The land of deformation south of 68^{68}Ni

We study the development of collectivity in the neutron-rich nuclei around $N=40$, where experimental and theoretical evidences suggest a rapid shape change from the spherical to the rotational regime, in analogy to what happens at the {\it island of inversion} surrounding $^{31}$Na. Theoretical calculations are performed within the interacting shell model framework in a large valence space, based on a $^{48}$Ca core which encompasses the full $pf$ shell for the protons and the $0f_{5/2}$, $1p_{3/2}$, $1p_{1/2}$, $0g_{9/2}$ and $1d_{5/2}$ orbits for the neutrons. The effective interaction is based on a G-matrix obtained from a realistic nucleon-nucleon potential whose monopole part is corrected empirically to produce effective single particle energies compatible with the experimental data. We find a good agreement between the theoretical results and the available experimental data. We predict the onset of deformation at different neutron numbers for the various isotopic chains. The maximum collectivity occurs in the chromium isotopes, where the large deformation regime starts already at $N=38$. The shell evolution responsible for the observed shape changes is discussed in detail, in parallel to the situation in the $N=20$ region

Neutron Skins and Halo Orbits in the sd and pf Shells

open3siThe strong dependence of Coulomb energies on nuclear radii makes it possible to extract the latter from calculations of the former. The resulting estimates of neutron skins indicate that two mechanisms are involved. The first one --isovector monopole polarizability—amounts to noting that when a particle is added to a system it drives the radii of neutrons and protons in different directions, tending to equalize the radii of both fluids independently of the neutron excess. This mechanism is well understood and the Duflo- Zuker (small) neutron skin values derived 14 years ago are consistent with recent measures and estimates. The alternative mechanism involves halo orbits whose huge sizes tend to make the neutron skins larger and have a subtle influence on the radial behavior of sd and f shell nuclei. In particular, they account for the sudden rise in the isotope shifts of nuclei beyond N=28 and the near constancy of radii in the A=40–56 region. This mechanism, detected here for the first time, is not well understood and may well go beyond the Efimov physics usually associated with halo orbits.openBonnard, JEREMY CHRISTIAN FREDERIC; Lenzi, SILVIA MONICA; Zuker, A. P.Bonnard, JEREMY CHRISTIAN FREDERIC; Lenzi, SILVIA MONICA; Zuker, A. P

Isospin-breaking interactions studied through mirror energy differences

Background: Information on charge-dependent (i.e., isospin-non-conserving) interactions is extracted from excited states of mirror nuclei. Purpose: Specifically, the purpose of the study is to extract effective isovector (Vpp 12Vnn) interactions which, in general, can either be of Coulomb or nuclear origin. Methods: A comprehensive shell-model description of isospin-breaking effects is used to fit data on mirror energy differences in the A = 42\u201354 region. The angular-momentum dependence of isospin-breaking interactions was determined from a systematic study of mirror energy differences. Results: The results reveal a significant isovector term, with a very strong spin dependence, beyond that expected of a two-body Coulomb interaction. Conclusions: The isospin-breaking terms that are extracted have a J dependence that is not consistent with the known CSB properties of the bare nucleon-nucleon interaction

Aion, Eros e Hades nei frammenti caldaici

The essay deals with some aspects of the knotty question concerning the presence of Aion, Eros and Hades in the variegated universe of the Chaldean Oracles, traditionally attributed to a collaboration between two “Hellenized Magi” of the second c. AD: Julian “the Chaldean” and his son Julian “the Theurgist” (even if the theurgical expertise of the elder Julian, the repository of a more ancient Chaldean tradition, might not involve a direct eastern origin but only his knowledge of “Chaldean” sciences such as astrology and divination”). Aion, who is examined here in terms of his relationship with Chronos, as a more or less autonomous divinity, is mentioned only in the context of some fragments, but his name never appears in the oracular verses. Eros (beloging also to the triad of fr. 46, along with “Faith” and “Truth”) stands for an independent cosmological principle whose task is to preserve the universe and the armony of the cosmos. The Chaldean Oracles never make any explicit mention of Hades, who anyway is cited by the Byzantine scholar Psellos as an autonomous divinity of the Chaldeans

Disability, Physical Inactivity, and Impaired Health-Related Quality of Life Are Not Different in Metabolically Healthy vs. Unhealthy Obese Subjects

