Overtopping formula for vertical tiers-headed breakwaters

The semi-empirical methods are useful tools to understand the wave overtopping phenomena, but uncertainty remains on their applicability. It’s necessary to carry out campaign surveys or laboratory tests to support them. In this paper we apply the methods proposed in the European Overtopping Manual (2007) in order to assess the flows over a vertical breakwater, marking the need to calibrate those methodologies to take into account the peculiar geometry of the structural system. This was done by introducing appropriate correction factors. The results show an improved accuracy, among numerical results and physical ones.Postprint (published version

Endotelio e hipertensión arterial

Role of endothelial function in cardiovascular health and its relation with arterial hypertension has been demonstrated. Some studies show that endothelial dysfunction may produce arterial hypertension but other studies find that arterial hypertension per se produces endothelial damage. Due to the fact of various clinical conditions associated to endothelial dysfunction it is of great interest protection of the endothelium.Se ha demostrado el rol de la función endotelial en la salud cardiovascular y su relación con la hipertensión arterial. Ciertos estudios demuestran que la disfunción endotelial es un posible mecanismo que produce hipertensión arterial (HTA), mientras otros demuestran que la HTA per se produce daño endotelial. Se conoce varias condiciones clínicas asociadas a la disfunción endotelial, por lo que es de gran interés la protección del endotelio

DC/DC Converter Parametric Models for System level Simulation

The objective of this work is to propose a whole solution for simulating power systems based on the use of behavioral DC/DC converter models. The proposed model is a generic model whose parameters can be obtained from data sheets (especially useful to model commercial converters) or equivalent tests. The model has configurable features which can be activated or disabled in order to perform optimal simulations or to generate models with different levels of abstraction to be used in a top-down design methodology

Modeling and Simulation Requirements for the Analysis and Design of DC Distributed Power Electronics Systems

The objective of this paper is to establish which are the requirements of the component models in a distributed power system in order to satisfy the necessities of the system architect. Based on the information that will help the designer to make the right decision for its architecture and the selection of their components, different levels of modeling will be required for each simulation. The paper also shows the implication of the modeling approach on the requirements for the simulator and the description language

Robustness Analysis of DC Distributed Power Systems by Means of Behavioral DC-DC Converter Models

The aim of this paper is to determine the model requirements for dc-dc converters in order to analyze and evaluate the performance of different architectures of DC distributed power systems and to assure that all the specifications are met under all parameter variations. Based on these requirements a parametric model for the dc-dc converters is presented that can be identified as a function of the information given by the manufacturers in their datasheets. In this way, it is possible to make sensitivity and worst case analysis that can help the designer to evaluate the robustness of their architectures

Top-down methodology employing hardware description languages (HDLs) for designing digital control in power converters

This paper presents a research line oriented to develop methodologies that takes advantage of hardware description languages in order to simplify the design of power converters that employ digital control techniques. The methodology focuses on setting the adequate communications among subsystems in order to simplify the change of the levels of abstraction of the subsystem’s models (from the conceptual level to the actual electric + synthesizable code). Changing the level of abstraction in the design process pretends: first to provide useful models at early designing steps; second, to optimize the simulation of the system, and at same time optimize the verification step

A Parametrization Tool for Power Electronics Design at System Level

This paper describes a parameterization software used for the generation of behavioral models of power converters. This tool eases the capture and generation of fast and accurate models based on the information provided by manufacturers and measures. The models incorporate many behavioral features and can be used at different levels in the analysis, design and verification of complete power distribution systems like aircraft and automotive power systems. Simulations of common tests of power systems are presented to show the functionality of the models

Aging, cancer, and cancer vaccines

World population has experienced continuous growth since 1400 A.D. Current projections show a continued increase - but a steady decline in the population growth rate - with the number expected to reach between 8 and 10.5 billion people within 40 years. The elderly population is rapidly rising: in 1950 there were 205 million people aged 60 or older, while in 2000 there were 606 million. By 2050, the global population aged 60 or over is projected to expand by more than three times, reaching nearly 2 billion people [1]. Most cancers are age-related diseases: in the US, 50% of all malignancies occur in people aged 65-95. 60% of all cancers are expected to be diagnosed in elderly patients by 2020 [2]. Further, cancer-related mortality increases with age: 70% of all malignancy-related deaths are registered in people aged 65 years or older [3]. Here we introduce the microscopic aspects of aging, the pro-inflammatory phenotype of the elderly, and the changes related to immunosenescence. Then we deal with cancer disease and its development, the difficulty of treatment administration in the geriatric population, and the importance of a comprehensive geriatric assessment. Finally, we aim to analyze the complex interactions of aging with cancer and cancer vaccinology, and the importance of this last approach as a complementary therapy to different levels of prevention and treatment. Cancer vaccines, in fact, should at present be recommended in association to a stronger cancer prevention and conventional therapies (surgery, chemotherapy, radiation therapy), both for curative and palliative intent, in order to reduce morbidity and mortality associated to cancer progression

Fast architecture generation and evaluation techniques for the design of large power systems

This paper presents a methodology used to simplify the design of power supply systems based on high level of abstraction simulation models. This approach allows the designer to make decisions concerning the power system architecture and its components. This paper is focused on the techniques to identify topology candidates that can be built with available voltage regulator technologies and find the solution with best trade-off among energy efficiency, size and cost. In order to solve the problem when the number of possible options is very large, metaheuristic algorithms are used

Power Conversion Modeling Methodology Based on Building Block Models

Power systems modeling tools used to analyze static and dynamic characteristics usually rely on detailed and complex models, thus taking a long simulation time. Due to the acceleration of time to market of today's computing platforms, it is required to arrive at feasible solution options in a short amount of time to meet cost and time targets. Specifically, the areas of power conversion and power management traditionally rely on experimental verification and are lacking in computer design methodologies. In this paper, a modeling methodology based on fundamental building block models for power delivery systems is presented to address the aspects of energy efficiency optimization, area occupied by the power delivery solution and the cost associated with power conversion