Conclusión: se ha producido un aumento considerable de los productos difundidos a través de Instagram por profesionales de enfermería, lo que se traduce en una mayor visibilidad, autonomía e independencia de la categoría profesional.Objetivo: identificar o perfil mercadológico digital de empreendimentos de profissionais de enfermagem divulgados via Instagram. Métodos: estudo netnográfico, realizado no Instagram, sendo esta uma rede social de acesso público. A amostra foi composta por 15 perfis de empreendedores digitais, sendo estes profissionais de enfermagem. A coleta de dados foi realizada entre os meses de março e maio de 2022 por meio de hashtags como estratégia de busca. Resultados: houve prevalência de livros digitais (30,0%), seguido de cursos online (26,6%). As áreas empreendidas e os conteúdos produzidos foram sobre cicatrização de feridas e curativos; capacitações gerais do campo da enfermagem; direito na enfermagem; empreendedorismo para enfermeiros; furo de orelha; atendimento obstétrico; atendimentos gerais de enfermagem; e preparatório para concurso. Conclusão: houve um aumento considerável de produtos divulgados via Instagram por profissionais da enfermagem repercutindo em uma maior visibilidade, autonomia e independência da categoria profissional.

Rarity of monodominance in hyperdiverse Amazonian forests.

Tropical forests are known for their high diversity. Yet, forest patches do occur in the tropics where a single tree species is dominant. Such "monodominant" forests are known from all of the main tropical regions. For Amazonia, we sampled the occurrence of monodominance in a massive, basin-wide database of forest-inventory plots from the Amazon Tree Diversity Network (ATDN). Utilizing a simple defining metric of at least half of the trees ≥ 10 cm diameter belonging to one species, we found only a few occurrences of monodominance in Amazonia, and the phenomenon was not significantly linked to previously hypothesized life history traits such wood density, seed mass, ectomycorrhizal associations, or Rhizobium nodulation. In our analysis, coppicing (the formation of sprouts at the base of the tree or on roots) was the only trait significantly linked to monodominance. While at specific locales coppicing or ectomycorrhizal associations may confer a considerable advantage to a tree species and lead to its monodominance, very few species have these traits. Mining of the ATDN dataset suggests that monodominance is quite rare in Amazonia, and may be linked primarily to edaphic factors

Performance of recombinant chimeric proteins in the serological diagnosis of Trypanosoma cruzi infection in dogs.

Background: Dogs are considered sentinels in areas of Trypanosoma cruzi transmission risk to humans. ELISA is generally the method of choice for diagnosing T. cruzi exposure in dogs, but its performance substantially depends on the antigenic matrix employed. In previous studies, our group has developed four chimeric antigens (IBMP-8.1, 8.2, 8.3, and 8.4) and evaluated their potential for diagnosing T. cruzi exposure in humans. For human sera, these chimeric antigens presented superior diagnostic performances as compared to commercial tests available in Brazil, Spain, and Argentina. Therefore, in this study we have evaluated the potential of these antigenic proteins for detection of anti-T. cruzi IgG antibodies in dog sera. Methodology/Principal findings: The IBMP-ELISA assays were optimized by checkerboard titration. Subsequently, the diagnostic potential was validated through analysis of ROC curves and the performance of the tests was determined using double entry tables. Cross-reactivity was also evaluated for babesiosis, ehrlichiosis, dirofilariosis, anaplasmosis, and visceral leishmaniasis. Best performance was shown by IBMP-8.3 and IBMP-8.4, although all four antigens demonstrated a high diagnostic performance with 46 positive and 149 negative samples tested. IBMP-8.3 demonstrated 100% sensitivity, followed by IBMP-8.4 (96.7?100%), IBMP-8.2 (73.3?87.5%), and IBMP-8.1 (50?100%). The highest specificities were achieved with IBMP-8.2 (100%) and IBMP-8.4 (100%), followed by IBMP-8.3 (96.7?97.5%) and IBMP 8.1 (89.1?100%). Conclusions/Significance: The use of chimeric antigenic matrices in immunoassays for anti-T. cruzi IgG antibody detection in sera of infected dogs was shown to be a promising tool for veterinary diagnosis and epidemiological studies. The chimeric antigens used in this work allowed also to overcome the common hurdles related to serodiagnosis of T. cruzi infection, especially regarding variation of efficiency parameters according to different strains and cross-reactivity with other infectious diseases

Measurement of the t(t)over-bar production cross section in the dilepton channel in pp collisions at √s=8 TeV

The top-antitop quark (t (t) over bar) production cross section is measured in proton-proton collisions at root s = 8 TeV with the CMS experiment at the LHC, using a data sample corresponding to an integrated luminosity of 5.3 fb(-1). The measurement is performed by analysing events with a pair of electrons or muons, or one electron and one muon, and at least two jets, one of which is identified as originating from hadronisation of a bottom quark. The measured cross section is 239 +/- 2 (stat.) +/- 11 (syst.) +/- 6 (lum.) pb, for an assumed top-quark mass of 172.5 GeV, in agreement with the prediction of the standard model