BACKGROUND: Obesity represents a major health hazard, affecting morbidity, psychological status, physical functionality, quality of life, and mortality. The aim of the present study was to explore the differences between metabolically healthy (MHO) and metabolically unhealthy (MUO) obese subjects with regard to physical activity, disability, and health-related quality of life (HR-QoL). METHODS: All subjects underwent a multidimensional evaluation, encompassing the assessment of body composition, metabolic biomarkers and inflammation, physical activity level (IPAQ questionnaire), disability (TSD-OC test), and HR-QoL (SF-36 questionnaire). MHO and MUO were defined based on the absence or the presence of the metabolic syndrome, respectively. RESULTS: 253 subjects were included (54 men and 199 women; age: 51.7 ± 12.8 vs. 50.3 ± 11.7 years, p = 0.46; BMI: 38.1 ± 5.7 vs. 38.9 ± 6.7 kg/m², p = 0.37). No significant difference was observed in body composition. There was no difference between MHO and MUO considering inflammation (hs-CRP: 6517.1 ± 11,409.9 vs. 5294.1 ± 5612.2 g/L; p = 0.37), physical inactivity (IPAQ score below 3000 METs-min/week in 77.6% of MHO vs. 80% of MUO subjects; p = 0.36), obesity-related disability (TSD-OC score > 33%, indicating a high level of obesity-related disability, in 20.2% of MHO vs. 26.5% of MUO subjects; p = 0.28), and the HR-QoL (SF-36 total score: 60 ± 20.8 vs. 62.8 ± 18.2, p = 0.27). DISCUSSION AND CONCLUSION:The metabolic comorbidity and the impairment of functional ability and psycho-social functioning may have a different timing in the natural history of obesity. Alterations in the physical activity level and mobility disabilities may precede the onset of metabolic abnormalities. (Trial registration 2369 prot 166/12-registered 23 February 2012; Amendment 223/14-registered 13 February 2014)

Assessment of trabecular bone score (TBS) in overweight/obese men: effect of metabolic and anthropometric factors

The "trabecular bone score" (TBS) indirectly explores bone quality, independently of bone mineral density (BMD). We investigated the effects of anthropometric and metabolic parameters on TBS in 87 overweight/obese men. We assessed BMD and TBS by DXA, and some parameters of glucose metabolism, sex-and calciotropic hormone levels. Regression models were adjusted for either age and BMI, or age and waist circumference, or age and waist/hip ratio, also considering BMI >35 (y/n) and metabolic syndrome (MS) (y/n). Correlations between TBS and parameters studied were higher when correcting for waist circumference, although not significant in subjects with BMI >35. The analysis of covariance showed that the same model always had a higher adjusted r-square index. BMD at lumbar spine and total hip, fasting glucose, bioavailable testosterone, and sex hormone-binding globulin are the only covariates having a significant effect (p 35 on TBS values or significant interaction terms between each covariate and either BMI >35 or the presence of MS. Obesity negatively affected TBS, despite unchanged BMD. Alterations of glucose homeostasis and sex hormone levels seem to influence this relationship, while calciotropic hormones have no role. The effect of waist circumference on TBS is more pronounced than that of BMI

An Exploratory Study on the Influence of Psychopathological Risk and Impulsivity on BMI and Perceived Quality of Life in Obese Patients

The present study aimed to assess the psychological profiles of adult male and female obese patients, as well as to verify the possible influence of their psychopathological risk and impulsivity on their body mass index (BMI) and perceived quality of life. A total of 64 obese subjects accessing a center for care of their obesity were assessed through anthropometric and psychometric measurements. All anthropometric measures in men were higher than in women, while in turn, women showed higher psychopathological symptoms. Furthermore, the symptoms of somatization and psychoticism were predictors for a higher BMI in men, but there was no effect of psychopathological symptoms on the perceived quality of life (QoL) of male subjects. Moreover, in women, somatization and attentional impulsivity were predictors for a higher BMI, whereas no correlation was found between their psychopathological risk and perceived QoL. The results of regression analysis underlined that somatization is a “core” psychopathological symptom in obese subjects regardless of their sex, which is a potential predictor for a higher BMI. The psychological difficulties of the subjects had no effect on their perceived QoL, suggesting that they find it difficult to reflect on the impact that obesity has on their life

Tadalafil improves lean mass and endothelial function in nonobese men with mild ED/LUTS: in vivo and in vitro characterization

PURPOSE: Phosphodiesterase type-5 inhibitor administration in diabetic men with erectile dysfunction (ED) is associated with reduced waist circumference. We evaluated potential effects of daily tadalafil administration on body composition and investigated its possible mechanism(s) of action in C2C12 skeletal muscle cells in vitro. METHODS: Forty-three men on stable caloric intake (mean age 48.5 ± 7; BMI 25.5 ± 0.9 kg/m2) complaining mild ED and/or low urinary tract symptoms (LUTS) were randomly assigned to receive tadalafil (TAD) 5 mg/daily (once-a-day=OAD-TAD; n = 23) or 20 mg on-demand (on-demand=OD-TAD; n = 20) for 2 months. Primary outcomes were variations of body composition measured by Dual-energy X-ray absorptiometry; secondary outcomes were ED/LUTS questionnaire scores along with hormone (testosterone, estradiol, insulin) and endothelial function (Endopat2000) variations. RESULTS: OAD-TAD increased abdominal lean mass (p < 0.01) that returned to baseline after 2 months withdrawal. LUTS scores improved (p<0.01) in OD-TAD while ED scores improved (p < 0.01) in both groups. We found significant improvements in endothelial function (p < 0.05) that directly correlated with serum insulin (p < 0.01; r = 0.3641) and inversely correlated with estradiol levels (p < 0.01; r = 0.3655) even when corrected for potential confounders. Exposure of C2C12 cells upon increasing tadalafil concentrations (10-7 to 10-6 M) increased total androgen receptor mRNA and protein expression as well as myogenin protein expression after 24 and 72 h (2.8 ± 0.4-fold and 1.4 ± 0.02-fold vs. control, respectively, p < 0.05). CONCLUSIONS: Daily tadalafil improved lean mass content in non-obese men probably via enhanced insulin secretion, estradiol reduction, and improvement of endothelial function in vivo. The in vitro increased myogenin and androgen receptor protein expression in skeletal muscle cells suggests a translational action of phosphodiesterase type-5 on this receptor

Isospin symmetry violation in mirror E1 transitions: Coherent contributions from the giant isovector monopole resonance in the 67As-67Se doublet

The assumption of an exact isospin symmetry would imply equal strengths for mirror E1 transitions (at least, in the long-wavelength limit). Actually, large violations of this symmetry rule have been indicated by a number of experimental results, the last of which is the 67As-67Se doublet investigated at GAMMASPHERE. Here, we examine in detail various possible origins of the observed asymmetry. The coherent effect of Coulomb-induced mixing with the high-lying giant isovector monopole resonance is proposed as the most probable process to produce a large asymmetry in the E1 transitions, with comparatively small effect on the other properties of the parent and daughter levels. © 2012 American Physical Society.Financial support from the Spanish Ministry of Economy and Competitiveness, via the Project Consolider Ingenio (CPAN) (CSD2007-42).Peer Reviewe

A prospective study on contrast-enhanced magnetic resonance imaging of testicular lesions: distinctive features of Leydig cell tumours

OBJECTIVES: Up to 20 % of incidentally found testicular lesions are benign Leydig cell tumours (LCTs). This study evaluates the role of contrast-enhanced magnetic resonance imaging (MRI) in the identification of LCTs in a large prospective cohort study. MATERIALS AND METHODS: We enrolled 44 consecutive patients with at least one solid non-palpable testicular lesion who underwent scrotal MRI. Margins of the lesions, signal intensity and pattern of wash-in and wash-out were analysed by two radiologists. The frequency distribution of malignant and benign MRI features in the different groups was compared by using the chi-squared or Fisher's exact test. Sensitivity, specificity, positive and negative predictive value, and diagnostic accuracy were calculated. RESULTS: The sensitivity of scrotal MRI to diagnose LCTs was 89.47 % with 95.65 % specificity; sensitivity for malignant lesions was 95.65 % with 80.95 % specificity. A markedly hypointense signal on T2-WI, rapid and marked wash-in followed by a prolonged washout were distinctive features significantly associated with LCTs. Malignant lesions were significantly associated with blurred margins, weak hypointense signal on T2-WI ,and weak and progressive wash-in. The overall diagnostic accuracy was 93 %. CONCLUSIONS: LCTs have distinctive contrast-enhanced MRI features that allow the differential diagnosis of incidental testicular lesions. KEY POINTS: • MRI is able to characterize testicular lesions suggesting a specific diagnosis. • Rapid and marked wash-in is a common feature of Leydig cell tumours. • Markedly hypointense T2-WI signal is significantly correlated with benign lesions. • Blurred margins and weak hypointense T2-WI signal are correlated with malignant tumours. • Weak and progressive wash-in features are present in 85 % of seminomatous lesions